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rSAMs-NANO SIGNED

Nanoparticles with switchable shells for virus sensing and inhibition

Total Cost €

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EC-Contrib. €

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Partnership

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 rSAMs-NANO project word cloud

Explore the words cloud of the rSAMs-NANO project. It provides you a very rough idea of what is the project "rSAMs-NANO" about.

nanoparticle    thiol    strategy    ligand    saccharide    efficiency    stability    enhanced    diagnostics    benchmark    multivalent    prevents    biointerfacial    multiple    affinities    sams    biointerfaces    self    decorated    free    group    blocking    particle    composition    stages    switchable    interactions    particles    antiviral    animal    sensors    nanoparticles    virus    ebola    capability    shell    architectures    pathogens    prepare    inhibit    shells    validated    selectivity    assays    surface    assemblies    affinity    inhibition    dendritic    relying    monolayers    tunable    drug    contrast    reversible    binding    nature    ultrasensitive    human    assembled    series    entry    receptor    weak    dynamic    versions    strains    receptors    terminated    ligands    rsams    subtyping    featuring    layer    fixed    ph    head    covalently    antibody    biological    amidines    exploring    respect    lipid    density    explored    responsiveness    relies    detection    situ    nanoplasmonic    artificial    select    multivalency    interacting    simultaneously    viruses    generation    model    inhibitors    compromises    rapid    saccharides    sensing    first    drugs    influenza    infection    bilayers   

Project "rSAMs-NANO" data sheet

The following table provides information about the project.

Coordinator
MALMO UNIVERSITET 

Organization address
address: NORDENSKIOLDSGATAN 1
city: MALMOE
postcode: 205 06
website: www.mah.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country Sweden [SE]
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2018
 Duration (year-month-day) from 2018-09-03   to  2020-09-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MALMO UNIVERSITET SE (MALMOE) coordinator 185˙857.00

Map

 Project objective

This proposal concerns Reversible Self-assembled Monolayers (rSAMs) as dynamic nanoparticle shells for multivalent interactions at biointerfaces. Current drug design and diagnostics are exploring the multivalency concept, i.e. binding of biological targets via multiple weak interactions. In contrast to classical drug design relying on high-affinity inhibitors, this relies on dendritic architectures featuring a high density of ligands, e.g. saccharides, capable of simultaneously interacting with biointerfacial receptors. This strategy can be used to inhibit the virus entry by blocking the receptor at the early stages of infection and the concept is being explored as antiviral drugs and in virus sensing. However, in current systems ligands are covalently fixed on the particle surface. This prevents control over the ligand distribution and composition which compromises selectivity and affinity of the interactions. rSAMs are pH-switchable versions of thiol-SAMs. They are tunable with respect to the nature of the head group and layer order and stability while featuring pH responsiveness and the dynamic nature of non-covalently build assemblies e.g. lipid bilayers. Ligand decorated rSAMs therefore feature strongly enhanced affinities for multivalent targets. The main aims of this proposal are: 1) to investigate the use of rSAMs as dynamic nanoparticle shells for multivalent inhibition of viruses and 2) to assess such systems as nanoplasmonic sensors for antibody-free ultrasensitive, robust and rapid in situ virus detection. Under 1) we will select model pathogens, e.g. Ebola and prepare a series of saccharide terminated amidines for the first generation dynamic shell nanoparticles.Their efficiency will be assessed in infection assays using artificial virus particles Under 2) we will develop influenza virus sensors with subtyping capability within human and animal virus strains. The sensors will be validated with respect to benchmark assays.

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