Explore the words cloud of the INTEGRATE project. It provides you a very rough idea of what is the project "INTEGRATE" about.
The following table provides information about the project.
UNIVERSITETET I OSLO
|Coordinator Country||Norway [NO]|
|Total cost||208˙400 €|
|EC max contribution||208˙400 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2018-12-01 to 2021-12-01|
Take a look of project's partnership.
An integrated hypothesis for cognitive and positive symptoms in schizophrenia:
Schizophrenia is a complex developmental brain disorder with three main clusters of symptoms: (i) positive (psychosis, delusions and hallucinations), (ii) negative (reduced motivation and social withdrawal), and (iii) cognitive (memory and executive function deficits). For the last 50 years, the only effective treatment has consisted of antipsychotics targeting dopamine receptors. Yet, antipsychotics control mostly the positive symptoms and are largely ineffective at treating other deficits.
It is frequently assumed that distinct pathophysiological mechanisms underlie different symptoms. Psychosis is associated with striatal hyperdopaminergia, probably due to abnormal activity of midbrain dopaminergic neurons. Yet cognitive deficits seem to arise from cortical excitation/inhibition unbalance. I propose to test, in a mice model, the hypothesis that striatal hyperdopaminergia results from dysfunctional cortical inhibition. If verified, this would suggest that normalizing cortical activity in schizophrenia might both restore cognitive function and prevent psychosis.
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The information about "INTEGRATE" are provided by the European Opendata Portal: CORDIS opendata.