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IA-NANO SIGNED

Albumin particles for intra-articular delivery of celecoxib to treat osteoarthritic inflammation.

Total Cost €

EC-Contrib. €

Partnership

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IA-NANO project word cloud

Explore the words cloud of the IA-NANO project. It provides you a very rough idea of what is the project "IA-NANO" about.

source gain synoviocytes researcher biomarkers host suboptimal complete inject fourth hyaluronic molecules world mechanism wellbeing area supervisors biocompatible loaded pharmaceutics human repeated benefit oa anti shortcomings outcomes toxic inflamed commercial model therapy clearance screening osteoarthritis rat space rapid employability medications demographic primary steroidal curable inflammatory local ia albumin prescribed position joints 2020 edge concentration free un oral deciphered drug acting predicted reduce knee acid joint horizon translational though chronic ddss release particles good injections biodegradable experts societal corticosteroids cyclooxygenase cutting health inhibitor candidate efficacy topical disability line administration articular injected sustainable symptomatic bioassay celecoxib vitro load option

Project "IA-NANO" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Organization address address: BELFIELD city: DUBLIN postcode: 4 website: www.ucd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Total cost	196˙590 €
EC max contribution	196˙590 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2018
Funding Scheme	MSCA-IF-EF-ST
Starting year	2019
Duration (year-month-day)	from 2019-08-01 to 2021-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Organization address address: BELFIELD city: DUBLIN postcode: 4 website: www.ucd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	coordinator	196˙590.00

Map

Project objective

Osteoarthritis (OA) is the most common chronic condition of the joints and is predicted to become the fourth largest cause of disability in the world by 2020. Its complete mechanism is yet to be deciphered. Though it is not curable, several medications are prescribed to manage the symptomatic OA, of which the oral and topical medications have shortcomings and the better option is the intra-articular (IA) delivery of free corticosteroids and hyaluronic acid. However, IA delivery is challenging due to the rapid clearance of the free injected molecules from the joint space and outcomes are suboptimal in terms of efficacy and a need for repeated injections. Our objective therefore is to load a candidate drug in a long-acting delivery system and inject it directly into the inflamed knee of a rat model of OA, following in vitro bioassay screening in primary human synoviocytes. Thus, in this project, we propose to develop non-toxic, biocompatible and biodegradable albumin particles loaded with the non-steroidal anti-inflammatory cyclooxygenase-2 inhibitor, celecoxib. This method is expected to reduce the side-effects associated with oral administration of celecoxib. In addition, it will also increase the drug local concentration in the joint and the controlled release of the drug will lead to reduction of inflammatory biomarkers in joints. The project is in line with the EU’s Horizon 2020 Programme focus area - Health, Demographic Change and Wellbeing and UN Sustainable Development goal - Good Health and Well-Being. It will be carried out by the researcher and supervisors who are experts in DDSs development, OA therapy and translational pharmaceutics. Both the researcher and the host are expected to benefit in this collaboration and the researcher will gain experience that will increase her future employability. The project will have great societal impact and commercial potential and will also help increase Europe’s position as the leading source of cutting-edge research.

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The information about "IA-NANO" are provided by the European Opendata Portal: CORDIS opendata.