Explore the words cloud of the miR-IBD project. It provides you a very rough idea of what is the project "miR-IBD" about.
The following table provides information about the project.
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
|Coordinator Country||France [FR]|
|Total cost||196˙707 €|
|EC max contribution||196˙707 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2019-10-01 to 2021-09-30|
Take a look of project's partnership.
|1||INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE||FR (PARIS)||coordinator||196˙707.00|
Growing evidences indicate that microRNAs (miRNAs) are present in various body fluids and contribute to cell-cell communication. My previous studies identified circulating miRNAs as efficient tool for the diagnosis and surveillance of Inflammatory Bowel Disease (IBD). Interestingly, miRNAs are secreted into the intestinal lumen where thousands of different bacterial species are present and confer important benefits to the host. This proximity prompted us to speculate that miRNAs and bacteria interact, playing a role in the host/microbiota relationship. My preliminary data generated to date demonstrate that fecal miRNAs are altered during intestinal inflammation in association with an alteration of microbiota composition, and we recently reported that exogenously administered miRNAs have the potential to alter microbiota composition and function. Here, our central hypothesis is that fecal miRNAs are mediators of host-microbiota interactions and therefore modulate intestinal inflammation. On the basis of this overarching hypothesis, I now propose to determine the role played by the intestinal microbiota in miRNA-mediated modulation of intestinal inflammation (objective 1: mechanism); Investigate the ability of specific miRNAs / anti-miRNAs to modulate intestinal inflammation. (objective 2: therapeutic) and to identify whether fecal miRNAs are indicators of microbiota and intestinal healthiness in IBD patients (objective 3: translational). We envision that the proposed experiments could identify a new role for miRNAs in manipulating the intestinal microbiota hence leading to the development of new therapeutic strategies.
|year||authors and title||journal||last update|
Olivier Merlin-Zhang, Jun-Sik Jung, Emilie Viennois
In vitro Intestinal Epithelial Wound-healing Assays Using Electric Cell-Substrate Impedance Sensing Instrument
published pages: , ISSN: 2331-8325, DOI: 10.21769/bioprotoc.3351
Hirohito Abo, Benoit Chassaing, Akihito Harusato, Miguel Quiros, Jennifer C. Brazil, Vu L. Ngo, Emilie Viennois, Didier Merlin, Andrew T. Gewirtz, Asma Nusrat, Timothy L. Denning
Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-14258-z
|Nature Communications 11/1||2020-04-01|
Jun-Sik Jung, Chunhua Yang, Emilie Viennois, Mingzhen Zhang, Didier Merlin
Isolation, Purification, and Characterization of Ginger-derived Nanoparticles (GDNPs) from Ginger, Rhizome of Zingiber officinale
published pages: , ISSN: 2331-8325, DOI: 10.21769/bioprotoc.3390
Emilie Viennois, Benoit Chassaing, Anika Tahsin, Adani Pujada, Lixin Wang, Andrew T. Gewirtz, Didier Merlin
Host-derived fecal microRNAs can indicate gut microbiota healthiness and ability to induce inflammation
published pages: 4542-4557, ISSN: 1838-7640, DOI: 10.7150/thno.35282
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