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Neuroheart TERMINATED

Cardiovascular Molecular Imaging for Personalized Tailored Treatment

Total Cost €

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EC-Contrib. €

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Partnership

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 Neuroheart project word cloud

Explore the words cloud of the Neuroheart project. It provides you a very rough idea of what is the project "Neuroheart" about.

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Project "Neuroheart" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT 

Organization address
address: JOSEF-SCHNEIDER-STRASSE 2
city: WURZBURG
postcode: 97080
website: www.uk-wuerzburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 239˙860 €
 EC max contribution 239˙860 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT DE (WURZBURG) coordinator 239˙860.00
2    JOHNS HOPKINS UNIVERSITY US (BALTIMORE) partner 0.00

Map

 Project objective

Objectives of the proposal: Heart Failure (HF) is estimated to cost the EU economy €196 billion a year. Currently, patients are treated with the highest pharmaceutical doses of antiRAS agents, which cause severe side effects and reduce the patients’ quality of life. Moreover, treatment responses are highly variable. This study aims to enable imaging-guided treatment optimization by using a radiolabelled novel angiotensin 1 receptor (AT1) blocker analogue in a small animal model of myocardial infarction (MI). Positron emission tomography (PET) as a cutting-edge method of evaluating HF pathophysiology at a molecular level will be employed to optimize treatment. How the objectives will be achieved: MI will be obtained by ligation of the coronary artery in Wistar rats. Subsequently, PET imaging with a dedicated small animal system (mciroPET) will be performed. A multiple set of cardioneuronal PET tracers provided by the partner institution at Johns Hopkins University will be used to measure the extent of global and regional neurohumoral abnormalities in rat hearts following different degrees of ischemic insult. The relationship between neurohumoral system alterations and subsequent left ventricular remodelling will be determined by microPET and Magnetic Resonance Imaging to assess deterioration of ventricular geometric parameters. Using the novel AT1-ligand, imaging-guided dose-derived therapeutic concepts for Wistar rats will be established in vivo with the aim to transfer this technique to the clinic in a long term perspective. Relevance to the Work Programme: I envisage that in the future a single cardiac PET scan prior to treatment initiation will be sufficient to estimate the appropriate drug dose in any given HF patient. This new concept of individualized drug dose determination has the potential to lead to personalized treatment for one of the most frequent fatal and expensive diseases and thereby contributes to the reduction of the economic burden of the EU.

 Publications

year authors and title journal last update
List of publications.
2019 Rudolf A. Werner, Xinyu Chen, Steven P. Rowe, Constantin Lapa, Mehrbod S. Javadi, Takahiro Higuchi
Recent paradigm shifts in molecular cardiac imaging—Establishing precision cardiology through novel 18F-labeled PET radiotracers
published pages: , ISSN: 1050-1738, DOI: 10.1016/j.tcm.2019.02.007
Trends in Cardiovascular Medicine 2019-04-18
2018 Rudolf A. Werner, Ryohei Kobayashi, Mehrbod Som Javadi, Zoe Köck, Hiroshi Wakabayashi, Stefan Unterecker, Kenichi Nakajima, Constantin Lapa, Andreas Menke, Takahiro Higuchi
Impact of Novel Antidepressants on Cardiac 123 I-Metaiodobenzylguanidine Uptake: Experimental Studies on SK-N-SH Cells and Healthy Rabbits
published pages: 1099-1103, ISSN: 0161-5505, DOI: 10.2967/jnumed.117.206045
Journal of Nuclear Medicine 59/7 2019-03-12
2018 Rudolf A. Werner, Xinyu Chen, Mitsuru Hirano, Steven P. Rowe, Constantin Lapa, Mehrbod S. Javadi, Takahiro Higuchi
SPECT vs. PET in cardiac innervation imaging: clash of the titans
published pages: 293-303, ISSN: 2281-5872, DOI: 10.1007/s40336-018-0289-4
Clinical and Translational Imaging 6/4 2019-03-12
2018 Rudolf A. Werner, Xinyu Chen, Yoshifumi Maya, Christoph Eissler, Mitsuru Hirano, Naoko Nose, Hiroshi Wakabayashi, Constantin Lapa, Mehrbod S. Javadi, Takahiro Higuchi
The Impact of Ageing on 11C-Hydroxyephedrine Uptake in the Rat Heart
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-29509-0
Scientific Reports 8/1 2019-03-12
2018 Rudolf A Werner, Hiroshi Wakabayashi, Jochen Bauer, Claudia Schütz, Christina Zechmeister, Nobuyuki Hayakawa, Mehrbod S Javadi, Constantin Lapa, Roland Jahns, Süleyman Ergün, Valerie Jahns, Takahiro Higuchi
Longitudinal 18F-FDG PET imaging in a rat model of autoimmune myocarditis
published pages: , ISSN: 2047-2404, DOI: 10.1093/ehjci/jey119
European Heart Journal - Cardiovascular Imaging 2019-03-12
2018 Xinyu Chen, Mitsuru Hirano, Rudolf A. Werner, Michael Decker, Takahiro Higuchi
Novel 18 F-Labeled PET Imaging Agent FV45 Targeting the Renin–Angiotensin System
published pages: 10460-10470, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b01885
ACS Omega 3/9 2019-03-12
2018 Rudolf A. Werner
Cardiac innervation imaging as a risk stratification tool for potential device therapy candidates
published pages: , ISSN: 1071-3581, DOI: 10.1007/s12350-018-01475-0
Journal of Nuclear Cardiology 2019-03-12
2018 Rudolf A. Werner, Xinyu Chen, Steven P. Rowe, Constantin Lapa, Mehrbod S. Javadi, Takahiro Higuchi
Moving into the next era of PET myocardial perfusion imaging: introduction of novel 18F-labeled tracers
published pages: , ISSN: 1569-5794, DOI: 10.1007/s10554-018-1469-z
The International Journal of Cardiovascular Imaging 2019-03-12

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The information about "NEUROHEART" are provided by the European Opendata Portal: CORDIS opendata.

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