COATIM

Development of antibiofilm coatings for implants

Coordinatore	KATHOLIEKE UNIVERSITEIT LEUVEN    more  Organization address address: Oude Markt 13 city: LEUVEN postcode: 3000 contact info Titolo: Dr. Nome: Myriam Cognome: Witvrouw Email: send email Telefono: +32 16 32 06 23 Fax: +32 16 32 65 15
Nazionalità Coordinatore	Belgium [BE]
Totale costo	3˙888˙343 €
EC contributo	2˙999˙935 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2011-two-stage
Funding Scheme	CP-FP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-01-01   -   2015-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	KATHOLIEKE UNIVERSITEIT LEUVEN  Organization address address: Oude Markt 13 city: LEUVEN postcode: 3000 contact info Titolo: Dr. Nome: Myriam Cognome: Witvrouw Email: send email Telefono: +32 16 32 06 23 Fax: +32 16 32 65 15	BE (LEUVEN)	coordinator	1˙314˙442.94
2	ALHENIA AG  Organization address city: DAETTWIL postcode: 5405 contact info Titolo: Ms. Nome: Jasminka Cognome: Kovac Email: send email Telefono: +41 56 6220133	CH (DAETTWIL)	participant	339˙750.00
3	EDUCELL PODJETJE ZA CELICNO BIOLOGI JO DOO  Organization address address: Letaliska city: LJUBLJANA postcode: 1000 contact info Titolo: Ms. Nome: Anja Cognome: Planina Email: send email Telefono: +386 5 9077860 Fax: +386 590 77 864	SI (LJUBLJANA)	participant	300˙614.00
4	HEMOTEQ AG  Organization address address: ADENAUERSTRASSE 15 city: WURSELEN postcode: 52146 contact info Titolo: Mr. Nome: Thomas Cognome: Löwen Email: send email Telefono: +49 2405 45500 Fax: +49 2405 4550155	DE (WURSELEN)	participant	274˙774.00
5	UNIVERSITY OF LEEDS  Organization address address: WOODHOUSE LANE city: LEEDS postcode: LS2 9JT contact info Titolo: Mr. Nome: Martin Cognome: Hamilton Email: send email Telefono: +44 113 343 4090 Fax: +44 113 343 4058	UK (LEEDS)	participant	250˙000.00
6	VIB  Organization address address: Rijvisschestraat 120 city: ZWIJNAARDE - GENT postcode: 9052 contact info Titolo: Mr. Nome: Rik Cognome: Audenaert Email: send email Telefono: +32 9 244 66 11 Fax: +32 9 244 66 10	BE (ZWIJNAARDE - GENT)	participant	249˙995.00
7	SIK - INSTITUTET FOER LIVSMEDEL OCH BIOTEKNIK AB  Organization address address: Frans Perssons Vaeg 6 city: GOETEBORG postcode: 40229 contact info Titolo: Prof. Nome: Maud Cognome: Langton Email: send email Telefono: 46105166694	SE (GOETEBORG)	participant	150˙000.00
8	BIOTECH INTERNATIONAL  Organization address address: ALLEES DE CRAPONNE 305 city: SALON DE PROVENCE postcode: 13300 contact info Titolo: Mr. Nome: Frederic Cognome: Impellizzeri Email: send email Telefono: +33 4 90 44 04 55 Fax: 33490446061	FR (SALON DE PROVENCE)	participant	58˙709.25
9	UNIVERZA V LJUBLJANI  Organization address address: KONGRESNI TRG 12 city: LJUBLJANA postcode: 1000 contact info Titolo: Prof. Nome: Gregor Cognome: Majdic Email: send email Telefono: +386 1 4779210 Fax: +386 1 2832243	SI (LJUBLJANA)	participant	55˙000.00
10	BIOFILM CONTROL SAS  Organization address address: BIOPOLE CLERMONT LIMAGNE city: SAINT-BEAUZIRE postcode: 63360 contact info Titolo: Dr. Nome: Thierry Cognome: Bernardi Email: send email Telefono: 33473333980 Fax: 33473670512	FR (SAINT-BEAUZIRE)	participant	6˙650.08
11	SP SVERIGES TEKNISKA FORSKNINGSINSTITUT AB  Organization address address: BRINELLGATAN 4 city: BORAS postcode: 501 15 contact info Titolo: Mrs. Nome: Karin Cognome: Ottosson Email: send email Telefono: +46 10 516 5838	SE (BORAS)	participant	0.00

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 Obiettivo del progetto (Objective)

'The aim of the SME-driven COATIM consortium is to tackle the increasing problem of infections due to biofilms, groups of microorganisms that stick together on different surfaces within the human body and escape conventional antibiotic treatment. Biofilms are typically found on medical devices like implants. The most recent generation of implants with open porosity enable fast osseointegration, but also present an increased risk of microbial biofilm-associated infection. Biofilm-associated infections are responsible for 15-25% of implant failure, and necessitate burdensome and costly revision surgery. The latter is estimated to represent a supplementary medical cost of €800m/year in Europe without taking into account the pain and distress of the patients, indicating that any significant reduction of this type of implant failure is highly recommended. Until now, biocidal implant coatings have been developed that are based on either the release of silver ions, which are toxic upon accumulation, or on conventional antibiotics that have poor activity against microorganisms in biofilms. Therefore, COATIM aims to develop the next generation of implant coatings containing novel potent proprietary antibiofilm molecules (ABMs) with inhibitory activity against microbial biofilms. In COATIM, these ABMs are grafted or deposited on small titanium implant substrates, as a model for dental and orthopaedic implants. Next, the ABM-coated implants are evaluated for in vitro and in vivo activity in resisting microbial infection without compromising osseointegration. Finally, the ABM-coating is applied on complex orthopaedic and dental implants, allowing the exploitation of the results by industry. In parallel, the antibiofilm mode of action of the ABMs is unraveled. COATIM contributes to a dynamic and competitive knowledge-based economy, sustainable development, and serves the needs of the SME-intensive medical technology products market in Europe.'