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The role of mRNA-processing bodies in ageing

 Coordinatore "BIOMEDICAL RESEARCH FOUNDATION, ACADEMY OF ATHENS" 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Greece [EL]
 Totale costo 1˙080˙000 €
 EC contributo 1˙080˙000 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2007-StG
 Funding Scheme ERC-SG
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-09-01   -   2014-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    "BIOMEDICAL RESEARCH FOUNDATION, ACADEMY OF ATHENS"

 Organization address address: Soranou Efesiou 4
city: ATHENS
postcode: 11527

contact info
Titolo: Dr.
Nome: Popi
Cognome: Syntichaki
Email: send email
Telefono: -6942872514

EL (ATHENS) hostInstitution 0.00
2    "BIOMEDICAL RESEARCH FOUNDATION, ACADEMY OF ATHENS"

 Organization address address: Soranou Efesiou 4
city: ATHENS
postcode: 11527

contact info
Titolo: Mr.
Nome: Dimitris
Cognome: Raptis
Email: send email
Telefono: +30 210 6597574
Fax: +30 210 6597571

EL (ATHENS) hostInstitution 0.00

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direct       resistance    elegans    mrna    lifespan    alterations    stress    profile    metabolism    related    lived    ageing    expression    granules    particle    genes    bodies    cells    age    worms    encoding    wild   

 Obiettivo del progetto (Objective)

'Recently, we and others have revealed that, in the nematode Caenorhabditis elegans, reduction of protein synthesis rates in somatic cells extends lifespan. Based on this, we postulate that the molecular factors and mechanisms that control the mRNA metabolism in post-mitotic cells are critical determinants of ageing. This project will validate this hypothesis using C. elegans as main model system, but parallel studies in Saccharomyces cerevisiae and Drosophila melanogaster will prove the conservation of our observations. The cellular factors involved in mRNA metabolism (degradation/storage) are localized at specific particles in the cytoplasm of all eukaryotic cells, termed mRNA processing (P) bodies. Additionally, stress granules are cytoplasmic sites of mRNA-metabolism that are formed under stress conditions in mammalian cells. The objectives of this project include: -Monitoring of both P bodies and stress granules in adult worms and characterization of the age-related alterations in their profile, by immunostaining and real-time fluorescence imaging -Direct alterations in the expression of genes encoding factors of each particle in wild-type worms and analysis of the effects on lifespan and stress resistance -Comparison of the age-related changes in the profile of P bodies and stress granules between wild-type and long- or short-lived mutant worms -Direct alterations in the expression of genes encoding factors of each particle in worms with altered lifespan and investigation of the effects on lifespan and stress resistance -Observation of the age-related alterations in the profile of P bodies in yeast and flies, both in wild-type and long-lived strains. The rationale for this project is to provide insight into the modulation of ageing and stress resistance at the level of mRNA metabolism, which is a yet unexplored field of the biology of ageing and global stress response.'

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