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RAMEN TERMINATED

RAMan spectroscopy for tracking Exosome based delivery of Nutraceuticals

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 RAMEN project word cloud

Explore the words cloud of the RAMEN project. It provides you a very rough idea of what is the project "RAMEN" about.

signatures    body    skills    receptor    supplementation    ramen    exosomes    responsible    molecular    brayden    dublin    absorption    free    forms    fellowship    exosome    children    women    cell    million    prevalent    signature    penetrating    vehicles    receptors    animal    cells    tracked    prof    expand    model    industry    focas    intestinal    principal    hypothesise    worldwide    milk    614    intestine    200    byrne    designing    nanoparticles    nanometer    vitro    protection    direct    spectroscopy    conversion    mediated    functionalised    expert    models    establishing    bioimaging    techniques    dr    usable    endocytosis    doses    college    raman    drug    nanomedical    functional    cytosol    peptides    expression    tracking    investigator    expertise    cytological    ip    enterocytes    nutraceuticals    live    anaemia    monitoring    label    technique    supplements    minimum    independent    sounderya    hugh    standard    nagarajan    david    herself    circumvent    university    supplement    sized    observing    er    supervision    iron   

Project "RAMEN" data sheet

The following table provides information about the project.

Coordinator
TECHNOLOGICAL UNIVERSITY DUBLIN 

Organization address
address: NORTH CIRCULAR ROAD 191 PARK HOUSE GRANGEGORMAN
city: DUBLIN
postcode: D07 EWV4
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 196˙590 €
 EC max contribution 196˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-03   to  2021-06-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNOLOGICAL UNIVERSITY DUBLIN IE (DUBLIN) coordinator 196˙590.00

Map

 Project objective

The objective of RAMan spectroscopy for tracking Exosome based delivery of Nutraceuticals (RAMEN), is to design nanometer sized intestine targeted iron supplement delivery vehicles, based on milk derived exosomes to efficiently address anaemia prevalent among 614 million women and 200 million children worldwide. Specifically, enterocytes, which are cells responsible for iron absorption (receptor mediated endocytosis) and conversion to usable forms in the body, will be targeted, and the exosomes will be functionalised with cell penetrating peptides to circumvent endocytosis, facilitating direct delivery of the iron supplement to the cytosol. The direct delivery we hypothesise will help improve iron supplementation at low doses with minimum side effects and in cases with reduced expression of uptake receptors. This uptake by enterocytes will be tracked using Raman spectroscopy, a label-free live cell technique, observing the molecular signatures of exosomes and the changes in the signature of iron supplements, after delivery and conversion to usable forms in cells and animal free in vitro intestine model. This project will be implemented by Dr Sounderya Nagarajan (ER), who has expertise in functional nanoparticles for in vitro targeted bioimaging, under the supervision of Prof. Hugh J. Byrne (FOCAS Research Institute), who is an expert in Raman spectroscopy for cytological studies and drug delivery analyses in collaboration with Prof. David Brayden (University College Dublin) who is an expert in industry standard in vitro intestinal models. The fellowship will expand the skills of the ER in designing cell specific nanomedical/supplement delivery and label free monitoring techniques and her understanding of IP protection and project management, towards establishing herself as an independent principal investigator.

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The information about "RAMEN" are provided by the European Opendata Portal: CORDIS opendata.

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