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MechanoIMM SIGNED

Mechanical Immunoengineering for Enhanced T-cell Immunotherapy

Total Cost €

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EC-Contrib. €

0

Partnership

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 MechanoIMM project word cloud

Explore the words cloud of the MechanoIMM project. It provides you a very rough idea of what is the project "MechanoIMM" about.

microfluidic    power    immune    fundamentals    enhanced    overcome    suppression    clinical    infiltration    dramatic    selectively    training    cues    prevent    largely    immunoengineering    reaching    care    immunosuppressive    transforming    mechanical    toxicity    potent    engineered    secreting    attacking    infuses    killing    immunotherapy    biophysical    effector    functions    immunomodulation    safety    tissues    health    inducible    nanoparticle    augment    cells    manner    patients    put    leukaemia    efficacy    immunity    difference    generating    reagents    responsive    healthy    biochemical    tissue    disease    patient    drugs    adoptive    employs    force    first    cell    therapies    harnessing    minimize    cytokine    cancer    sites    elicited    immunomodulatory    mechanotransduction    treatments    horizon    fight    therapy    reactive    microenvironment    mechano    underappreciated    stiffness    standard    act    solid    tumour    modulation    supporting    biomechanical    strategies   

Project "MechanoIMM" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙499˙800 €
 EC max contribution 1˙499˙800 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2023-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 1˙499˙800.00

Map

 Project objective

Cancer immunotherapy harnessing the power of a patient’s immune system to fight cancer is transforming the standard-of-care for cancer. Adoptive cell therapy (ACT), a potent immunotherapy that directly infuses a large number of tumour-reactive T cells into patients, has elicited dramatic clinical responses in leukaemia patients recently. However, solid tumour remains a major challenge as tumour employs a number of strategies to prevent effector T cells reaching the tumour sites and attacking cancer by generating a highly immunosuppressive microenvironment. Current strategies are focused on controlling the immune system or the microenvironment using biochemical immunomodulatory reagents to enhance T cell based immunotherapy. Approaches exploiting biophysical and mechanical cues for immunomodulation are largely underappreciated. In this proposal, we aim to exploit mechanical immunoengineering strategies through biophysical cues to develop novel immune related treatments to enhance the efficacy and safety of adoptive T cell therapy for cancer. We will first develop a mechano-training approach to promote the T cell infiltration into tumour tissues using engineered microfluidic system for controlled force application on T cells in a high through-put manner. Second, we will develop a mechano-responsive nanoparticle delivery system to selectively deliver T-cell-supporting drugs in tumour to overcome the immune suppression in the microenvironment and enhance T cell functions for killing cancer. Third, we will develop mechano-inducible cytokine-secreting T cell therapies to augment the efficacy and minimize the toxicity of ACT by exploiting and targeting the difference in tissue stiffness between tumour and healthy tissues. This proposed project will open a new horizon for immunoengineering through biomechanical modulation of immunity for enhanced cancer immunotherapy and provide insight into the fundamentals of mechanotransduction in immune system in health and disease.

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The information about "MECHANOIMM" are provided by the European Opendata Portal: CORDIS opendata.

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