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CAN-IT-BARRIERS SIGNED

Disruption of systemic and microenvironmental barriers to immunotherapy of antigenic tumors

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EC-Contrib. €

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Partnership

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 CAN-IT-BARRIERS project word cloud

Explore the words cloud of the CAN-IT-BARRIERS project. It provides you a very rough idea of what is the project "CAN-IT-BARRIERS" about.

keratinocytes    survival    e6    immune    ll    establishing    priori    strategies    lay    neo    corollary    dendritic    models    microenvironment    impairing    marked    adaptive    attack    helping    lies    tumorigenesis    myeloid    combined    genetically    manifestation    cancers    presenting    papillomavirus    circumvent    stimulatory    antigen    basis    expressing    activation    faceted    nodes    efficacy    efficacious    turn    mouse    overarching    nonspecific    concert    therapy    resistance    oncogene    complemented    immunosuppression    killing    frontier    ostensibly    human    eliminating    barrier    ctls    immunosuppressive    groundwork    tumors    producing    therapeutic    barriers    immunotherapies    expansion    responsive    cells    modalities    spectrum    reactive    solid    types    unprecedented    cytotoxic    lack    poorly    infiltrating    induction    oncoproteins    expression    multiple    mediated    tumor    hpv    hypothesis    cancer    cd8    mostly    infiltration    benefit    lab    probe    actionable    lymph    breaking    functional    oncogenes    alone    inhibit    elicit    immunogenic    mechanisms    antigens    immunotherapy    patients    populations    expanded    encode    spleen    refractory    immuno    systemic    operative    pharmacologically    erect    orchestrating   

Project "CAN-IT-BARRIERS" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 2˙500˙000.00

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 Project objective

The frontier in cancer therapy of orchestrating the immune system to attack tumors is producing unprecedented survival benefit in some patients. The corollary is lack of efficacy both in ostensibly responsive tumor types as well as others that are mostly non-responsive. The basis lies in pre-existing and adaptive resistance mechanisms that circumvent induction of tumor-reactive cytotoxic T cells (CTLs) capable of infiltrating solid tumors and eliminating cancer cells. A priori, cancers induced by expression of human papillomavirus oncogenes should be responsive to immunotherapy: these cancers encode immunogenic neo-antigens – the oncoproteins E6/7 – necessary for their manifestation. Rather, such tumors are poorly responsive to immunotherapies. Results from my lab and others using mouse models of HPV-induced cancer have established an actionable hypothesis: during tumorigenesis, such tumors erect multiple barriers to the induction, infiltration, and killing of cancer cells by tumor antigen-reactive CTLs. These include overarching systemic antigen-nonspecific immunosuppression mediated by expanded populations of myeloid cells in spleen and lymph nodes, complemented by immune response-impairing barriers operative in the tumor microenvironment. A spectrum of models will probe these barriers, genetically and pharmacologically, establishing their functional importance, alone and in concert. A major focus will be on how oncogene-expressing keratinocytes elicit a marked expansion of immunosuppressive myeloid cells in spleen and lymph nodes, and how these myeloid cells in turn inhibit development and activation of CD8 T cells and antigen-presenting dendritic cells. Then we’ll assess the therapeutic potential of barrier-breaking strategies combined with immuno-stimulatory modalities. This project will deliver new knowledge about multi-faceted barriers to immunotherapy in these refractory cancers, helping lay the groundwork for efficacious immunotherapy.

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