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AL4BIOCH SIGNED

Assembly Lines for Biocombinatorial Chemistry

Total Cost €

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EC-Contrib. €

0

Partnership

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 AL4BIOCH project word cloud

Explore the words cloud of the AL4BIOCH project. It provides you a very rough idea of what is the project "AL4BIOCH" about.

multiple    architectural    transfer    rational    synthesis    representations    chemical    generation    architecture    host    protein    collaborations    al2bioch    synthases    biosynthetic    employ    diversity    optical    modpks    probes    divergent    cryo    ipks    combined    re    functional    linearly    collinearity    statins    genetic    modern    fundamental    line    natural    modular    potent    interactions    isolated    engineered    insights    antibiotics    imaging    reveal    electron    underlying    builds    pks    encoded    comprehensively    factories    cancer    elongation    chemoenzymatic    engineering    substrate    either    combination    polypeptide    domains    modules    molecular    iteratively    front    assembly    bimodules    biological    promised    anti    models    purpose    precursor    techniques    architectures    biophysical    act    compounds    drugs    sequence    sparse    minimal    biophysics    trapping    microscopy    directed    candidates    drug    lab    polyketide    exceptional    organization    lines    opportunity    biology    translating    modification    intermodular    module   

Project "AL4BIOCH" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT BASEL 

Organization address
address: PETERSPLATZ 1
city: BASEL
postcode: 4051
website: www.unibas.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 203˙149 €
 EC max contribution 203˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT BASEL CH (BASEL) coordinator 203˙149.00

Map

 Project objective

Polyketide Synthases (PKS) are biological factories for the production of potent natural products, including antibiotics, anti‐cancer drugs, statins and further drugs. The exceptional chemical diversity generated by PKS is encoded in their modular architecture. The domains required for one step of precursor elongation and modification are combined into a functional polypeptide module. PKS modules can either act iteratively (iPKS) or in a linearly organized assembly line of multiple modules (modPKS). The collinearity between synthesis and protein sequence in modPKS promised the opportunity for rational re‐engineering of PKS at the genetic level in order to produce novel compounds. However, information on functional protein-protein interactions and substrate transfer in PKS beyond the level of isolated domains is sparse and divergent architectural models of module organization have been proposed. In the AL2BIOCH project, we aim to reveal the fundamental intermodular assembly line organization underlying the unique biosynthetic generation of chemical diversity by modPKS. For this purpose, we employ cryo-electron microscopy to comprehensively study the organization of modPKS bimodules as minimal representations of assembly lines organization. In combination with functional analysis, biophysical studies and chemoenzymatic trapping we address the architectures underlying directed substrate transfer. The research builds on modern and rapidly evolving techniques, including cryo electron microscopy, advanced optical imaging and biophysics, as well as chemical probes, which are most relevant for front-line molecular biology research. Success in this project will allow the host lab and organization to establish new collaborations for translating insights on modPKS architecture for the design of novel or re-engineered assembly lines for the generation of advanced chemical compounds and drug candidates.

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The information about "AL4BIOCH" are provided by the European Opendata Portal: CORDIS opendata.

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