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rSAMs-NANO SIGNED

Nanoparticles with switchable shells for virus sensing and inhibition

Total Cost €

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EC-Contrib. €

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Partnership

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 rSAMs-NANO project word cloud

Explore the words cloud of the rSAMs-NANO project. It provides you a very rough idea of what is the project "rSAMs-NANO" about.

antibody    relying    strains    decorated    versions    select    assembled    explored    situ    inhibit    amidines    series    rapid    particle    interacting    stages    shell    saccharides    biointerfacial    dynamic    inhibition    capability    blocking    human    detection    nature    ultrasensitive    interactions    bilayers    multiple    respect    group    self    multivalency    covalently    ligands    thiol    contrast    multivalent    free    strategy    terminated    first    layer    surface    dendritic    model    prepare    benchmark    monolayers    ebola    stability    shells    composition    generation    diagnostics    assays    responsiveness    enhanced    particles    compromises    drug    virus    density    switchable    sams    receptor    pathogens    drugs    assemblies    affinity    weak    nanoplasmonic    rsams    prevents    nanoparticles    inhibitors    sensors    animal    ph    artificial    reversible    fixed    head    viruses    influenza    ligand    sensing    simultaneously    architectures    validated    relies    biointerfaces    antiviral    efficiency    exploring    lipid    nanoparticle    binding    affinities    selectivity    biological    infection    receptors    saccharide    entry    tunable    subtyping    featuring   

Project "rSAMs-NANO" data sheet

The following table provides information about the project.

Coordinator
MALMO UNIVERSITET 

Organization address
address: NORDENSKIOLDSGATAN 1
city: MALMOE
postcode: 205 06
website: www.mah.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2018
 Duration (year-month-day) from 2018-09-03   to  2020-09-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MALMO UNIVERSITET SE (MALMOE) coordinator 185˙857.00

Map

 Project objective

This proposal concerns Reversible Self-assembled Monolayers (rSAMs) as dynamic nanoparticle shells for multivalent interactions at biointerfaces. Current drug design and diagnostics are exploring the multivalency concept, i.e. binding of biological targets via multiple weak interactions. In contrast to classical drug design relying on high-affinity inhibitors, this relies on dendritic architectures featuring a high density of ligands, e.g. saccharides, capable of simultaneously interacting with biointerfacial receptors. This strategy can be used to inhibit the virus entry by blocking the receptor at the early stages of infection and the concept is being explored as antiviral drugs and in virus sensing. However, in current systems ligands are covalently fixed on the particle surface. This prevents control over the ligand distribution and composition which compromises selectivity and affinity of the interactions. rSAMs are pH-switchable versions of thiol-SAMs. They are tunable with respect to the nature of the head group and layer order and stability while featuring pH responsiveness and the dynamic nature of non-covalently build assemblies e.g. lipid bilayers. Ligand decorated rSAMs therefore feature strongly enhanced affinities for multivalent targets. The main aims of this proposal are: 1) to investigate the use of rSAMs as dynamic nanoparticle shells for multivalent inhibition of viruses and 2) to assess such systems as nanoplasmonic sensors for antibody-free ultrasensitive, robust and rapid in situ virus detection. Under 1) we will select model pathogens, e.g. Ebola and prepare a series of saccharide terminated amidines for the first generation dynamic shell nanoparticles.Their efficiency will be assessed in infection assays using artificial virus particles Under 2) we will develop influenza virus sensors with subtyping capability within human and animal virus strains. The sensors will be validated with respect to benchmark assays.

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