EMOLEARN

Emotional learning and extinction: integration of central and peripheral neural correlates

Coordinatore	WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER    more  Organization address address: SCHLOSSPLATZ 2 city: MUENSTER postcode: 48149 contact info Titolo: Mr. Nome: Ingo Cognome: Niendorf Email: send email Telefono: +49 251 835 5881 Fax: +49 251 835 4035
Nazionalità Coordinatore	Germany [DE]
Totale costo	121˙800 €
EC contributo	100˙800 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IRSES
Funding Scheme	MC-IRSES
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-11-01   -   2015-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER  Organization address address: SCHLOSSPLATZ 2 city: MUENSTER postcode: 48149 contact info Titolo: Mr. Nome: Ingo Cognome: Niendorf Email: send email Telefono: +49 251 835 5881 Fax: +49 251 835 4035	DE (MUENSTER)	coordinator	50˙400.00
2	UNIVERSITAT JAUME I DE CASTELLON  Organization address address: AVENIDA VICENT SOS BAYNAT S/N city: CASTELLON DE LA PLANA postcode: 12006 contact info Titolo: Mr. Nome: Ismael Cognome: Rodrigo-Martinez Email: send email Telefono: +34 964 387480 Fax: +34 964 387625	ES (CASTELLON DE LA PLANA)	participant	50˙400.00

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 Obiettivo del progetto (Objective)

'With a life-time prevalence of 25%, anxiety disorders are the most frequent psychiatric disorders and alone accounted for 147 billion Euros EU health care costs in 2004. The aim of this Marie Curie collaborative research project is to combine and share scientific expertise and shed more light on the dysfunctional neurocircuitry of anxiety disorders. Our current understanding has largely benefited from research on fear and fear learning. Indeed, it has been proposed that disturbed prefrontal cortex (PFC) functions as consequence upon a hyperresponsive amygdala (bottom-up) or/and a lack of PFC-amygdala top-down control are main reasons for affective disorders. In the present project we plan to further identify and disentangle underlying structures and temporal dynamics of both mechanisms using the integration of peripheral and central psychophysiological measures that allow for a millisecond resolution. Firstly, we will concentrate on the role of the PFC in early sensory processing of fear-relevant stimuli using an implicit fear learning paradigm. We propose that the PFC does not only play a part in late, but also in very early modulation of the neuronal fear response. Secondly, we will study how contingency awareness influences the strength of the CS-UCS association in fear conditioning. Using an explicit learning paradigm, both psychophysiological and neuronal correlates of fear learning will be investigated. At last, we will explore the biological basis of extinction learning and reappraisal, two approaches that play a major role in cognitive-behavioral therapy of anxiety disorders. We will study correlates of these processes in implicit and explicit learning tasks in order to study short- and long-term effects of therapeutic interventions. The basic hypothesis is that apart from an impaired top-down control also alterations in bottom-up affective regulation are important for the pathogenesis of anxiety disorders and a successful therapy thereof.'

Introduzione (Teaser)

Neuroscientists have gained new insights into the biological and psychological bases of anxiety.