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Multiscale Integrative Approach for Corneal Biomechanics to Assess Corneal Crosslinking

Total Cost €


EC-Contrib. €






 MIMetiCO project word cloud

Explore the words cloud of the MIMetiCO project. It provides you a very rough idea of what is the project "MIMetiCO" about.

250    framework    nano    protrusion    pressure    impaired    depending    biochemical    mechanisms    tissue    rely    macroscopic    becomes    combine    microscopy    collagen    noninvasive    economic    plan    pathologies    keratoconus    benefit    surgery    intermolecular    morphological    bounding    inflation    crosslinking    phenomena    stresses    stiffening    usually    orientation    confocal    vision    biomechanics    imbalanced    completely    million    breaking    cornea    intraocular    balance    experiments    visually    interventions    technologies    mimetico    postsurgical    stiffness    corneal    people    computational    models    structural    amount    micro    halting    model    molecules    chemical    density    silico    refractive    outcomes    treatment    scales    inducing    tests    clinical    ophthalmology    ectasias    modeling    simulate    treatments    calibrate    fibrils    approximately    cxl    crosslinks    virtual    unexpected    worldwide    multiscale    strategies    social    characterization    generation    ground    uniformly    mainly    first    internal    mechanical   

Project "MIMetiCO" data sheet

The following table provides information about the project.


Organization address
city: BERN
postcode: 3012

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 175˙419.00


 Project objective

Approximately 250 million people worldwide are visually impaired, and this has great economic and social impact. One of the pathologies of vision loss is keratoconus, in which the mechanical balance of the cornea depending on intraocular pressure and internal stresses in corneal tissue becomes imbalanced, which can result in a corneal protrusion.

Corneal crosslinking (CXL) is a clinical treatment that increases the overall mechanical stiffness of the cornea by inducing chemical bounding between collagen molecules. CXL is the present of halting corneal ectasias, and the future of noninvasive refractive surgery. However, its micro/nano-mechanisms are not completely understood. Moreover, CXL is usually applied uniformly in corneal treatments, which can result in over-stiffening and unexpected postsurgical outcomes.

Ophthalmology can benefit from in silico modeling to plan and improve such interventions. However, current computational models are mainly macroscopic and cannot simulate complex phenomena involved in CXL. Multiscale computational models could improve clinical strategies by including information at different scales.

MIMetiCO’s goal is to combine experiments and modelling at different scales to provide a multiscale characterization of corneal biomechanics before and after CXL. This characterization will rely on both ground-breaking and well-established technologies that include confocal microscopy, biochemical assessment, and mechanical inflation tests to determine morphological (orientation and density of fibrils), biochemical (amount of intermolecular crosslinks), and mechanical features of the cornea.

MIMetiCO will use this information to calibrate the first in silico model of the cornea using a multiscale structural approach to build a virtual framework to simulate potential CXL treatments.

MIMetiCO is the next step in ophthalmology, which has the potential to bring into being a new generation of clinical assessment.

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The information about "MIMETICO" are provided by the European Opendata Portal: CORDIS opendata.

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