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NOVIRUSES2BRAIN SIGNED

''One size fits all'' unique drug to eradicate multiple viral species simultaneously from the central nervous system of co-infected individuals

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NOVIRUSES2BRAIN" data sheet

The following table provides information about the project.

Coordinator
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES 

Organization address
address: AVENIDA PROF EGAS MONIZ
city: LISBOA
postcode: 1649 028
website: www.imm.ul.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 3˙933˙965 €
 EC max contribution 3˙933˙965 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES PT (LISBOA) coordinator 2˙113˙125.00
2    UNIVERSIDAD POMPEU FABRA ES (BARCELONA) participant 1˙272˙840.00
3    SYNOVO GMBH DE (TUEBINGEN) participant 548˙000.00

Map

 Project objective

Viruses that infect the brain and other parts of the central nervous system are a worldwide threat of terrible dimensions. Viruses such as Zika, Dengue, Chikungunya, HIV or measles, for instance, are responsible for thousands of victims severely impaired at neurological level each year in the world. The most recent large scale threat in this domain was a Zika virus outbreak in South America. Zika virus, like Dengue virus or Chikungunya virus, is spread mainly by mosquitos of the genus Aedes. While Dengue and Chikungunya viruses, as many others, might causes diseases with severe neurological disorders, Zika virus is much more dreadful in this regard. When a pregnant woman is infected, the virus is able to translocate the blood-placental barrier and then the developing blood-brain barrier of the foetus, causing microcephaly and serious neurological disorders to newly born babies. Although co-infections with Aedes-borne viruses, such as the above mentioned Zika, Dengue and Chikungunya viruses, are likely because several viral species coexist in the same vector, the classical drug development strategies completely overlook this striking reality. Moreover, additional co-infections with HIV and measles virus, using other routes of infection, are also possible. A drug able to target a very large spectrum of viral species is urgently needed. Importantly, this drug must be able to traverse the blood-brain barrier and reach the viruses accumulated in the brain. NOVIRUSES2BRAIN is a project that aims at finding and selecting drug leads that are both efficacious and able to translocate the blood-placental and blood-brain barriers so that Zika, Dengue, Chikungunya and other viruses can be targeted across barriers, including during pregnancy. The project gathers the expertise of medicinal chemists, biochemists, drug development specialists and virologists to create drug leads able to clear all viral species from brain simultaneously.

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The information about "NOVIRUSES2BRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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