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MechanoIMM SIGNED

Mechanical Immunoengineering for Enhanced T-cell Immunotherapy

Total Cost €

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EC-Contrib. €

0

Partnership

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 MechanoIMM project word cloud

Explore the words cloud of the MechanoIMM project. It provides you a very rough idea of what is the project "MechanoIMM" about.

overcome    cytokine    solid    attacking    stiffness    dramatic    mechanical    largely    mechano    drugs    put    nanoparticle    reagents    prevent    augment    biochemical    adoptive    fight    minimize    biomechanical    first    cues    biophysical    elicited    tumour    patient    underappreciated    infuses    reaching    cancer    force    immunity    immunoengineering    generating    toxicity    immunomodulation    power    standard    modulation    functions    care    disease    cells    tissue    difference    microfluidic    killing    leukaemia    responsive    treatments    fundamentals    act    patients    healthy    potent    mechanotransduction    therapy    immunosuppressive    selectively    supporting    tissues    clinical    horizon    employs    safety    secreting    immune    manner    reactive    therapies    effector    immunotherapy    enhanced    inducible    harnessing    strategies    transforming    suppression    health    cell    immunomodulatory    efficacy    infiltration    engineered    microenvironment    training    sites   

Project "MechanoIMM" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙499˙800 €
 EC max contribution 1˙499˙800 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2023-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 1˙499˙800.00

Map

 Project objective

Cancer immunotherapy harnessing the power of a patient’s immune system to fight cancer is transforming the standard-of-care for cancer. Adoptive cell therapy (ACT), a potent immunotherapy that directly infuses a large number of tumour-reactive T cells into patients, has elicited dramatic clinical responses in leukaemia patients recently. However, solid tumour remains a major challenge as tumour employs a number of strategies to prevent effector T cells reaching the tumour sites and attacking cancer by generating a highly immunosuppressive microenvironment. Current strategies are focused on controlling the immune system or the microenvironment using biochemical immunomodulatory reagents to enhance T cell based immunotherapy. Approaches exploiting biophysical and mechanical cues for immunomodulation are largely underappreciated. In this proposal, we aim to exploit mechanical immunoengineering strategies through biophysical cues to develop novel immune related treatments to enhance the efficacy and safety of adoptive T cell therapy for cancer. We will first develop a mechano-training approach to promote the T cell infiltration into tumour tissues using engineered microfluidic system for controlled force application on T cells in a high through-put manner. Second, we will develop a mechano-responsive nanoparticle delivery system to selectively deliver T-cell-supporting drugs in tumour to overcome the immune suppression in the microenvironment and enhance T cell functions for killing cancer. Third, we will develop mechano-inducible cytokine-secreting T cell therapies to augment the efficacy and minimize the toxicity of ACT by exploiting and targeting the difference in tissue stiffness between tumour and healthy tissues. This proposed project will open a new horizon for immunoengineering through biomechanical modulation of immunity for enhanced cancer immunotherapy and provide insight into the fundamentals of mechanotransduction in immune system in health and disease.

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The information about "MECHANOIMM" are provided by the European Opendata Portal: CORDIS opendata.

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