Opendata, web and dolomites

CAN-IT-BARRIERS SIGNED

Disruption of systemic and microenvironmental barriers to immunotherapy of antigenic tumors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 CAN-IT-BARRIERS project word cloud

Explore the words cloud of the CAN-IT-BARRIERS project. It provides you a very rough idea of what is the project "CAN-IT-BARRIERS" about.

combined    genetically    basis    inhibit    nonspecific    neo    patients    populations    breaking    expansion    helping    encode    circumvent    elicit    establishing    lack    immunotherapies    immunosuppression    keratinocytes    efficacious    immunogenic    ostensibly    survival    therapy    activation    expressing    producing    cd8    cancers    immunosuppressive    overarching    lay    pharmacologically    myeloid    impairing    nodes    concert    functional    cells    cytotoxic    eliminating    alone    complemented    infiltrating    modalities    hypothesis    barrier    attack    mouse    antigen    expression    multiple    lab    refractory    therapeutic    presenting    spleen    unprecedented    faceted    groundwork    hpv    oncogenes    immuno    models    probe    lymph    operative    microenvironment    tumors    corollary    actionable    mechanisms    infiltration    mediated    priori    poorly    types    efficacy    barriers    responsive    erect    spectrum    resistance    manifestation    ctls    ll    human    strategies    mostly    cancer    antigens    tumor    e6    orchestrating    oncogene    killing    oncoproteins    papillomavirus    lies    stimulatory    induction    benefit    adaptive    tumorigenesis    dendritic    reactive    solid    turn    systemic    marked    frontier    immunotherapy    immune    expanded   

Project "CAN-IT-BARRIERS" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 2˙500˙000.00

Map

 Project objective

The frontier in cancer therapy of orchestrating the immune system to attack tumors is producing unprecedented survival benefit in some patients. The corollary is lack of efficacy both in ostensibly responsive tumor types as well as others that are mostly non-responsive. The basis lies in pre-existing and adaptive resistance mechanisms that circumvent induction of tumor-reactive cytotoxic T cells (CTLs) capable of infiltrating solid tumors and eliminating cancer cells. A priori, cancers induced by expression of human papillomavirus oncogenes should be responsive to immunotherapy: these cancers encode immunogenic neo-antigens – the oncoproteins E6/7 – necessary for their manifestation. Rather, such tumors are poorly responsive to immunotherapies. Results from my lab and others using mouse models of HPV-induced cancer have established an actionable hypothesis: during tumorigenesis, such tumors erect multiple barriers to the induction, infiltration, and killing of cancer cells by tumor antigen-reactive CTLs. These include overarching systemic antigen-nonspecific immunosuppression mediated by expanded populations of myeloid cells in spleen and lymph nodes, complemented by immune response-impairing barriers operative in the tumor microenvironment. A spectrum of models will probe these barriers, genetically and pharmacologically, establishing their functional importance, alone and in concert. A major focus will be on how oncogene-expressing keratinocytes elicit a marked expansion of immunosuppressive myeloid cells in spleen and lymph nodes, and how these myeloid cells in turn inhibit development and activation of CD8 T cells and antigen-presenting dendritic cells. Then we’ll assess the therapeutic potential of barrier-breaking strategies combined with immuno-stimulatory modalities. This project will deliver new knowledge about multi-faceted barriers to immunotherapy in these refractory cancers, helping lay the groundwork for efficacious immunotherapy.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CAN-IT-BARRIERS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CAN-IT-BARRIERS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

InsideChromatin (2019)

Towards Realistic Modelling of Nucleosome Organization Inside Functional Chromatin Domains

Read More  

SuperH (2019)

Discovery and Characterization of Hydrogen-Based High-Temperature Superconductors

Read More  

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More