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SEAROX SIGNED

Sulfur Enabled Annulations for Modular, Efficient and General Routes into Oxazoles

Total Cost €

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EC-Contrib. €

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Partnership

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 SEAROX project word cloud

Explore the words cloud of the SEAROX project. It provides you a very rough idea of what is the project "SEAROX" about.

modular    industrial    scaffold    structurally    regioselectivity    ubiquitous    directing    catalysis    prakash    discovery    searox    preparations    science    activated    cross    sulfur    demand    space    benefits    motifs    selectivity    agrochemical    chemical    oxazoles    annulations    reactants    host    equip    er    nucleophilic    coupling    complementary    academic    libraries    groups    probe    reactivity    species    phenotypic    library    stage    preparation    pharmaceutical    diverse    nitrenoids    dr    reaction    drug    enhanced    molecule    influence    unprecedented    functional    sekar    broad    optimal    economy    heterocycle    impart    base    catalysed    combinations    accessible    heterocycles    efficient    diversifiable    translates    limits    substitution    metal    ps    integrate    utility    alkynes    donor    biologically    intermolecular    readily    screening    pioneer    energy    skills    reactions    nitrogen    group    establishing    gold    reducing    davies    emerged    active    paul    vital    expertise    rd    industries    patterns    practically    sustainability   

Project "SEAROX" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 212˙933.00

Map

 Project objective

SEAROX will bring together the complementary expertise of Dr Prakash Sekar (ER, expertise in cross-coupling and directing effects in metal catalysis) with Dr Paul Davies (Host, expertise in gold catalysis, sulfur-based reaction development and nucleophilic nitrenoids) to pioneer the use of sulfur-based directing groups to establish optimal gold-catalysed annulations. SEAROX will deliver an efficient, modular and readily diversifiable method to access important motifs with broad utility in academic and industrial RD. By reducing the chemical and energy demand of complex molecule preparation, the European science base and economy benefits from enhanced sustainability. Nucleophilic nitrenoids have emerged as highly effective reactants for the preparation of the nitrogen-based heterocycles ubiquitous across biologically active species and vital to the pharmaceutical and agrochemical industries. The novel reactivity and high selectivity from such methods depend on using strongly donor-activated alkynes. However, as the donor group translates into the products it limits their application. SEAROX will access more general and practically accessible heterocycle preparations by addressing the problems of donor-substitution. This project will also influence the wider gold catalysis field by establishing how S-directing effects impart unprecedented regioselectivity in intermolecular reactions. New substitution patterns and functional group combinations are needed to better probe chemical space in early stage drug discovery and SEAROX will equip PS with the skills to integrate scaffold and library design aspects within the new methods to deliver focused libraries of structurally-diverse oxazoles for phenotypic screening.

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The information about "SEAROX" are provided by the European Opendata Portal: CORDIS opendata.

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