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miR-IBD SIGNED

Fecal miRNAs, new mediators of host-microbiota interaction in Inflammatory Bowel Disease

Total Cost €

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EC-Contrib. €

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Partnership

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Project "miR-IBD" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 196˙707.00

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 Project objective

Growing evidences indicate that microRNAs (miRNAs) are present in various body fluids and contribute to cell-cell communication. My previous studies identified circulating miRNAs as efficient tool for the diagnosis and surveillance of Inflammatory Bowel Disease (IBD). Interestingly, miRNAs are secreted into the intestinal lumen where thousands of different bacterial species are present and confer important benefits to the host. This proximity prompted us to speculate that miRNAs and bacteria interact, playing a role in the host/microbiota relationship. My preliminary data generated to date demonstrate that fecal miRNAs are altered during intestinal inflammation in association with an alteration of microbiota composition, and we recently reported that exogenously administered miRNAs have the potential to alter microbiota composition and function. Here, our central hypothesis is that fecal miRNAs are mediators of host-microbiota interactions and therefore modulate intestinal inflammation. On the basis of this overarching hypothesis, I now propose to determine the role played by the intestinal microbiota in miRNA-mediated modulation of intestinal inflammation (objective 1: mechanism); Investigate the ability of specific miRNAs / anti-miRNAs to modulate intestinal inflammation. (objective 2: therapeutic) and to identify whether fecal miRNAs are indicators of microbiota and intestinal healthiness in IBD patients (objective 3: translational). We envision that the proposed experiments could identify a new role for miRNAs in manipulating the intestinal microbiota hence leading to the development of new therapeutic strategies.

 Publications

year authors and title journal last update
List of publications.
2019 Olivier Merlin-Zhang, Jun-Sik Jung, Emilie Viennois
In vitro Intestinal Epithelial Wound-healing Assays Using Electric Cell-Substrate Impedance Sensing Instrument
published pages: , ISSN: 2331-8325, DOI: 10.21769/bioprotoc.3351
BIO-PROTOCOL 9/17 2020-04-01
2020 Hirohito Abo, Benoit Chassaing, Akihito Harusato, Miguel Quiros, Jennifer C. Brazil, Vu L. Ngo, Emilie Viennois, Didier Merlin, Andrew T. Gewirtz, Asma Nusrat, Timothy L. Denning
Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-14258-z
Nature Communications 11/1 2020-04-01
2019 Jun-Sik Jung, Chunhua Yang, Emilie Viennois, Mingzhen Zhang, Didier Merlin
Isolation, Purification, and Characterization of Ginger-derived Nanoparticles (GDNPs) from Ginger, Rhizome of Zingiber officinale
published pages: , ISSN: 2331-8325, DOI: 10.21769/bioprotoc.3390
BIO-PROTOCOL 9/19 2020-04-01
2019 Emilie Viennois, Benoit Chassaing, Anika Tahsin, Adani Pujada, Lixin Wang, Andrew T. Gewirtz, Didier Merlin
Host-derived fecal microRNAs can indicate gut microbiota healthiness and ability to induce inflammation
published pages: 4542-4557, ISSN: 1838-7640, DOI: 10.7150/thno.35282
Theranostics 9/15 2020-04-01

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