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rSAMs-NANO SIGNED

Nanoparticles with switchable shells for virus sensing and inhibition

Total Cost €

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EC-Contrib. €

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Partnership

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 rSAMs-NANO project word cloud

Explore the words cloud of the rSAMs-NANO project. It provides you a very rough idea of what is the project "rSAMs-NANO" about.

featuring    architectures    self    exploring    thiol    versions    dendritic    blocking    layer    infection    group    model    antibody    multiple    drug    selectivity    assays    amidines    multivalency    first    benchmark    entry    prepare    strategy    shells    assembled    dynamic    responsiveness    binding    respect    sams    human    density    inhibition    head    validated    inhibitors    saccharides    ebola    rapid    stages    saccharide    generation    biointerfaces    inhibit    pathogens    prevents    detection    composition    series    assemblies    explored    interacting    ligands    contrast    antiviral    biointerfacial    drugs    animal    nature    viruses    relies    nanoparticle    diagnostics    virus    monolayers    select    ultrasensitive    receptors    sensors    particle    terminated    ph    affinities    covalently    free    rsams    sensing    simultaneously    strains    nanoplasmonic    nanoparticles    fixed    situ    decorated    enhanced    weak    influenza    relying    reversible    compromises    shell    particles    receptor    stability    biological    artificial    bilayers    subtyping    lipid    efficiency    interactions    tunable    surface    affinity    switchable    ligand    multivalent    capability   

Project "rSAMs-NANO" data sheet

The following table provides information about the project.

Coordinator
MALMO UNIVERSITET 

Organization address
address: NORDENSKIOLDSGATAN 1
city: MALMOE
postcode: 205 06
website: www.mah.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2018
 Duration (year-month-day) from 2018-09-03   to  2020-09-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MALMO UNIVERSITET SE (MALMOE) coordinator 185˙857.00

Map

 Project objective

This proposal concerns Reversible Self-assembled Monolayers (rSAMs) as dynamic nanoparticle shells for multivalent interactions at biointerfaces. Current drug design and diagnostics are exploring the multivalency concept, i.e. binding of biological targets via multiple weak interactions. In contrast to classical drug design relying on high-affinity inhibitors, this relies on dendritic architectures featuring a high density of ligands, e.g. saccharides, capable of simultaneously interacting with biointerfacial receptors. This strategy can be used to inhibit the virus entry by blocking the receptor at the early stages of infection and the concept is being explored as antiviral drugs and in virus sensing. However, in current systems ligands are covalently fixed on the particle surface. This prevents control over the ligand distribution and composition which compromises selectivity and affinity of the interactions. rSAMs are pH-switchable versions of thiol-SAMs. They are tunable with respect to the nature of the head group and layer order and stability while featuring pH responsiveness and the dynamic nature of non-covalently build assemblies e.g. lipid bilayers. Ligand decorated rSAMs therefore feature strongly enhanced affinities for multivalent targets. The main aims of this proposal are: 1) to investigate the use of rSAMs as dynamic nanoparticle shells for multivalent inhibition of viruses and 2) to assess such systems as nanoplasmonic sensors for antibody-free ultrasensitive, robust and rapid in situ virus detection. Under 1) we will select model pathogens, e.g. Ebola and prepare a series of saccharide terminated amidines for the first generation dynamic shell nanoparticles.Their efficiency will be assessed in infection assays using artificial virus particles Under 2) we will develop influenza virus sensors with subtyping capability within human and animal virus strains. The sensors will be validated with respect to benchmark assays.

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