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MoViD SIGNED

Brownian Motor Based Virus Detection

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

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Project "MoViD" data sheet

The following table provides information about the project.

Coordinator
IBM RESEARCH GMBH 

Organization address
address: SAEUMERSTRASSE 4
city: RUESCHLIKON
postcode: 8803
website: www.zurich.ibm.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IBM RESEARCH GMBH CH (RUESCHLIKON) coordinator 150˙000.00

Map

 Project objective

The detection of dilute populations of nanoparticles in microfluidics is difficult due to diffusion as the time limiting step to reach the sensor. Using active transport, we propose to build a proof of concept microfluidic device that reaches sub-attomolar detection sensitivity within an hour and at a device footprint of 1 cm. The active transport enables size separation of the particles into multiple channels and up-concentration in detection reservoirs for label free detection. At the end of the process the size-separated particles can be easily extracted for further downstream processing. The applied use case is the detection and quantification of virus in drinking water, a global health-critical challenge. A viral concentration of 10-100 particles is infectious in 2l of water consumed by a person, corresponding to a concentration of 10^(-22) molar. Traditional methods rely on multiple concentration steps followed by detection using molecular and/or culture based methods. Most common are adsorption/elution assays which co-concentrate and add contaminations that interfere with the downstream detection analysis. The detection methods are also often specific for the viral type and require a priori identification of the target virus. Metagenomic sequencing allows for general identification but lacks sensitivity. The proposed method will simplify and improve the process significantly. The viruses will be concentrated without damage of the virus shell and with a high rejection of the contamination present in the sample. All virus particles will be separated and sorted according to predefined size ranges into detection compartments on the chip, allowing for a parallel and quantitative marker-less detection on a single particle level. Specific identification is possible for future devices using (integrated) molecular methods with reduced cross-contamination and without a priori virus identification.

 Publications

year authors and title journal last update
List of publications.
2019 Stefan Fringes, C. Schwemmer, Colin D. Rawlings, Armin W. Knoll
Deterministic Deposition of Nanoparticles with Sub-10 nm Resolution
published pages: 8855-8861, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.9b03687
Nano Letters 19/12 2020-01-28

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The information about "MOVID" are provided by the European Opendata Portal: CORDIS opendata.

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