NEUROGLIA
Molecular and cellular investigation of neuron-astroglia interactions: Understanding brain function and dysfunction
| Coordinatore | UNIVERSITAETSKLINIKUM BONN
Organization address
address: Sigmund-Freud-Strasse 25 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Sito del progetto | http://www.neuroglia.eu/welcome.php |
| Totale costo | 3˙917˙986 € |
| EC contributo | 2˙988˙450 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2007-A |
| Funding Scheme | CP-FP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-01-01 - 2012-06-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITAETSKLINIKUM BONN
Organization address
address: Sigmund-Freud-Strasse 25 contact info |
DE (BONN) | coordinator | 0.00 |
| 2 |
Academisch Medisch Centrum bij de Universiteit van Amsterdam
Organization address
address: MEIBERGDREEF 9 contact info |
NL (AMSTERDAM) | participant | 0.00 |
| 3 |
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Organization address
address: CALLE SERRANO 117 contact info |
ES (MADRID) | participant | 0.00 |
| 4 |
CARDIFF UNIVERSITY
Organization address
address: Newport Road 30-36 contact info |
UK (CARDIFF) | participant | 0.00 |
| 5 |
CONSIGLIO NAZIONALE DELLE RICERCHE
Organization address
address: Piazzale Aldo Moro 7 contact info |
IT (ROMA) | participant | 0.00 |
| 6 |
EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Organization address
address: Science Park 1, Stuhlsatzenhausweg 69 contact info |
DE (SAARBRUECKEN) | participant | 0.00 |
| 7 |
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Organization address
address: Hofgartenstrasse 8 contact info |
DE (MUENCHEN) | participant | 0.00 |
| 8 |
UNIVERSITAET DES SAARLANDES
Organization address
address: CAMPUS contact info |
DE (SAARBRUECKEN) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Astroglial cells are now recognized as active elements in the brain that sense and integrate synaptic signals and, by releasing gliotransmitters, regulate synaptic efficacy and cerebral blood flow. Despite accrued knowledge, many fundamental aspects of neuron-astroglia partnerships remain open, or have been poorly addressed in a functional context in vivo. For example, does astroglia heterogeneity reflect distinct functions? How do astroglial and neuronal networks interact locally and temporally? How does disruption of neuron-glia interactions contribute to brain disorders? Leading European research groups in the field have gathered in NeuroGLIA to address such questions using a multi-disciplinary approach, including transgenic astroglia-subtype specific mice, electrophysiology and high resolution laser scanning microscopy in vitro and in vivo (including awake mice). This will enable the consortium: i) to verify the potential of activated astroglia to signal back to neurons rapidly; ii) to define the spatial-temporal dynamics of neuron–astroglia reciprocal signalling; iii) to clarify the specific function of different astroglial subtypes in modulation of neuronal excitability and transmission, and in the control of neurovascular coupling. NeuroGLIA will also investigate how dysfunction of neuron-astroglia signalling contributes to the pathogenesis of brain disorders, focussing on epilepsy. In animal models of epilepsy, astroglial activity will be analyzed with respect to initiation, maintenance and cessation of epileptiform activity, also in relation to blood flow changes and activation of inflammatory pathways. Importantly, access to living tissue from epilepsy patients, allows NeuroGLIA to investigate neuron-astroglia interactions and its dysregulation in the human brain. NeuroGLIA is thus in the privileged position to unravel fundamental mechanisms of neuron-astroglia signalling in health and disease, opening new perspectives for specific therapeutic strategies.'