NATURIMMUN

Natural Killer Cell-Based Anti-Cancer Immunotherapies: Research training in molecular medicine and biotechnology business

Coordinatore	MEDIZINISCHE HOCHSCHULE HANNOVER    more  Organization address address: Carl-Neuberg-Strasse 1 city: HANNOVER postcode: 30625 contact info Titolo: Dr. Nome: Simone Cognome: Hess Email: send email Telefono: +49 511 532 6061
Nazionalità Coordinatore	Germany [DE]
Totale costo	3˙526˙286 €
EC contributo	3˙526˙286 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-ITN
Funding Scheme	MC-ITN
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-10-01   -   2016-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MEDIZINISCHE HOCHSCHULE HANNOVER  Organization address address: Carl-Neuberg-Strasse 1 city: HANNOVER postcode: 30625 contact info Titolo: Dr. Nome: Simone Cognome: Hess Email: send email Telefono: +49 511 532 6061	DE (HANNOVER)	coordinator	450˙214.75
2	MEDIZINISCHE UNIVERSITAET WIEN  Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 contact info Titolo: Prof. Nome: Arndt Cognome: Von Haeseler Email: send email Telefono: +43 1 4277 24007 Fax: +43 1 4277 24098	AT (WIEN)	participant	889˙734.10
3	INSTITUT PASTEUR  Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 contact info Titolo: Dr. Nome: Marie-Laure Cognome: Rosso Email: send email Telefono: +33 145689526	FR (PARIS CEDEX 15)	participant	515˙197.30
4	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Renata Cognome: Schaeffer Email: send email Telefono: +44 1223 333543 Fax: +44 1223 332988	UK (CAMBRIDGE)	participant	285˙056.62
5	UNIVERSITY COLLEGE LONDON  Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT contact info Titolo: Ms. Nome: Malgorzata Cognome: Kielbasa Email: send email Telefono: 442031000000	UK (LONDON)	participant	285˙056.62
6	IPD-THERAPEUTICS BV  Organization address address: ONDERWIJSBOULEVARD 219 city: 'S HERTOGENBOSCH postcode: 5203 DB contact info Titolo: Dr. Nome: Wim Cognome: Jongen Email: send email Telefono: +31 412 211 001	NL ('S HERTOGENBOSCH)	participant	236˙861.45
7	UNIVERSIDAD POMPEU FABRA  Organization address address: PLACA DE LA MERCE 10-12 city: BARCELONA postcode: 8002 contact info Titolo: Dr. Nome: Miguel Cognome: López Botet Email: send email Telefono: +34 93 316 0780 Fax: +34 93 316 1901	ES (BARCELONA)	participant	226˙681.62
8	THE HEBREW UNIVERSITY OF JERUSALEM.  Organization address address: GIVAT RAM CAMPUS city: JERUSALEM postcode: 91904 contact info Titolo: Ms. Nome: Jane Cognome: Turner Email: send email Telefono: +972 2 6586676 Fax: +972 7 22447007	IL (JERUSALEM)	participant	224˙613.84
9	MILTENYI BIOTEC GMBH  Organization address address: FRIEDRICH EBERT STRASSE 68 city: BERGISCH GLADBACH postcode: 51429 contact info Titolo: Ms. Nome: Sabrina Cognome: Schmitz Email: send email Telefono: +49 2204 8306 4497	DE (BERGISCH GLADBACH)	participant	222˙068.88
10	AFFIMED THERAPEUTICS AG  Organization address address: IN NEUENHEIMER FELD 582 city: HEIDELBERG postcode: 69120 contact info Titolo: Mrs. Nome: Michaela Cognome: Braun Email: send email Telefono: +49 6221 6530714 Fax: +49 6221 653 0777	DE (HEIDELBERG)	participant	190˙800.72
11	KING'S COLLEGE LONDON  Organization address address: Strand city: LONDON postcode: WC2R 2LS contact info Titolo: Mr. Nome: Paul Cognome: Labbett Email: send email Telefono: 442078000000	UK (LONDON)	participant	0.00

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 Obiettivo del progetto (Objective)

'In the research part we will deal with the basic principles of the innate immune defense used to control tumors and viral infections with a focus on NK and NK/T cells, including analysis of NK receptor genomics/epigenetics, gene polymorphisms/disease linkage, differentiation of hitherto unrecognized NK cell subpopulations and novel ligands for NK receptors exposed by tumor and/or virally infected cells. We will investigate the mechanisms installed by tumors and viruses to avoid or subvert immune defenses. This will include the investigation of the role of NK/T cell subpopulations in the defense against tumors and infections by herpes virus family members, some being involved in tumor formation, in the development of inflammatory diseases and/or constituting a frequent complication during tumor therapy. The project will support anti-tumor and anti-viral therapies by developing novel technology for NK cell generation from cord blood stem cells for NK cell infusions in patients, by genetic engineering of NK cells and by using NK receptors and their ligands to develop novel reagents for amplifying anti-tumor and -viral activities of NK/T cells. It will further undertake basic studies on the potential of the newly emerging iPS cell technology for reconstituting immune systems including NK cells in patients with hematologic cancers. All students of this ITN will be trained in state-of-the-art immunotechnology including wider aspects of molecular medicine at the individual partner universities. An exchange of students between the different partners will be organized to ensure that every participant will be trained in several laboratories/universities with different expertise. It will further include network-wide training modules with cutting-edge lectures of internationally recognized research experts in the field, state-of-the-art seminars in the front-line technologies used in this project as well as courses in genome-wide bioinformatics, business and patent rights.'