PSYCHGENE

Copy Number Variation and Endophenotypes in Psychiatric Disorders

Coordinatore	ISLENSK ERFDAGREINING EHF    more  Organization address address: Sturlugata 8 city: REYKJAVIK postcode: 101 contact info Titolo: Mr. Nome: Bjorgvin Cognome: Richardsson Email: send email Telefono: +354 570 1900 Fax: +354 570 1981
Nazionalità Coordinatore	Iceland [IS]
Totale costo	652˙085 €
EC contributo	652˙085 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-3-1-IAPP
Funding Scheme	MC-IAPP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-03-01   -   2012-02-29

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ISLENSK ERFDAGREINING EHF  Organization address address: Sturlugata 8 city: REYKJAVIK postcode: 101 contact info Titolo: Mr. Nome: Bjorgvin Cognome: Richardsson Email: send email Telefono: +354 570 1900 Fax: +354 570 1981	IS (REYKJAVIK)	coordinator	0.00
2	DANMARKS TEKNISKE UNIVERSITET  Organization address address: Anker Engelundsvej 1, Building 101A city: KONGENS LYNGBY postcode: 2800 contact info Titolo: Ms. Nome: Karen Cognome: Bue Bitsch Email: send email Telefono: +45 45 25 7520 Fax: +45 45 88 4922	DK (KONGENS LYNGBY)	participant	0.00
3	Sct. Hans Hospital-Forskninginstitut for Biologisk Psykiatri  Organization address address: Boserupvej 2 city: Roskilde postcode: 4000 contact info Titolo: Dr. Nome: Thomas Cognome: Werge Email: send email Telefono: 4546334968 Fax: 4546334367	DK (Roskilde)	participant	0.00

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 Obiettivo del progetto (Objective)

'A genome-wide copy number variant (CNV) association study for schizophrenia (SZ), bipolar disorder (BP) and major depression (MD) will be conducted at deCODE genetics using a discovery sample of 2400 affected (800 SZ, 600 BP, 1,000 MD) and 20,000 controls. CNV data will be generated from the newly released HumanCNV370-Duo array designed by deCODE genetics and Illumina. In this array there are about 55,000 probes covering known and supsected CNV regions. Algorithms for data analysis are being developed at deCODE. Employees from the Research Institute of Biological Psychiatry (RIBP) of Copenhagen University Hospital and Center for Biological Sequence analysis (CBS) at Denmarks Technical University will work with deCODE on analyzing the data. CNVs associating with SZ, BP and MD in Iceland will be tested in SZ (n=800), BP (n=600) and MD (n=600) and control samples from RIBP using TaqMan probes to measure gene dosage. The confirmation and subsequent functional analysis, including gene expression, will be carried out at deCODE. Scientists from RIBP and CBS will test disease-specific candidate genes, derived from biological networks, for association to SZ, BP and MD in the Icelandic samples and confirm the findings in the RIBP samples. These methods, reduce the correction factor for false positive findings, as only a small subset of polymorphisms (SNPs and CNVs) will be investigated. This allows identification of susceptibility variants conferring low risk. Variants, associating with SZ, BP and MD in the follow-up samples, will be studied further by analyzing endophenotypes, i.e. treatment response, severity, etc. in the RIBPsamples. This will implement data stored in the Danish Psychiatric Biobank maintained at RIBP. Scientists from deCODE will work with scientists from RIBP on analyzing the endophenotypic data. Furthermore samples and phenotypic data from first degree relatives of SZ, BP and MD patients will be collected, analyzed and genotyped for CNVs and SNPs.'