SMARTCANCERSENS

Micro/nanosensors for early cancer warning system - diagnostic and prognostic information

Coordinatore	INSTITUTE OF TECHNOLOGY TALLAGHT    more  Organization address address: OLD BLESSINGTON ROAD city: TALLAGHT DUBLIN 24 postcode: 24 contact info Titolo: Prof. Nome: Eithne Cognome: Dempsey Email: send email Telefono: +353 1 4042862
Nazionalità Coordinatore	Ireland [IE]
Totale costo	584˙800 €
EC contributo	584˙800 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-IRSES
Funding Scheme	MC-IRSES
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-01-01   -   2016-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUTE OF TECHNOLOGY TALLAGHT  Organization address address: OLD BLESSINGTON ROAD city: TALLAGHT DUBLIN 24 postcode: 24 contact info Titolo: Prof. Nome: Eithne Cognome: Dempsey Email: send email Telefono: +353 1 4042862	IE (TALLAGHT DUBLIN 24)	coordinator	85˙800.00
2	UNIVERSITATEA DIN BUCURESTI  Organization address address: MIHAIL KOGALNICEANU STREET 36-46 SECTOR V city: BUCURESTI postcode: 50107 contact info Titolo: Prof. Nome: Camelia Cognome: Bala Email: send email Telefono: 40214104888 Fax: 40214104888	RO (BUCURESTI)	participant	117˙000.00
3	LINKOPINGS UNIVERSITET  Organization address address: CAMPUS VALLA city: LINKOPING postcode: 581 83 contact info Titolo: Prof. Nome: Anthony P.F. Cognome: Turner Email: send email Telefono: +46 013282604	SE (LINKOPING)	participant	108˙400.00
4	UNIVERSITE LYON 1 CLAUDE BERNARD  Organization address address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43 city: VILLEURBANNE CEDEX postcode: 69622 contact info Titolo: Dr. Nome: Javier Cognome: Olaiz Email: send email Telefono: 33472697600 Fax: 33472697609	FR (VILLEURBANNE CEDEX)	participant	98˙900.00
5	UNIVERSIDADE DE COIMBRA  Organization address address: PACO DAS ESCOLAS city: COIMBRA postcode: 3001 451 contact info Titolo: Mr. Nome: Sergio Cognome: Vicente Email: send email Telefono: +351 239 247 750	PT (COIMBRA)	participant	87˙700.00
6	UNIVERSITAT ROVIRA I VIRGILI  Organization address address: CARRER DE ESCORXADOR city: TARRAGONA postcode: 43003 contact info Titolo: Dr. Nome: Rosa Cognome: Solà I Alberich Email: send email Telefono: 34977558002	ES (TARRAGONA)	participant	87˙000.00

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 Obiettivo del progetto (Objective)

'Oncologists still rely heavily on biological characterisation of tumours and a limited number of biomarkers which have demonstrated clinical utility. Routine cancer diagnostic tools may not be always sensitive enough and may only detect proteins at levels corresponding to an advanced stage of the disease. Recently, new genomic and proteomic molecular tools (molecular signatures) are being employed which include genetic and epigenetic signatures, changes in gene expression, protein profiles and post-translational modification of proteins. Such advanced diagnostic tools are not always readily adapted to clinical cancer screening due to their complexity, costs and the requirement for highly-qualified operators. Novel bioanalytical methodologies for detection of specific biomarkers/ biomolecules, based on nanostructured electronic sensors (rapid, sensitive devices capable of miniaturisation and deployment on site or in small clinics), fulfill the necessary requirements and have the potential to compliment time- and labour consuming clinical analysers used in medical laboratories currently. The primary objective of this proposal, therefore, is to gather together an international and interdisciplinary consortium of ten research teams from EU Member States, Third (including ENP) countries with EU agreements on S&T, in order to share and jointly exploit knowledge and expertise in the development of micro/nanosensors as tools in early cancer diagnosis. A key scientific target is the realisation of intelligent electronic devices which respond to biomolecules such as formaldehyde, amines, metal ions, saccharides, activities of amine oxidases, arginase and glutathione-S-transferase. This will entail design, development and characterisation of nano-scale transducers suitable for testing in clinical samples.'