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rSAMs-NANO SIGNED

Nanoparticles with switchable shells for virus sensing and inhibition

Total Cost €

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EC-Contrib. €

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Partnership

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 rSAMs-NANO project word cloud

Explore the words cloud of the rSAMs-NANO project. It provides you a very rough idea of what is the project "rSAMs-NANO" about.

viruses    density    antibody    antiviral    head    covalently    detection    artificial    biological    validated    nanoplasmonic    assemblies    ligands    sensors    surface    efficiency    multivalency    animal    architectures    ultrasensitive    relying    biointerfacial    pathogens    assays    strategy    prepare    responsiveness    generation    particles    saccharide    diagnostics    situ    stability    strains    nature    affinity    multiple    drugs    featuring    bilayers    fixed    ligand    group    inhibition    enhanced    shells    versions    prevents    simultaneously    layer    drug    switchable    selectivity    receptors    amidines    interactions    subtyping    rsams    dendritic    capability    sensing    series    assembled    ebola    saccharides    multivalent    benchmark    binding    exploring    inhibit    stages    affinities    model    lipid    human    influenza    free    virus    compromises    reversible    tunable    explored    nanoparticles    respect    dynamic    sams    biointerfaces    rapid    shell    contrast    thiol    select    interacting    terminated    receptor    relies    ph    blocking    inhibitors    composition    self    weak    monolayers    infection    first    entry    decorated    particle    nanoparticle   

Project "rSAMs-NANO" data sheet

The following table provides information about the project.

Coordinator
MALMO UNIVERSITET 

Organization address
address: NORDENSKIOLDSGATAN 1
city: MALMOE
postcode: 205 06
website: www.mah.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2018
 Duration (year-month-day) from 2018-09-03   to  2020-09-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MALMO UNIVERSITET SE (MALMOE) coordinator 185˙857.00

Map

 Project objective

This proposal concerns Reversible Self-assembled Monolayers (rSAMs) as dynamic nanoparticle shells for multivalent interactions at biointerfaces. Current drug design and diagnostics are exploring the multivalency concept, i.e. binding of biological targets via multiple weak interactions. In contrast to classical drug design relying on high-affinity inhibitors, this relies on dendritic architectures featuring a high density of ligands, e.g. saccharides, capable of simultaneously interacting with biointerfacial receptors. This strategy can be used to inhibit the virus entry by blocking the receptor at the early stages of infection and the concept is being explored as antiviral drugs and in virus sensing. However, in current systems ligands are covalently fixed on the particle surface. This prevents control over the ligand distribution and composition which compromises selectivity and affinity of the interactions. rSAMs are pH-switchable versions of thiol-SAMs. They are tunable with respect to the nature of the head group and layer order and stability while featuring pH responsiveness and the dynamic nature of non-covalently build assemblies e.g. lipid bilayers. Ligand decorated rSAMs therefore feature strongly enhanced affinities for multivalent targets. The main aims of this proposal are: 1) to investigate the use of rSAMs as dynamic nanoparticle shells for multivalent inhibition of viruses and 2) to assess such systems as nanoplasmonic sensors for antibody-free ultrasensitive, robust and rapid in situ virus detection. Under 1) we will select model pathogens, e.g. Ebola and prepare a series of saccharide terminated amidines for the first generation dynamic shell nanoparticles.Their efficiency will be assessed in infection assays using artificial virus particles Under 2) we will develop influenza virus sensors with subtyping capability within human and animal virus strains. The sensors will be validated with respect to benchmark assays.

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