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Multiscale Integrative Approach for Corneal Biomechanics to Assess Corneal Crosslinking

Total Cost €


EC-Contrib. €






 MIMetiCO project word cloud

Explore the words cloud of the MIMetiCO project. It provides you a very rough idea of what is the project "MIMetiCO" about.

phenomena    stresses    completely    bounding    intraocular    plan    intermolecular    ophthalmology    stiffness    structural    depending    worldwide    orientation    stiffening    silico    mechanical    confocal    mimetico    keratoconus    mainly    biomechanics    clinical    people    treatments    usually    postsurgical    social    molecules    protrusion    characterization    interventions    million    scales    virtual    nano    strategies    simulate    breaking    combine    technologies    visually    fibrils    economic    collagen    imbalanced    cxl    treatment    calibrate    impaired    ground    noninvasive    framework    ectasias    micro    mechanisms    halting    balance    pressure    approximately    amount    unexpected    multiscale    microscopy    250    corneal    morphological    benefit    tests    inducing    tissue    crosslinking    crosslinks    inflation    chemical    cornea    internal    generation    density    becomes    outcomes    uniformly    first    experiments    models    surgery    refractive    macroscopic    biochemical    model    modeling    rely    vision    computational    pathologies   

Project "MIMetiCO" data sheet

The following table provides information about the project.


Organization address
city: BERN
postcode: 3012

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 175˙419.00


 Project objective

Approximately 250 million people worldwide are visually impaired, and this has great economic and social impact. One of the pathologies of vision loss is keratoconus, in which the mechanical balance of the cornea depending on intraocular pressure and internal stresses in corneal tissue becomes imbalanced, which can result in a corneal protrusion.

Corneal crosslinking (CXL) is a clinical treatment that increases the overall mechanical stiffness of the cornea by inducing chemical bounding between collagen molecules. CXL is the present of halting corneal ectasias, and the future of noninvasive refractive surgery. However, its micro/nano-mechanisms are not completely understood. Moreover, CXL is usually applied uniformly in corneal treatments, which can result in over-stiffening and unexpected postsurgical outcomes.

Ophthalmology can benefit from in silico modeling to plan and improve such interventions. However, current computational models are mainly macroscopic and cannot simulate complex phenomena involved in CXL. Multiscale computational models could improve clinical strategies by including information at different scales.

MIMetiCO’s goal is to combine experiments and modelling at different scales to provide a multiscale characterization of corneal biomechanics before and after CXL. This characterization will rely on both ground-breaking and well-established technologies that include confocal microscopy, biochemical assessment, and mechanical inflation tests to determine morphological (orientation and density of fibrils), biochemical (amount of intermolecular crosslinks), and mechanical features of the cornea.

MIMetiCO will use this information to calibrate the first in silico model of the cornea using a multiscale structural approach to build a virtual framework to simulate potential CXL treatments.

MIMetiCO is the next step in ophthalmology, which has the potential to bring into being a new generation of clinical assessment.

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The information about "MIMETICO" are provided by the European Opendata Portal: CORDIS opendata.

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