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EVEREST SIGNED

Extracellular Vesicles for Bone Regeneration – alternatives to Stem-cell Therapy

Total Cost €

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EC-Contrib. €

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Partnership

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 EVEREST project word cloud

Explore the words cloud of the EVEREST project. It provides you a very rough idea of what is the project "EVEREST" about.

bone    nanoparticles    therapy    trauma    soluble    attributed    mesenchymal    correct    tumors    replacements    reported    embark    revolutionize    frontier    printing    ev    environment    potency    intelligent    answering    treatment    potent    stem    exclusion    breaking    cutting    regeneration    everest    secreted    induce    environments    mechanical    vivo    hypotheses    defects    separates    hypoxia    secretome    resection    progressing    msc    tested    extracellular    cancerous    responsible    medicine    marrow    transport    employed    nucleic    questions    manner    human    vesicles    mscs    healing    3d    delineate    modulate    cell    free    critical    substrate    evs    constructs    culture    platform    therapeutic    chromatography    heterogeneity    harnessing    shelf    donors    firstly    favorable    acids    elasticity    regenerative    metabolic    release    collection    harvest    bioactive    fabricated    functionalized    lipids    diseases    hypothesis    off    replaced    cargo    sustained    reduce    stress    answer    elimination    anatomically    therapies    cues    handle    proteins    size    cells    dynamic    benefits    ground    permit    edge    pain   

Project "EVEREST" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙925 €
 EC max contribution 1˙499˙925 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙499˙925.00

Map

 Project objective

The therapeutic benefits of mesenchymal stem cells (MSCs), the state-of-the-art treatment for healing bone defects following trauma, resection of cancerous bone tumors, or metabolic bone diseases, has been attributed to their secreted factors. The regenerative potential of MSC-secreted extracellular vesicles (EVs), nanoparticles which deliver bioactive cargo (nucleic acids, proteins, and lipids) between cells, has recently been reported. The applicant will embark upon frontier research with the objective of progressing beyond the state-of-the-art, by harnessing the therapeutic effects of MSCs, but in a cutting-edge, cell-free manner, by developing high potency EV-based bone replacements. This objective will be addressed by firstly testing novel hypotheses to delineate how culture environments, specifically mechanical cues (substrate elasticity and 3D dynamic), hypoxia, and cell stress can modulate the cargo of EVs secreted by MSC. Size exclusion chromatography, which separates EVs from soluble proteins will be employed. Heterogeneity of EV cargo and functionality between human MSC donors will also be evaluated. Answering these hypotheses will permit the intelligent design of targeted EV therapies. The hypothesis that EV-functionalized constructs, fabricated by 3D-printing, will lead to controlled and sustained release of EVs and induce bone formation in vivo will best tested. Together, this will answer critical questions, namely the most favorable environment for collection of potent EVs for regenerative medicine, which secretome component (EV, soluble factors) is responsible for bone regeneration, and whether MSC cell therapy can be replaced by cell-free EVs. EVEREST will develop a platform for targeted EV delivery in ground-breaking, easy to transport and handle, ‘off-the-shelf’ anatomically correct constructs, which have the potential to reduce pain by elimination of bone or bone marrow harvest, and revolutionize the treatment of bone defects.

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The information about "EVEREST" are provided by the European Opendata Portal: CORDIS opendata.

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