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DoReMI SIGNED

Dominating redox mechanisms in iron-mediated C-C bond formations: reactivity, new paradigms and applications

Total Cost €

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EC-Contrib. €

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Partnership

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 DoReMI project word cloud

Explore the words cloud of the DoReMI project. It provides you a very rough idea of what is the project "DoReMI" about.

catalysis    organometallic    context    economy    ubiquity    first    breakthroughs    doremi    formations    limitations    atom    noble    methodology    electrophiles    redox    spin    reaction    cross    rely    decades    governed    appears    mediated    materials    cheap    sacrificial    unfunctionalized    reactants    turned    poor    activated    metal    complexity    shedding    gathered    wp1    hydrocarbons    agrochemicals    economical    organoirons    scope    envisioned    pharmaceuticals    fe    last    derivatives    bond    pitfalls    due    pivotal    overtaking    light    reactions    reagents    reactivity    active    intermediates    economic    metalation    strategies    wp2    diverse    efficient    intermediate    unveiled    advantage    coupling    toxicity    catalytic    aforementioned    stoichiometric    environmentally    functionalization    alternative    oxidants    catalysts    iron    incredible    organoiron    substrates    mechanistic    time    organometallics    dominating    synthetic    activation    thanks    suffer    wp3    applicable   

Project "DoReMI" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙398˙620 €
 EC max contribution 1˙398˙620 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙398˙620.00

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 Project objective

Due to the ubiquity of the C-C bond in diverse areas such as pharmaceuticals, agrochemicals or materials, development of atom-economical and efficient methods ensuring its formation is an active research field. This field witnessed incredible breakthroughs during the last decades, especially thanks to organometallic catalysis applied to cross-coupling or C-H activation methods. However, the most efficient C-C bond formation reactions rely on noble-metal catalysts, which lead to economic and toxicity issues. Iron catalysis appears as a promising alternative, since this metal is cheap and environmentally-friendly. Yet, current methods of Fe-mediated C-C bond formation suffer from strong scope limitations and lead to processes with a poor atom economy, as they often require stoichiometric organometallics or sacrificial reactants (metalation reagents, or oxidants). Dominating the reactivity of the C-Fe bond is pivotal to address those issues, since organoiron derivatives are key intermediates in Fe-mediated C-C bond formations. This reactivity is rich and complex, and is governed both by redox and spin effects. The DoReMI project aims to use this complexity as an advantage to develop new synthetic strategies, which cannot be envisioned with noble metal catalysis, aiming at overtaking the aforementioned pitfalls. In a first work package (WP1), the mechanistic features of the reaction of organoirons with electrophiles will be unveiled, shedding light on the reactivity of the C-Fe bond in a C-C bond formation context. WP2 will show for the first time that a stoichiometric C-H functionalization reaction between non-activated hydrocarbons and electrophiles can be achieved via the formation of an organoiron intermediate. Using the results gathered in WP1 and WP2, WP3 will demonstrate that this C-H functionalization methodology can be turned into an efficient catalytic method applicable to both unfunctionalized C-H substrates and to targets of synthetic interest.

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