SUPERCOMPETITORS

GENETIC AND GENOMIC STUDY OF CELL COMPETITION IN DROSOPHILA

 Coordinatore UNIVERSITAET BERN 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 970˙100 €
 EC contributo 970˙100 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2007-StG
 Funding Scheme ERC-SG
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-09-01   -   2013-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

 Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3
city: MADRID
postcode: 28029

contact info
Titolo: Ms.
Nome: Laura
Cognome: Bertolini
Email: send email
Telefono: +34 917 328 000
Fax: +34 912 246 980

ES (MADRID) beneficiary 0.00
2    UNIVERSITAET BERN

 Organization address address: Hochschulstrasse 4
city: BERN
postcode: 3012

contact info
Titolo: Dr.
Nome: Eduardo
Cognome: Moreno
Email: send email
Telefono: +41 3 16314615
Fax: +41 3 16314616

CH (BERN) hostInstitution 0.00
3    UNIVERSITAET BERN

 Organization address address: Hochschulstrasse 4
city: BERN
postcode: 3012

contact info
Titolo: Ms.
Nome: Maddalena
Cognome: Tognola
Email: send email
Telefono: +41 31 631 48 09
Fax: +41 31 631 51 06

CH (BERN) hostInstitution 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

microarrays    normal    cells    drosophila    cancer    cell    stages    tumor    competition    competitive    genes    vitro    human   

 Obiettivo del progetto (Objective)

'During initial stages a cell accumulating tumor-promoting mutations is usually surrounded by normal cells. Current cancer models do not incorporate this transition from a single cell to a field of cells, although it is probably critical, since the behavior of an individual tumor cell within the cell community has to be dictated by the hard-wired genetic program that controls its aberrant cell biology and modulated by the plastic interactions with neighboring normal cells. Study of model organisms, such as yeast, C. elegans, or Drosophila, has historically pioneered crucial contributions to processes with important implications in neoplasia. Recent work in Drosophila has proposed a role for cell-competition and super-competition in early stages of cancer formation. Cell competition is a type of cell-cell interaction in which more competitive cells replace less competitive cells (Morata and Ripoll, 1975; Moreno et al. 2002). During the last year, my laboratory has performed the first microarrays to find genes involved in cell competition, as well as developed an in vitro system for cell competition. The genes identified in the microarrays are not downstream dMyc but are rather induced at the boundaries where cell competition takes place and seem to be upstream apoptosis induction. The new genes will be studied in vivo in Drosophila and in vitro with RNAi. We will also perform other microarray settings to subdivide the genes in different categories. Thanks to the complete genome sequences of both Drosophila and humans, those genes could be used to find human homologues that could serve as novel markers and targets for the detection and/or treatment of cancer at earlier stages. The possible use of cell competition as a tool for cell replacement will also be pursued. We expect to patent at least two or three of the novel uncharacterized genes with human homologs.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

SELFCHEM (2010)

Information Transfer through Self-organization Processes in Systems Chemistry

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ANGLE (2012)

Accelerated design and discovery of novel molecular materials via global lattice energy minimisation

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PROSPER (2011)

Design of polymer optical fibre gratings for endoscopic biosensing purposes

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