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AL4BIOCH SIGNED

Assembly Lines for Biocombinatorial Chemistry

Total Cost €

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EC-Contrib. €

0

Partnership

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 AL4BIOCH project word cloud

Explore the words cloud of the AL4BIOCH project. It provides you a very rough idea of what is the project "AL4BIOCH" about.

genetic    underlying    minimal    elongation    drug    engineering    chemoenzymatic    divergent    cancer    sparse    linearly    combined    statins    module    biophysical    translating    combination    exceptional    collaborations    pks    representations    candidates    al2bioch    sequence    rational    biosynthetic    diversity    reveal    imaging    host    architecture    fundamental    functional    models    either    transfer    precursor    substrate    assembly    drugs    techniques    organization    compounds    anti    comprehensively    synthases    protein    employ    isolated    front    polyketide    purpose    interactions    synthesis    trapping    factories    chemical    collinearity    line    molecular    architectural    multiple    domains    electron    promised    natural    optical    microscopy    ipks    generation    modpks    directed    insights    encoded    biological    biology    intermodular    modern    iteratively    re    modular    bimodules    probes    lab    modification    architectures    biophysics    lines    potent    modules    engineered    cryo    antibiotics    act    polypeptide    opportunity    builds   

Project "AL4BIOCH" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT BASEL 

Organization address
address: PETERSPLATZ 1
city: BASEL
postcode: 4051
website: www.unibas.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 203˙149 €
 EC max contribution 203˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT BASEL CH (BASEL) coordinator 203˙149.00

Map

 Project objective

Polyketide Synthases (PKS) are biological factories for the production of potent natural products, including antibiotics, anti‐cancer drugs, statins and further drugs. The exceptional chemical diversity generated by PKS is encoded in their modular architecture. The domains required for one step of precursor elongation and modification are combined into a functional polypeptide module. PKS modules can either act iteratively (iPKS) or in a linearly organized assembly line of multiple modules (modPKS). The collinearity between synthesis and protein sequence in modPKS promised the opportunity for rational re‐engineering of PKS at the genetic level in order to produce novel compounds. However, information on functional protein-protein interactions and substrate transfer in PKS beyond the level of isolated domains is sparse and divergent architectural models of module organization have been proposed. In the AL2BIOCH project, we aim to reveal the fundamental intermodular assembly line organization underlying the unique biosynthetic generation of chemical diversity by modPKS. For this purpose, we employ cryo-electron microscopy to comprehensively study the organization of modPKS bimodules as minimal representations of assembly lines organization. In combination with functional analysis, biophysical studies and chemoenzymatic trapping we address the architectures underlying directed substrate transfer. The research builds on modern and rapidly evolving techniques, including cryo electron microscopy, advanced optical imaging and biophysics, as well as chemical probes, which are most relevant for front-line molecular biology research. Success in this project will allow the host lab and organization to establish new collaborations for translating insights on modPKS architecture for the design of novel or re-engineered assembly lines for the generation of advanced chemical compounds and drug candidates.

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The information about "AL4BIOCH" are provided by the European Opendata Portal: CORDIS opendata.

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