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RAMEN TERMINATED

RAMan spectroscopy for tracking Exosome based delivery of Nutraceuticals

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 RAMEN project word cloud

Explore the words cloud of the RAMEN project. It provides you a very rough idea of what is the project "RAMEN" about.

skills    intestine    signature    iron    animal    cells    dublin    expand    milk    ramen    hypothesise    er    establishing    cytological    minimum    free    drug    spectroscopy    intestinal    observing    signatures    college    women    supplements    prevalent    cell    penetrating    molecular    forms    byrne    vitro    fellowship    supplementation    enterocytes    technique    expression    conversion    independent    protection    nagarajan    endocytosis    614    absorption    vehicles    children    hugh    nanoparticles    dr    tracked    receptor    direct    worldwide    monitoring    sounderya    exosomes    responsible    brayden    cytosol    live    body    nanomedical    expert    sized    investigator    mediated    usable    supplement    focas    ip    million    prof    raman    functional    university    200    peptides    models    tracking    doses    bioimaging    standard    david    herself    receptors    anaemia    expertise    circumvent    principal    functionalised    nanometer    designing    techniques    model    exosome    supervision    industry    label    nutraceuticals   

Project "RAMEN" data sheet

The following table provides information about the project.

Coordinator
TECHNOLOGICAL UNIVERSITY DUBLIN 

Organization address
address: NORTH CIRCULAR ROAD 191 PARK HOUSE GRANGEGORMAN
city: DUBLIN
postcode: D07 EWV4
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 196˙590 €
 EC max contribution 196˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-03   to  2021-06-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNOLOGICAL UNIVERSITY DUBLIN IE (DUBLIN) coordinator 196˙590.00

Map

 Project objective

The objective of RAMan spectroscopy for tracking Exosome based delivery of Nutraceuticals (RAMEN), is to design nanometer sized intestine targeted iron supplement delivery vehicles, based on milk derived exosomes to efficiently address anaemia prevalent among 614 million women and 200 million children worldwide. Specifically, enterocytes, which are cells responsible for iron absorption (receptor mediated endocytosis) and conversion to usable forms in the body, will be targeted, and the exosomes will be functionalised with cell penetrating peptides to circumvent endocytosis, facilitating direct delivery of the iron supplement to the cytosol. The direct delivery we hypothesise will help improve iron supplementation at low doses with minimum side effects and in cases with reduced expression of uptake receptors. This uptake by enterocytes will be tracked using Raman spectroscopy, a label-free live cell technique, observing the molecular signatures of exosomes and the changes in the signature of iron supplements, after delivery and conversion to usable forms in cells and animal free in vitro intestine model. This project will be implemented by Dr Sounderya Nagarajan (ER), who has expertise in functional nanoparticles for in vitro targeted bioimaging, under the supervision of Prof. Hugh J. Byrne (FOCAS Research Institute), who is an expert in Raman spectroscopy for cytological studies and drug delivery analyses in collaboration with Prof. David Brayden (University College Dublin) who is an expert in industry standard in vitro intestinal models. The fellowship will expand the skills of the ER in designing cell specific nanomedical/supplement delivery and label free monitoring techniques and her understanding of IP protection and project management, towards establishing herself as an independent principal investigator.

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The information about "RAMEN" are provided by the European Opendata Portal: CORDIS opendata.

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