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RAMEN TERMINATED

RAMan spectroscopy for tracking Exosome based delivery of Nutraceuticals

Total Cost €

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EC-Contrib. €

0

Partnership

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 RAMEN project word cloud

Explore the words cloud of the RAMEN project. It provides you a very rough idea of what is the project "RAMEN" about.

dr    molecular    vehicles    principal    supervision    supplement    industry    protection    er    nanomedical    614    cells    bioimaging    minimum    intestinal    endocytosis    sounderya    receptors    cytological    university    standard    mediated    model    dublin    nutraceuticals    exosomes    enterocytes    forms    expression    nagarajan    models    functionalised    skills    absorption    expertise    animal    200    technique    signature    live    expert    brayden    fellowship    david    tracked    doses    independent    worldwide    tracking    anaemia    conversion    cell    raman    cytosol    exosome    responsible    prevalent    women    direct    nanoparticles    supplementation    prof    focas    investigator    label    byrne    free    spectroscopy    drug    herself    body    expand    sized    vitro    hugh    monitoring    usable    iron    establishing    functional    children    ip    nanometer    million    designing    receptor    hypothesise    intestine    penetrating    ramen    signatures    college    peptides    milk    supplements    observing    circumvent    techniques   

Project "RAMEN" data sheet

The following table provides information about the project.

Coordinator
TECHNOLOGICAL UNIVERSITY DUBLIN 

Organization address
address: NORTH CIRCULAR ROAD 191 PARK HOUSE GRANGEGORMAN
city: DUBLIN
postcode: D07 EWV4
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 196˙590 €
 EC max contribution 196˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-03   to  2021-06-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNOLOGICAL UNIVERSITY DUBLIN IE (DUBLIN) coordinator 196˙590.00

Map

 Project objective

The objective of RAMan spectroscopy for tracking Exosome based delivery of Nutraceuticals (RAMEN), is to design nanometer sized intestine targeted iron supplement delivery vehicles, based on milk derived exosomes to efficiently address anaemia prevalent among 614 million women and 200 million children worldwide. Specifically, enterocytes, which are cells responsible for iron absorption (receptor mediated endocytosis) and conversion to usable forms in the body, will be targeted, and the exosomes will be functionalised with cell penetrating peptides to circumvent endocytosis, facilitating direct delivery of the iron supplement to the cytosol. The direct delivery we hypothesise will help improve iron supplementation at low doses with minimum side effects and in cases with reduced expression of uptake receptors. This uptake by enterocytes will be tracked using Raman spectroscopy, a label-free live cell technique, observing the molecular signatures of exosomes and the changes in the signature of iron supplements, after delivery and conversion to usable forms in cells and animal free in vitro intestine model. This project will be implemented by Dr Sounderya Nagarajan (ER), who has expertise in functional nanoparticles for in vitro targeted bioimaging, under the supervision of Prof. Hugh J. Byrne (FOCAS Research Institute), who is an expert in Raman spectroscopy for cytological studies and drug delivery analyses in collaboration with Prof. David Brayden (University College Dublin) who is an expert in industry standard in vitro intestinal models. The fellowship will expand the skills of the ER in designing cell specific nanomedical/supplement delivery and label free monitoring techniques and her understanding of IP protection and project management, towards establishing herself as an independent principal investigator.

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The information about "RAMEN" are provided by the European Opendata Portal: CORDIS opendata.

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