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EVEREST SIGNED

Extracellular Vesicles for Bone Regeneration – alternatives to Stem-cell Therapy

Total Cost €

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EC-Contrib. €

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Partnership

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 EVEREST project word cloud

Explore the words cloud of the EVEREST project. It provides you a very rough idea of what is the project "EVEREST" about.

edge    acids    replacements    evs    questions    transport    vivo    heterogeneity    extracellular    trauma    breaking    fabricated    treatment    stress    attributed    3d    embark    reported    stem    correct    culture    nucleic    bioactive    diseases    printing    therapy    msc    metabolic    reduce    healing    replaced    regeneration    intelligent    defects    lipids    frontier    elimination    secreted    tumors    human    dynamic    secretome    harnessing    free    cancerous    platform    induce    medicine    regenerative    release    exclusion    nanoparticles    potency    size    permit    chromatography    mscs    pain    marrow    environments    resection    constructs    therapeutic    employed    cell    elasticity    everest    progressing    hypothesis    sustained    separates    answering    cargo    collection    mechanical    soluble    hypotheses    modulate    handle    tested    donors    functionalized    bone    anatomically    firstly    ground    proteins    substrate    ev    cutting    vesicles    environment    benefits    mesenchymal    therapies    responsible    revolutionize    favorable    off    manner    hypoxia    answer    critical    delineate    harvest    cells    potent    shelf    cues   

Project "EVEREST" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙925 €
 EC max contribution 1˙499˙925 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙499˙925.00

Map

 Project objective

The therapeutic benefits of mesenchymal stem cells (MSCs), the state-of-the-art treatment for healing bone defects following trauma, resection of cancerous bone tumors, or metabolic bone diseases, has been attributed to their secreted factors. The regenerative potential of MSC-secreted extracellular vesicles (EVs), nanoparticles which deliver bioactive cargo (nucleic acids, proteins, and lipids) between cells, has recently been reported. The applicant will embark upon frontier research with the objective of progressing beyond the state-of-the-art, by harnessing the therapeutic effects of MSCs, but in a cutting-edge, cell-free manner, by developing high potency EV-based bone replacements. This objective will be addressed by firstly testing novel hypotheses to delineate how culture environments, specifically mechanical cues (substrate elasticity and 3D dynamic), hypoxia, and cell stress can modulate the cargo of EVs secreted by MSC. Size exclusion chromatography, which separates EVs from soluble proteins will be employed. Heterogeneity of EV cargo and functionality between human MSC donors will also be evaluated. Answering these hypotheses will permit the intelligent design of targeted EV therapies. The hypothesis that EV-functionalized constructs, fabricated by 3D-printing, will lead to controlled and sustained release of EVs and induce bone formation in vivo will best tested. Together, this will answer critical questions, namely the most favorable environment for collection of potent EVs for regenerative medicine, which secretome component (EV, soluble factors) is responsible for bone regeneration, and whether MSC cell therapy can be replaced by cell-free EVs. EVEREST will develop a platform for targeted EV delivery in ground-breaking, easy to transport and handle, ‘off-the-shelf’ anatomically correct constructs, which have the potential to reduce pain by elimination of bone or bone marrow harvest, and revolutionize the treatment of bone defects.

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The information about "EVEREST" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-08-15 6:44:45) correctly updated