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SEAROX SIGNED

Sulfur Enabled Annulations for Modular, Efficient and General Routes into Oxazoles

Total Cost €

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EC-Contrib. €

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Partnership

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 SEAROX project word cloud

Explore the words cloud of the SEAROX project. It provides you a very rough idea of what is the project "SEAROX" about.

broad    industries    base    pioneer    chemical    molecule    demand    regioselectivity    skills    catalysed    nucleophilic    reactions    er    nitrogen    influence    metal    activated    ubiquitous    combinations    host    intermolecular    functional    cross    readily    paul    screening    dr    utility    libraries    davies    academic    limits    selectivity    structurally    reactants    emerged    groups    translates    searox    heterocycles    unprecedented    biologically    complementary    preparations    active    preparation    drug    rd    practically    expertise    gold    space    heterocycle    accessible    substitution    annulations    nitrenoids    sulfur    energy    pharmaceutical    agrochemical    coupling    diversifiable    impart    economy    prakash    vital    sustainability    oxazoles    benefits    modular    species    alkynes    diverse    directing    optimal    phenotypic    catalysis    scaffold    probe    enhanced    donor    establishing    group    motifs    efficient    discovery    reactivity    equip    industrial    science    library    sekar    ps    patterns    stage    integrate    reaction    reducing   

Project "SEAROX" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 212˙933.00

Map

 Project objective

SEAROX will bring together the complementary expertise of Dr Prakash Sekar (ER, expertise in cross-coupling and directing effects in metal catalysis) with Dr Paul Davies (Host, expertise in gold catalysis, sulfur-based reaction development and nucleophilic nitrenoids) to pioneer the use of sulfur-based directing groups to establish optimal gold-catalysed annulations. SEAROX will deliver an efficient, modular and readily diversifiable method to access important motifs with broad utility in academic and industrial RD. By reducing the chemical and energy demand of complex molecule preparation, the European science base and economy benefits from enhanced sustainability. Nucleophilic nitrenoids have emerged as highly effective reactants for the preparation of the nitrogen-based heterocycles ubiquitous across biologically active species and vital to the pharmaceutical and agrochemical industries. The novel reactivity and high selectivity from such methods depend on using strongly donor-activated alkynes. However, as the donor group translates into the products it limits their application. SEAROX will access more general and practically accessible heterocycle preparations by addressing the problems of donor-substitution. This project will also influence the wider gold catalysis field by establishing how S-directing effects impart unprecedented regioselectivity in intermolecular reactions. New substitution patterns and functional group combinations are needed to better probe chemical space in early stage drug discovery and SEAROX will equip PS with the skills to integrate scaffold and library design aspects within the new methods to deliver focused libraries of structurally-diverse oxazoles for phenotypic screening.

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The information about "SEAROX" are provided by the European Opendata Portal: CORDIS opendata.

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