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RAMEN TERMINATED

RAMan spectroscopy for tracking Exosome based delivery of Nutraceuticals

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 RAMEN project word cloud

Explore the words cloud of the RAMEN project. It provides you a very rough idea of what is the project "RAMEN" about.

vehicles    vitro    brayden    tracked    usable    200    supplementation    hugh    live    receptor    er    ramen    cytological    technique    tracking    college    supervision    exosomes    functionalised    exosome    principal    byrne    forms    supplement    models    techniques    body    observing    standard    intestine    university    intestinal    enterocytes    prevalent    signatures    nanomedical    herself    milk    expertise    endocytosis    focas    receptors    industry    david    independent    worldwide    dublin    children    responsible    cell    nanoparticles    circumvent    minimum    prof    investigator    free    women    functional    establishing    designing    cytosol    nanometer    drug    raman    supplements    bioimaging    anaemia    million    sounderya    spectroscopy    iron    expand    doses    sized    penetrating    expert    fellowship    molecular    conversion    cells    animal    nutraceuticals    ip    absorption    peptides    label    expression    model    dr    skills    nagarajan    protection    hypothesise    monitoring    614    signature    mediated    direct   

Project "RAMEN" data sheet

The following table provides information about the project.

Coordinator
TECHNOLOGICAL UNIVERSITY DUBLIN 

Organization address
address: NORTH CIRCULAR ROAD 191 PARK HOUSE GRANGEGORMAN
city: DUBLIN
postcode: D07 EWV4
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 196˙590 €
 EC max contribution 196˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-03   to  2021-06-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNOLOGICAL UNIVERSITY DUBLIN IE (DUBLIN) coordinator 196˙590.00

Map

 Project objective

The objective of RAMan spectroscopy for tracking Exosome based delivery of Nutraceuticals (RAMEN), is to design nanometer sized intestine targeted iron supplement delivery vehicles, based on milk derived exosomes to efficiently address anaemia prevalent among 614 million women and 200 million children worldwide. Specifically, enterocytes, which are cells responsible for iron absorption (receptor mediated endocytosis) and conversion to usable forms in the body, will be targeted, and the exosomes will be functionalised with cell penetrating peptides to circumvent endocytosis, facilitating direct delivery of the iron supplement to the cytosol. The direct delivery we hypothesise will help improve iron supplementation at low doses with minimum side effects and in cases with reduced expression of uptake receptors. This uptake by enterocytes will be tracked using Raman spectroscopy, a label-free live cell technique, observing the molecular signatures of exosomes and the changes in the signature of iron supplements, after delivery and conversion to usable forms in cells and animal free in vitro intestine model. This project will be implemented by Dr Sounderya Nagarajan (ER), who has expertise in functional nanoparticles for in vitro targeted bioimaging, under the supervision of Prof. Hugh J. Byrne (FOCAS Research Institute), who is an expert in Raman spectroscopy for cytological studies and drug delivery analyses in collaboration with Prof. David Brayden (University College Dublin) who is an expert in industry standard in vitro intestinal models. The fellowship will expand the skills of the ER in designing cell specific nanomedical/supplement delivery and label free monitoring techniques and her understanding of IP protection and project management, towards establishing herself as an independent principal investigator.

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The information about "RAMEN" are provided by the European Opendata Portal: CORDIS opendata.

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