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IA-NANO SIGNED

Albumin particles for intra-articular delivery of celecoxib to treat osteoarthritic inflammation.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IA-NANO project word cloud

Explore the words cloud of the IA-NANO project. It provides you a very rough idea of what is the project "IA-NANO" about.

clearance    therapy    complete    concentration    inhibitor    ia    screening    acting    suboptimal    ddss    deciphered    edge    health    world    fourth    hyaluronic    injections    though    curable    option    rapid    osteoarthritis    position    2020    inflamed    joints    line    vitro    source    bioassay    employability    release    experts    anti    celecoxib    sustainable    host    reduce    disability    predicted    efficacy    knee    biodegradable    toxic    benefit    biocompatible    load    free    articular    oa    drug    symptomatic    particles    inflammatory    joint    topical    cutting    area    inject    primary    albumin    shortcomings    translational    horizon    synoviocytes    rat    molecules    administration    pharmaceutics    local    cyclooxygenase    societal    chronic    gain    steroidal    model    medications    loaded    oral    researcher    human    biomarkers    supervisors    corticosteroids    injected    demographic    mechanism    wellbeing    outcomes    prescribed    repeated    candidate    acid    good    commercial    un    space   

Project "IA-NANO" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN 

Organization address
address: BELFIELD
city: DUBLIN
postcode: 4
website: www.ucd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 196˙590 €
 EC max contribution 196˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) coordinator 196˙590.00

Map

 Project objective

Osteoarthritis (OA) is the most common chronic condition of the joints and is predicted to become the fourth largest cause of disability in the world by 2020. Its complete mechanism is yet to be deciphered. Though it is not curable, several medications are prescribed to manage the symptomatic OA, of which the oral and topical medications have shortcomings and the better option is the intra-articular (IA) delivery of free corticosteroids and hyaluronic acid. However, IA delivery is challenging due to the rapid clearance of the free injected molecules from the joint space and outcomes are suboptimal in terms of efficacy and a need for repeated injections. Our objective therefore is to load a candidate drug in a long-acting delivery system and inject it directly into the inflamed knee of a rat model of OA, following in vitro bioassay screening in primary human synoviocytes. Thus, in this project, we propose to develop non-toxic, biocompatible and biodegradable albumin particles loaded with the non-steroidal anti-inflammatory cyclooxygenase-2 inhibitor, celecoxib. This method is expected to reduce the side-effects associated with oral administration of celecoxib. In addition, it will also increase the drug local concentration in the joint and the controlled release of the drug will lead to reduction of inflammatory biomarkers in joints. The project is in line with the EU’s Horizon 2020 Programme focus area - Health, Demographic Change and Wellbeing and UN Sustainable Development goal - Good Health and Well-Being. It will be carried out by the researcher and supervisors who are experts in DDSs development, OA therapy and translational pharmaceutics. Both the researcher and the host are expected to benefit in this collaboration and the researcher will gain experience that will increase her future employability. The project will have great societal impact and commercial potential and will also help increase Europe’s position as the leading source of cutting-edge research.

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