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EVEREST SIGNED

Extracellular Vesicles for Bone Regeneration – alternatives to Stem-cell Therapy

Total Cost €

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EC-Contrib. €

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Partnership

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 EVEREST project word cloud

Explore the words cloud of the EVEREST project. It provides you a very rough idea of what is the project "EVEREST" about.

substrate    reduce    therapies    regeneration    mesenchymal    edge    cell    extracellular    progressing    bioactive    transport    replaced    modulate    lipids    culture    pain    therapeutic    frontier    critical    hypoxia    bone    everest    shelf    answering    ev    correct    environment    release    stem    attributed    responsible    platform    functionalized    tested    handle    msc    mscs    firstly    potency    medicine    elasticity    delineate    induce    resection    permit    secreted    benefits    answer    nanoparticles    cues    mechanical    anatomically    cancerous    defects    free    therapy    proteins    environments    treatment    vivo    questions    exclusion    harvest    ground    donors    soluble    potent    hypothesis    regenerative    cutting    cargo    nucleic    manner    printing    off    fabricated    diseases    3d    dynamic    breaking    favorable    separates    replacements    metabolic    harnessing    cells    employed    acids    trauma    reported    embark    constructs    revolutionize    stress    vesicles    human    collection    hypotheses    evs    marrow    secretome    size    heterogeneity    healing    tumors    chromatography    elimination    sustained    intelligent   

Project "EVEREST" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙925 €
 EC max contribution 1˙499˙925 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙499˙925.00

Map

 Project objective

The therapeutic benefits of mesenchymal stem cells (MSCs), the state-of-the-art treatment for healing bone defects following trauma, resection of cancerous bone tumors, or metabolic bone diseases, has been attributed to their secreted factors. The regenerative potential of MSC-secreted extracellular vesicles (EVs), nanoparticles which deliver bioactive cargo (nucleic acids, proteins, and lipids) between cells, has recently been reported. The applicant will embark upon frontier research with the objective of progressing beyond the state-of-the-art, by harnessing the therapeutic effects of MSCs, but in a cutting-edge, cell-free manner, by developing high potency EV-based bone replacements. This objective will be addressed by firstly testing novel hypotheses to delineate how culture environments, specifically mechanical cues (substrate elasticity and 3D dynamic), hypoxia, and cell stress can modulate the cargo of EVs secreted by MSC. Size exclusion chromatography, which separates EVs from soluble proteins will be employed. Heterogeneity of EV cargo and functionality between human MSC donors will also be evaluated. Answering these hypotheses will permit the intelligent design of targeted EV therapies. The hypothesis that EV-functionalized constructs, fabricated by 3D-printing, will lead to controlled and sustained release of EVs and induce bone formation in vivo will best tested. Together, this will answer critical questions, namely the most favorable environment for collection of potent EVs for regenerative medicine, which secretome component (EV, soluble factors) is responsible for bone regeneration, and whether MSC cell therapy can be replaced by cell-free EVs. EVEREST will develop a platform for targeted EV delivery in ground-breaking, easy to transport and handle, ‘off-the-shelf’ anatomically correct constructs, which have the potential to reduce pain by elimination of bone or bone marrow harvest, and revolutionize the treatment of bone defects.

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The information about "EVEREST" are provided by the European Opendata Portal: CORDIS opendata.

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