THERAGLIO

Microbubble driven multimodal imaging and theranostics for gliomas

Coordinatore	FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA    more  Organization address address: VIA CELORIA 11 city: MILANO postcode: 20133 contact info Titolo: Dr. Nome: Francesca Cognome: Grechi Email: send email Telefono: +39 0223942320
Nazionalità Coordinatore	Italy [IT]
Totale costo	10˙283˙796 €
EC contributo	5˙998˙890 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2013-INNOVATION-1
Funding Scheme	CP-FP
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-10-01   -   2018-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA  Organization address address: VIA CELORIA 11 city: MILANO postcode: 20133 contact info Titolo: Dr. Nome: Francesca Cognome: Grechi Email: send email Telefono: +39 0223942320	IT (MILANO)	coordinator	1˙315˙728.00
2	THE FOUNDATION FOR MEDICAL RESEARCHINFRASTRUCTURAL DEVELOPMENT AND HEALTH SERVICES NEXT TO THE MEDICAL CENTER TEL AVIV  Organization address address: WEIZMANN STREET 6 city: Tel Aviv postcode: 64239 contact info Titolo: Prof. Nome: Zvi Cognome: Ram Email: send email Telefono: +972 36974273 Fax: +972 36974860	IL (Tel Aviv)	participant	1˙007˙354.00
3	UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA  Organization address address: VIA ORAZIO RAIMONDO 18 city: ROMA postcode: 173 contact info Titolo: Prof. Nome: Gaio Cognome: Paradossi Email: send email Telefono: +39 0672594464 Fax: +39 0672594327	IT (ROMA)	participant	864˙150.00
4	MEDCOM GESELLSCHAFT FUER MEDIZINISCHE BILDVERARBEITUNG MBH  Organization address address: RUNDETURMSTRASSE 12 city: DARMSTADT postcode: 64283 contact info Titolo: Ms. Nome: Tamara Cognome: Dannenmann Email: send email Telefono: +49 6151 95147 21 Fax: +49 6151 95147 20	DE (DARMSTADT)	participant	630˙500.00
5	SEROSCIENCE KUTATO FEJLESZTO ES KERESKEDELMI KORLATOLT FELELOSSEGU TARSASAG  Organization address address: LORANT UTCA 10 B EP FSZT 2 city: BUDAPEST postcode: 1125 contact info Titolo: Mr. Nome: János Cognome: Csukás Email: send email Telefono: 36306396476	HU (BUDAPEST)	participant	478˙900.00
6	PRAXIS BIOPHARMA RESEARCH INSTITUTE SL  Organization address address: CALLE HERMANOS LUMIERE 5 city: Vitoria-Gasteiz postcode: 1510 contact info Titolo: Dr. Nome: Silvia Cognome: Villullas Email: send email Telefono: +34 945298198 Fax: +34 945298085	ES (Vitoria-Gasteiz)	participant	474˙301.00
7	CAMELOT BIOMEDICAL SYSTEMS SRL  Organization address address: VIA GRETO DI CORNIGLIANO 6R city: GENOVA postcode: 16152 contact info Titolo: Dr. Nome: Matteo Cognome: Santoro Email: send email Telefono: +39 3200772584 Fax: +39 0108695742	IT (GENOVA)	participant	452˙840.00
8	ESAOTE SPA  Organization address address: VIALE BIANCA MARIA 25 city: MILANO postcode: 20122 contact info Titolo: Dr. Nome: Sergio Cognome: Paddeu Email: send email Telefono: +39 0106547483 Fax: +39 0106547433	IT (MILANO)	participant	368˙750.00
9	NANOMOL TECHNOLOGIES SA  Organization address address: LG EDIFICI EUREKA.CAMPUS UAB BELLATERRA city: CERDANYOLA DEL VALLES postcode: 8193 contact info Titolo: Dr. Nome: Santiago Cognome: Sala Email: send email Telefono: +34 935868963	ES (CERDANYOLA DEL VALLES)	participant	280˙574.00
10	CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL  Organization address address: Via Giuseppe Mussi 1 city: MILANO postcode: 20154 contact info Titolo: Ms. Nome: Carla Cognome: Finocchiaro Email: send email Telefono: +39 023108331 Fax: +39 0233614064	IT (MILANO)	participant	125˙793.00
11	MAGFORCE AG  Organization address address: MAX-PLANCK-STRASSE 3 city: BERLIN postcode: 12489 contact info Titolo: Dr. Nome: Stefan Cognome: Gerbes Email: send email Telefono: +49 30 308 380 91	DE (BERLIN)	participant	0.00

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 Obiettivo del progetto (Objective)

'Microbubbles (MBs) are used as contrast agent in ultrasound (US) imaging for a variety of tumours while little has been done for glioblastomas, a rare cancer. Intraoperative Contrast-Enhanced US-imaging (CEUS) using lipidic MBs hold promises in increasing extent of resection of such tumors. Furthermore, MBs gained recently interest as a delivery system for drugs. We will develop a new generation of multimodal MBs, acting simultaneously as contrast agent for Magnetic Resonance Imaging (MRI), CEUS and intra-operative fluorescence for multimodal real-time image-guided resection of glioblastomas. We plan to transform MBs by replacing air with perfluorcarbon gas and/or attaching super-paramagnetic-iron-oxide nanoparticles for MRI visualization. We will also engineer MBs with RGD-motif to adhere selectively to pathological endothelial integrins and with near-infrared fluorophores for simultaneous US deep tissue imaging and direct microscopic tumour visualization to maximize resection. A software will be developed for integration of preoperative MRI, intraoperative US and microscopic imaging. We will focus on lipidic and polymeric MBs. Lipidic MBs are approved for clinical use; therefore, once modified, more easily translatable into clinical applications to reach a feasibility study on patients. In addition, we will improve multifunctional, polymer-based MBs. Multifunctional-stabilized-polymer-MBs are more stable and more versatile to be complexed with different molecules or nanoparticles as compared to lipidic Mbs and will be designed as a platform for delivering standard and/or experimental chemotherapeutic drugs to the tumour, acting as an innovative way for local targeting and delivering any kind of agent to a specific target, in a safe and controlled fashion. This would be a big step forward in the field of personalized medicine, moving standard MG image-guided treatment towards more effective, safer, molecular-based tailored interventions to specific patients.'