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DoReMI SIGNED

Dominating redox mechanisms in iron-mediated C-C bond formations: reactivity, new paradigms and applications

Total Cost €

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EC-Contrib. €

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Partnership

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 DoReMI project word cloud

Explore the words cloud of the DoReMI project. It provides you a very rough idea of what is the project "DoReMI" about.

formations    derivatives    electrophiles    diverse    mechanistic    first    catalysis    gathered    bond    metal    envisioned    unveiled    strategies    redox    fe    activation    organoiron    doremi    mediated    governed    scope    pitfalls    aforementioned    economy    activated    turned    suffer    sacrificial    context    complexity    decades    reaction    organometallic    stoichiometric    light    ubiquity    advantage    poor    thanks    wp2    intermediates    rely    time    incredible    wp1    economic    shedding    functionalization    overtaking    metalation    pivotal    intermediate    synthetic    breakthroughs    methodology    hydrocarbons    reagents    cheap    reactivity    reactions    organoirons    catalysts    atom    limitations    appears    applicable    materials    due    alternative    efficient    coupling    spin    noble    economical    unfunctionalized    active    toxicity    organometallics    reactants    catalytic    last    agrochemicals    iron    substrates    environmentally    oxidants    wp3    pharmaceuticals    dominating    cross   

Project "DoReMI" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙398˙620 €
 EC max contribution 1˙398˙620 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙398˙620.00

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 Project objective

Due to the ubiquity of the C-C bond in diverse areas such as pharmaceuticals, agrochemicals or materials, development of atom-economical and efficient methods ensuring its formation is an active research field. This field witnessed incredible breakthroughs during the last decades, especially thanks to organometallic catalysis applied to cross-coupling or C-H activation methods. However, the most efficient C-C bond formation reactions rely on noble-metal catalysts, which lead to economic and toxicity issues. Iron catalysis appears as a promising alternative, since this metal is cheap and environmentally-friendly. Yet, current methods of Fe-mediated C-C bond formation suffer from strong scope limitations and lead to processes with a poor atom economy, as they often require stoichiometric organometallics or sacrificial reactants (metalation reagents, or oxidants). Dominating the reactivity of the C-Fe bond is pivotal to address those issues, since organoiron derivatives are key intermediates in Fe-mediated C-C bond formations. This reactivity is rich and complex, and is governed both by redox and spin effects. The DoReMI project aims to use this complexity as an advantage to develop new synthetic strategies, which cannot be envisioned with noble metal catalysis, aiming at overtaking the aforementioned pitfalls. In a first work package (WP1), the mechanistic features of the reaction of organoirons with electrophiles will be unveiled, shedding light on the reactivity of the C-Fe bond in a C-C bond formation context. WP2 will show for the first time that a stoichiometric C-H functionalization reaction between non-activated hydrocarbons and electrophiles can be achieved via the formation of an organoiron intermediate. Using the results gathered in WP1 and WP2, WP3 will demonstrate that this C-H functionalization methodology can be turned into an efficient catalytic method applicable to both unfunctionalized C-H substrates and to targets of synthetic interest.

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