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EVEREST SIGNED
Extracellular Vesicles for Bone Regeneration – alternatives to Stem-cell Therapy
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0EVEREST project word cloud
Explore the words cloud of the EVEREST project. It provides you a very rough idea of what is the project "EVEREST" about.
modulate
defects
elimination
attributed
induce
potency
questions
regenerative
breaking
harnessing
trauma
hypoxia
embark
ev
revolutionize
sustained
soluble
collection
size
critical
evs
treatment
elasticity
extracellular
bioactive
healing
acids
resection
permit
firstly
hypothesis
transport
diseases
secretome
tumors
bone
regeneration
marrow
answer
heterogeneity
secreted
therapeutic
potent
printing
3d
tested
cutting
free
handle
benefits
responsible
off
mscs
nucleic
platform
everest
employed
release
culture
cargo
pain
correct
chromatography
human
fabricated
replaced
reduce
vivo
favorable
environment
progressing
separates
hypotheses
intelligent
delineate
lipids
constructs
cells
functionalized
mesenchymal
exclusion
msc
stress
edge
cues
stem
cell
therapy
harvest
anatomically
frontier
answering
proteins
vesicles
replacements
cancerous
shelf
medicine
ground
dynamic
therapies
reported
manner
donors
mechanical
substrate
metabolic
nanoparticles
environments
Project "EVEREST" data sheet
The following table provides information about the project.
| Coordinator |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Organization address contact info |
| Coordinator Country | France [FR] |
| Total cost | 1˙499˙925 € |
| EC max contribution | 1˙499˙925 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2019-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-04-01 to 2025-03-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE | FR (PARIS) | coordinator | 1˙499˙925.00 |
Map
Project objective
The therapeutic benefits of mesenchymal stem cells (MSCs), the state-of-the-art treatment for healing bone defects following trauma, resection of cancerous bone tumors, or metabolic bone diseases, has been attributed to their secreted factors. The regenerative potential of MSC-secreted extracellular vesicles (EVs), nanoparticles which deliver bioactive cargo (nucleic acids, proteins, and lipids) between cells, has recently been reported. The applicant will embark upon frontier research with the objective of progressing beyond the state-of-the-art, by harnessing the therapeutic effects of MSCs, but in a cutting-edge, cell-free manner, by developing high potency EV-based bone replacements. This objective will be addressed by firstly testing novel hypotheses to delineate how culture environments, specifically mechanical cues (substrate elasticity and 3D dynamic), hypoxia, and cell stress can modulate the cargo of EVs secreted by MSC. Size exclusion chromatography, which separates EVs from soluble proteins will be employed. Heterogeneity of EV cargo and functionality between human MSC donors will also be evaluated. Answering these hypotheses will permit the intelligent design of targeted EV therapies. The hypothesis that EV-functionalized constructs, fabricated by 3D-printing, will lead to controlled and sustained release of EVs and induce bone formation in vivo will best tested. Together, this will answer critical questions, namely the most favorable environment for collection of potent EVs for regenerative medicine, which secretome component (EV, soluble factors) is responsible for bone regeneration, and whether MSC cell therapy can be replaced by cell-free EVs. EVEREST will develop a platform for targeted EV delivery in ground-breaking, easy to transport and handle, ‘off-the-shelf’ anatomically correct constructs, which have the potential to reduce pain by elimination of bone or bone marrow harvest, and revolutionize the treatment of bone defects.
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The information about "EVEREST" are provided by the European Opendata Portal: CORDIS opendata.
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