Neuroheart TERMINATED
Cardiovascular Molecular Imaging for Personalized Tailored Treatment
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the Neuroheart project. It provides you a very rough idea of what is the project "Neuroheart" about.
Project "Neuroheart" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Total cost | 239˙860 € |
| EC max contribution | 239˙860 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2015 |
| Funding Scheme | MSCA-IF-GF |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-01-01 to 2019-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT | DE (WURZBURG) | coordinator | 239˙860.00 |
| 2 | JOHNS HOPKINS UNIVERSITY | US (BALTIMORE) | partner | 0.00 |
Map
Project objective
Objectives of the proposal: Heart Failure (HF) is estimated to cost the EU economy €196 billion a year. Currently, patients are treated with the highest pharmaceutical doses of antiRAS agents, which cause severe side effects and reduce the patients’ quality of life. Moreover, treatment responses are highly variable. This study aims to enable imaging-guided treatment optimization by using a radiolabelled novel angiotensin 1 receptor (AT1) blocker analogue in a small animal model of myocardial infarction (MI). Positron emission tomography (PET) as a cutting-edge method of evaluating HF pathophysiology at a molecular level will be employed to optimize treatment. How the objectives will be achieved: MI will be obtained by ligation of the coronary artery in Wistar rats. Subsequently, PET imaging with a dedicated small animal system (mciroPET) will be performed. A multiple set of cardioneuronal PET tracers provided by the partner institution at Johns Hopkins University will be used to measure the extent of global and regional neurohumoral abnormalities in rat hearts following different degrees of ischemic insult. The relationship between neurohumoral system alterations and subsequent left ventricular remodelling will be determined by microPET and Magnetic Resonance Imaging to assess deterioration of ventricular geometric parameters. Using the novel AT1-ligand, imaging-guided dose-derived therapeutic concepts for Wistar rats will be established in vivo with the aim to transfer this technique to the clinic in a long term perspective. Relevance to the Work Programme: I envisage that in the future a single cardiac PET scan prior to treatment initiation will be sufficient to estimate the appropriate drug dose in any given HF patient. This new concept of individualized drug dose determination has the potential to lead to personalized treatment for one of the most frequent fatal and expensive diseases and thereby contributes to the reduction of the economic burden of the EU.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Rudolf A. Werner, Xinyu Chen, Steven P. Rowe, Constantin Lapa, Mehrbod S. Javadi, Takahiro Higuchi Recent paradigm shifts in molecular cardiac imaging—Establishing precision cardiology through novel 18F-labeled PET radiotracers published pages: , ISSN: 1050-1738, DOI: 10.1016/j.tcm.2019.02.007 |
Trends in Cardiovascular Medicine | 2019-04-18 |
| 2018 |
Rudolf A. Werner, Ryohei Kobayashi, Mehrbod Som Javadi, Zoe Köck, Hiroshi Wakabayashi, Stefan Unterecker, Kenichi Nakajima, Constantin Lapa, Andreas Menke, Takahiro Higuchi Impact of Novel Antidepressants on Cardiac 123 I-Metaiodobenzylguanidine Uptake: Experimental Studies on SK-N-SH Cells and Healthy Rabbits published pages: 1099-1103, ISSN: 0161-5505, DOI: 10.2967/jnumed.117.206045 |
Journal of Nuclear Medicine 59/7 | 2019-03-12 |
| 2018 |
Rudolf A. Werner, Xinyu Chen, Mitsuru Hirano, Steven P. Rowe, Constantin Lapa, Mehrbod S. Javadi, Takahiro Higuchi SPECT vs. PET in cardiac innervation imaging: clash of the titans published pages: 293-303, ISSN: 2281-5872, DOI: 10.1007/s40336-018-0289-4 |
Clinical and Translational Imaging 6/4 | 2019-03-12 |
| 2018 |
Rudolf A. Werner, Xinyu Chen, Yoshifumi Maya, Christoph Eissler, Mitsuru Hirano, Naoko Nose, Hiroshi Wakabayashi, Constantin Lapa, Mehrbod S. Javadi, Takahiro Higuchi The Impact of Ageing on 11C-Hydroxyephedrine Uptake in the Rat Heart published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-29509-0 |
Scientific Reports 8/1 | 2019-03-12 |
| 2018 |
Rudolf A Werner, Hiroshi Wakabayashi, Jochen Bauer, Claudia Schütz, Christina Zechmeister, Nobuyuki Hayakawa, Mehrbod S Javadi, Constantin Lapa, Roland Jahns, Süleyman Ergün, Valerie Jahns, Takahiro Higuchi Longitudinal 18F-FDG PET imaging in a rat model of autoimmune myocarditis published pages: , ISSN: 2047-2404, DOI: 10.1093/ehjci/jey119 |
European Heart Journal - Cardiovascular Imaging | 2019-03-12 |
| 2018 |
Xinyu Chen, Mitsuru Hirano, Rudolf A. Werner, Michael Decker, Takahiro Higuchi Novel 18 F-Labeled PET Imaging Agent FV45 Targeting the Renin–Angiotensin System published pages: 10460-10470, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b01885 |
ACS Omega 3/9 | 2019-03-12 |
| 2018 |
Rudolf A. Werner Cardiac innervation imaging as a risk stratification tool for potential device therapy candidates published pages: , ISSN: 1071-3581, DOI: 10.1007/s12350-018-01475-0 |
Journal of Nuclear Cardiology | 2019-03-12 |
| 2018 |
Rudolf A. Werner, Xinyu Chen, Steven P. Rowe, Constantin Lapa, Mehrbod S. Javadi, Takahiro Higuchi Moving into the next era of PET myocardial perfusion imaging: introduction of novel 18F-labeled tracers published pages: , ISSN: 1569-5794, DOI: 10.1007/s10554-018-1469-z |
The International Journal of Cardiovascular Imaging | 2019-03-12 |
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