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EPoS SIGNED

Elucidating Pathways of Steatohepatitis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EPoS project word cloud

Explore the words cloud of the EPoS project. It provides you a very rough idea of what is the project "EPoS" about.

promises translation hinder biopsy healing procedure environmental multiple transplants population patient drivers risk alcohol definitive disease diagnosis aging acceptable mellitus consumption pathologies perturbed understand single cancer absence 2020 once lipid epidemics epos strongly inflammation cirrhosis accumulation atlas dimensional plus cohort hepatic aetiology steatohepatitis 30 sits stratification hepatocellular morbidity nafld fatty spectrum therapy invasive care wound risky nash carcinoma diabetes entire record closely medical cardiovascular immune patients healthcare determines steatosis fat drive fibrosis substantial biological inter biology variation pathogenic carbohydrate pathophysiological benefit costly unknown activation severity worldwide intersection omics alcoholic obesity variability progression t2dm treatment rate inflammatory progressive liver homeostasis underlying

Project "EPoS" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF NEWCASTLE UPON TYNE Organization address address: KINGS GATE city: NEWCASTLE UPON TYNE postcode: NE1 7RU website: http://www.ncl.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.epos-nafld.eu
Total cost	6˙173˙021 €
EC max contribution	5˙985˙521 € (97%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2019-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF NEWCASTLE UPON TYNE UNIVERSITY OF NEWCASTLE UPON TYNE Organization address address: KINGS GATE city: NEWCASTLE UPON TYNE postcode: NE1 7RU website: http://www.ncl.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NEWCASTLE UPON TYNE)	coordinator	1˙629˙948.00
2	INST CARDIOMETABOLISME NUTRITION ICAN INST CARDIOMETABOLISME NUTRITION ICAN Organization address address: BOULEVARD DE L'HOPITAL 47-83 city: PARIS postcode: 75013 website: www.ican-institute.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	1˙012˙317.00
3	UNIVERSITA DEGLI STUDI DI TORINO UNIVERSITA DEGLI STUDI DI TORINO Organization address address: VIA GIUSEPPE VERDI 8 city: TORINO postcode: 10124 website: www.unito.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	participant	662˙635.00
4	OREBRO UNIVERSITY OREBRO UNIVERSITY Organization address address: FAKULTETSGATAN 1 city: OREBRO postcode: 70182 website: www.oru.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (OREBRO)	participant	568˙059.00
5	CONSIGLIO NAZIONALE DELLE RICERCHE CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	533˙065.00
6	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	517˙990.00
7	IXSCIENT LIMITED IXSCIENT LIMITED Organization address address: POPES GROVE 76 city: TWICKENHAM MIDDLESEX postcode: TW1 4JX website: www.ixscient.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (TWICKENHAM MIDDLESEX)	participant	298˙750.00
8	UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ Organization address address: Langenbeckstrasse 1 city: Mainz postcode: 55131 website: http://www.um-mainz.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Mainz)	participant	261˙000.00
9	NORDIC BIOSCIENCE A/S NORDIC BIOSCIENCE A/S Organization address address: HERLEV HOVEDGADE 205-207 city: HERLEV postcode: 2730 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HERLEV)	participant	187˙500.00
10	NOVO NORDISK INVEST 4 A/S NOVO NORDISK INVEST 4 A/S Organization address address: NOVO ALLE 1 city: BAGSVAERD postcode: 2880 website: www.steno.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (BAGSVAERD)	participant	184˙256.00
11	HELSINGIN YLIOPISTO HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINGIN YLIOPISTO)	participant	130˙000.00
12	NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S Organization address address: Herlev Hovedgade 207 city: Helev postcode: 2730 website: www.nordicbioscience.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (Helev)	participant	0.00

Map

Project objective

Strongly associated with the epidemics of obesity and type 2 diabetes mellitus (T2DM) that are testing healthcare systems worldwide, Non-Alcoholic Fatty Liver Disease (NAFLD) is an increasingly common cause of advanced liver disease in the aging population of Europe. NAFLD is a spectrum of hepatic fat accumulation (steatosis); steatosis plus inflammation (non-alcoholic steatohepatitis, NASH); fibrosis/cirrhosis; and hepatocellular carcinoma in the absence of high alcohol consumption. Up to 30% of the EU population have NAFLD, which will be the main aetiology underlying liver transplants by 2020. However, NAFLD is characterized by substantial inter-patient variability in severity and rate of progression. What determines this is unknown. A large population is at risk, but only some experience morbidity. NAFLD severity is currently best assessed by liver biopsy, an invasive, costly and risky procedure - factors that hinder treatment. There is a need to understand the biological and environmental factors that drive inter-patient variability and to develop robust and more acceptable methods for diagnosis, risk stratification and therapy so that effective medical care may be targeted to those that will benefit most. The overall EPoS concept is that improved understanding of pathogenic processes and drivers of disease progression will best be achieved when multiple ‘omics’ approaches are applied to a single cohort of patients to build a multi-dimensional record of how systems are perturbed across the entire spectrum of disease. NAFLD sits at the intersection of key biological processes: carbohydrate/lipid homeostasis, immune/inflammatory activation, wound healing/fibrosis and cancer biology. Once completed, EPoS promises to deliver a substantial and definitive atlas of pathophysiological variation across a spectrum of progressive liver disease. Translation of these findings will therefore impact on closely related pathologies including T2DM and cardiovascular disease.

Deliverables

List of deliverables.
Final reports summarising recruitment into the EPoS database, biobanked samples availability, and longitudinal outcome studies	Documents, reports	2020-02-12 18:04:46
Risk assessment procedure	Documents, reports	2019-12-17 15:24:27
Report on data management plan for the EPoS project	Documents, reports	2019-12-17 15:24:27
Project Handbook	Documents, reports	2019-12-17 15:24:27
Detailed dissemination plan	Documents, reports	2019-12-17 15:24:27

Take a look to the deliverables list in detail: detailed list of EPoS deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	Rosso, Chiara; Younes, Ramy; Fabrizia, Carli; Melania, Gaggini; Lavinia, Mezzabotta; Marietti, Milena; Federico, Salomone; Gambino, Roberto; Saba, Francesca; Emma, Buzzigoli; Demetrio, Ciociaro; Caviglia, GIAN PAOLO; Morello, Elisabetta; Abate, Maria Lorena; Smedile, Antonina; Ciancio, Alessia; Cassader, Maurizio; Saracco, Giorgio Maria; Amalia, Gastaldelli; Bugianesi, Elisabetta Plasma Selenoprotein P levels are related to adipose tissue insulin resistance, composition of free fatty acids and liver fibrosis in non-diabetic patients with Non Alcoholic Fatty Liver Disease published pages: , ISSN: , DOI:	9	2020-01-30
2019	Marie Boyle, Dina Tiniakos, Jorn M. Schattenberg, Vlad Ratziu, Elisabetta Bugianessi, Salvatore Petta, Claudia P. Oliveira, Olivier Govaere, Ramy Younes, Stuart McPherson, Pierre Bedossa, Mette J Nielsen, Morten Karsdal, Diana Leeming, Stuart Kendrick, Quentin M. Anstee Performance of the PRO-C3 collagen neo-epitope biomarker in non-alcoholic fatty liver disease published pages: 188-198, ISSN: 2589-5559, DOI: 10.1016/j.jhepr.2019.06.004	JHEP Reports 1/3	2020-01-29
2018	Gemma F. Codner, Joffrey MiannÃ©, Adam Caulder, Jorik Loeffler, Rachel Fell, Ruairidh King, Alasdair J. Allan, Matthew Mackenzie, Fran J. Pike, Christopher V. McCabe, Skevoulla Christou, Sam Joynson, Marie Hutchison, Michelle E. Stewart, Saumya Kumar, Michelle M. Simon, Loranne Agius, Quentin M. Anstee, Kirill E. Volynski, Dimitri M. Kullmann, Sara Wells, Lydia Teboul Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants published pages: , ISSN: 1741-7007, DOI: 10.1186/s12915-018-0530-7	BMC Biology 16/1	2020-01-29
2019	Morten A. Karsdal, Sara T. Hjuler, Yi Luo, Daniel G. K. Rasmussen, Mette J. Nielsen, Signe Holm Nielsen, Diana J. Leeming, Zachary Goodman, Robert H. Arch, Keyur Patel, Detlef Schuppan Assessment of liver fibrosis progression and regression by a serological collagen turnover profile published pages: G25-G31, ISSN: 0193-1857, DOI: 10.1152/ajpgi.00158.2018	American Journal of Physiology-Gastrointestinal and Liver Physiology 316/1	2020-01-29
2019	Fang Wei, Santosh Lamichhane, Matej OreÅ¡iÄ, Tuulia HyÃ¶tylÃ¤inen Lipidomes in health and disease: Analytical strategies and considerations published pages: 115664, ISSN: 0165-9936, DOI: 10.1016/j.trac.2019.115664	TrAC Trends in Analytical Chemistry 120	2020-01-29
2019	Yvonne Huber, Daniel Pfirrmann, Ines Gebhardt, Christian Labenz, Nadine Gehrke, Beate K. Straub, Christian Ruckes, Heike Bantel, Eugenio Belda, Karine ClÃ©ment, Diana J. Leeming, Morten A. Karsdal, Peter R. Galle, Perikles Simon, JÃ¶rn M. Schattenberg Improvement of non-invasive markers of NAFLD from an individualised, web-based exercise program published pages: 930-939, ISSN: 0269-2813, DOI: 10.1111/apt.15427	Alimentary Pharmacology & Therapeutics 50/8	2020-01-29
2015	Hannele Yki-JÃ¤rvinen, Panu K. Luukkonen Heterogeneity of non-alcoholic fatty liver disease published pages: 2498-2500, ISSN: 1478-3223, DOI: 10.1111/liv.12970	Liver International 35/12	2020-01-29
2019	Feng Liu, George Boonâ€Bee Goh, Dina Tiniakos, Aileen Wee, Weiâ€Qiang Leow, Jingâ€Min Zhao, Huiâ€Ying Rao, Xiaoâ€Xiao Wang, Qin Wang, Weiâ€Keat Wan, Kiatâ€Hon Lim, Manuel Romeroâ€Gomez, Salvatore Petta, Elisabetta Bugianesi, Cheeâ€Kiat Tan, Stephen A. Harrison, Quentin M. Anstee, Pikâ€Eu Jason Chang, Lai Wei qFIBS: A Novel Automated Technique for Quantitative Evaluation of Fibrosis, Inflammation, Ballooning, and Steatosis in Patients With Nonalcoholic Steatohepatitis published pages: , ISSN: 0270-9139, DOI: 10.1002/hep.30986	Hepatology	2020-01-29
2018	Emma Scott, Quentin M Anstee Genetics of alcoholic liver disease and non-alcoholic steatohepatitis published pages: s54-s59, ISSN: 1470-2118, DOI: 10.7861/clinmedicine.18-2-s54	Clinical Medicine 18/Suppl 2	2020-01-29
2018	Carli, F.; Gaggini, M.; Rosso, C.; Saponaro, C.; Barbieri, C.; Latta, V. D.; Buzzigoli, E.; Ciociaro, D.; Abate, M. L.; Marietti, M.; Younes, R.; Bugianesi, E.; Gastaldelli, A. In non obese NAFLD increased plasma saturated fatty acids and insulin resistance are metabolic signatures of severity of liver disease published pages: , ISSN: , DOI:	8	2020-01-29
2017	Vlad Ratziu Non-pharmacological interventions in non-alcoholic fatty liver disease patients published pages: 90-96, ISSN: 1478-3223, DOI: 10.1111/liv.13311	Liver International 37	2020-01-29
2019	Ramy Younes, Elisabetta Bugianesi A spotlight on pathogenesis, interactions and novel therapeutic options in NAFLD published pages: 80-82, ISSN: 1759-5045, DOI: 10.1038/s41575-018-0094-6	Nature Reviews Gastroenterology & Hepatology 16/2	2020-01-29
2019	Carolin Lackner, Dina Tiniakos Fibrosis and alcohol-related liver disease published pages: 294-304, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.12.003	Journal of Hepatology 70/2	2020-01-29
2019	Nadine Gehrke, Jana Biedenbach, Yvonne Huber, Beate K. Straub, Peter R. Galle, Perikles Simon, JÃ¶rn M. Schattenberg Voluntary exercise in mice fed an obesogenic diet alters the hepatic immune phenotype and improves metabolic parameters â€“ an animal model of life style intervention in NAFLD published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-38321-9	Scientific Reports 9/1	2020-01-29
2017	Younes, Ramy; Rosso, Chiara; Melania, Gaggini; Lavinia, Mezzabotta; Marietti, Milena; Fabrizia, Carli; Federico, Salomone; Emma, Buzzigoli; Caviglia, GIAN PAOLO; Chiara, Barbieri; Abate, Maria Lorena; Smedile, Antonina; Saracco, Giorgio Maria; Anstee, Quentin M.; Leeming, Diana J.; Amalia, Gastaldelli; Detlef, Schuppan; Bugianesi, Elisabetta Insulin secretion and decreased glucose clearance are associated with enhanced fibrogenesis and a high risk of disease progression in non-diabetic patients with Non Alcoholic Fatty Liver Disease published pages: , ISSN: , DOI:	9	2020-01-29
2019	Brandon D. Kayser, Marie Lhomme, Edi Prifti, Carla Da Cunha, Florian Marquet, Florian Chain, Isabelle Naas, VÃ©ronique Pelloux, Maria-Carlota Dao, Anatol Kontush, Salwa W. Rizkalla, Judith Aron-Wisnewsky, Luis G. BermÃºdez-HumarÃ¡n, Fiona Oakley, Philippe Langella, Karine ClÃ©ment, Isabelle Dugail Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity published pages: 4741-4754, ISSN: 0892-6638, DOI: 10.1096/fj.201801897r	The FASEB Journal 33/4	2020-01-29
2016	You Zhou, Matej OreÅ¡iÄ, Marja Leivonen, Peddinti Gopalacharyulu, Jenni Hyysalo, Johanna Arola, An Verrijken, Sven Francque, Luc Van Gaal, Tuulia HyÃ¶tylÃ¤inen, Hannele Yki-JÃ¤rvinen Noninvasive Detection of Nonalcoholic Steatohepatitis UsingÂ Clinical Markers and Circulating Levels of Lipids andÂ Metabolites published pages: 1463-1472.e6, ISSN: 1542-3565, DOI: 10.1016/j.cgh.2016.05.046	Clinical Gastroenterology and Hepatology 14/10	2020-01-29
2017	Salvatore Petta, Mohammed Eslam, Luca Valenti, Elisabetta Bugianesi, Marco Barbara, Calogero CammÃ , Marianna Porzio, Chiara Rosso, Silvia Fargion, Jacob George, Antonio CraxÃ¬ Metabolic syndrome and severity of fibrosis in nonalcoholic fatty liver disease: An age-dependent risk profiling study published pages: 1389-1396, ISSN: 1478-3223, DOI: 10.1111/liv.13397	Liver International 37/9	2020-01-29
2018	Panu K. Luukkonen, Sanja SÃ¤devirta, You Zhou, Brandon Kayser, Ashfaq Ali, Linda Ahonen, Susanna Lallukka, VÃ©ronique Pelloux, Melania Gaggini, Ching Jian, Antti Hakkarainen, Nina Lundbom, Helena Gylling, Anne Salonen, Matej OreÅ¡iÄ, Tuulia HyÃ¶tylÃ¤inen, Marju Orho-Melander, Aila Rissanen, Amalia Gastaldelli, Karine ClÃ©ment, Leanne Hodson, Hannele Yki-JÃ¤rvinen Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars published pages: 1732-1739, ISSN: 0149-5992, DOI: 10.2337/dc18-0071	Diabetes Care 41/8	2020-01-29
2017	Younes, R; Rosso, C; Marietti, M; Caviglia, Gp; NascÃ¨, A; Campion, D; Cantamessa, A; Carucci, P; Bugianesi, E Hepatocellular carcinoma and metabolic risk factors in a main reference center in Italy published pages: , ISSN: , DOI:	9	2020-01-29
2018	Lucette Flandroy, Theofilos Poutahidis, Gabriele Berg, Gerard Clarke, Maria-Carlota Dao, Ellen Decaestecker, Eeva Furman, Tari Haahtela, SÃ©bastien Massart, Hubert Plovier, Yolanda Sanz, Graham Rook The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems published pages: 1018-1038, ISSN: 0048-9697, DOI: 10.1016/j.scitotenv.2018.01.288	Science of The Total Environment 627	2020-01-29
2019	Ramy Younes, Elisabetta Bugianesi NASH in Lean Individuals published pages: 086-095, ISSN: 0272-8087, DOI: 10.1055/s-0038-1677517	Seminars in Liver Disease 39/01	2020-01-29
2018	Detlef Schuppan, Muhammad Ashfaq-Khan, Ai Ting Yang, Yong Ook Kim Liver fibrosis: Direct antifibrotic agents and targeted therapies published pages: 435-451, ISSN: 0945-053X, DOI: 10.1016/j.matbio.2018.04.006	Matrix Biology 68-69	2020-01-29
2018	Rosso, C.; Younes, R.; Eslam, M.; Chen, Fw.; Cucco, M.; Gaggini, M.; Coulter, S.; Carli, F.; Barbieri, C.; della Latta, V.; Abate, M. L.; Saracco, Gm.; Gastaldelli, A.; George, J.; Bugianesi, E. Bile acids composition modulate insulin resistance in non-diabetic patients with NAFLD published pages: , ISSN: , DOI:	21	2020-01-29
2017	Pierre Bedossa, Joan Tordjman, Judith Aron-Wisnewsky, Christine Poitou, Jean-Michel Oppert, Adriana Torcivia, Jean-Luc Bouillot, Valerie Paradis, Vlad Ratziu, Karine ClÃ©ment Systematic review of bariatric surgery liver biopsies clarifies the natural history of liver disease in patients with severe obesity published pages: 1688-1696, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2016-312238	Gut 66/9	2020-01-29
2018	Pierantonelli, G. Svegliati-Baroni I.; Younes, R.; Rosso, C.; Rychlicki, C.; Bugianesi, E.; Gastaldelli, A. Predisposition to diabetes is related to insulin resistance in NAFLD patients and to decreased insulin secretion in HCV patients published pages: , ISSN: , DOI:	5	2020-01-29
2018	Sergio Rodriguez-Cuenca, Stefania Carobbio, Gwendolyn BarcelÃ³-Coblijn, Xavier Prieur, Joana Relat, Ramon Amat, Mark Campbell, Ana Rita Dias, Myriam Bahri, Sarah L. Gray, Antonio Vidal-Puig P465L-PPARÎ³ mutation confers partial resistance to the hypolipidaemic action of fibrates published pages: 2339-2350, ISSN: 1462-8902, DOI: 10.1111/dom.13370	Diabetes, Obesity and Metabolism 20/10	2020-01-29
2016	Rosso, Chiara; Kazankov, K.; Marietti, Milena; Gaggini, M.; Buzzigoli, E.; MÃ¸ller, H. J.; Caviglia, GIAN PAOLO; Abate, Maria Lorena; Smedile, Antonina; Saracco, Giorgio Maria; Vilstrup, H.; Gastaldelli, A.; George, J.; GrÃ¸nbÃ¦k, H.; Bugianesi, Elisabetta Hepatic macrophage activation is associated with adipose tissue insulin resistance in non-diabetic patients with Non-Alcoholic Fatty Liver Disease published pages: , ISSN: , DOI:	12	2020-01-29
2019	Geoff Farrell, JÃ¶rn M. Schattenberg, Isabelle Leclercq, Matthew M. Yeh, Robert Goldin, Narci Teoh, Detlef Schuppan Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis published pages: 2241-2257, ISSN: 0270-9139, DOI: 10.1002/hep.30333	Hepatology 69/5	2020-01-29
2019	Konstantin Kazankov, Simon Mark Dahl JÃ¸rgensen, Karen Louise Thomsen, Holger Jon MÃ¸ller, Hendrik Vilstrup, Jacob George, Detlef Schuppan, Henning GrÃ¸nbÃ¦k The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis published pages: 145-159, ISSN: 1759-5045, DOI: 10.1038/s41575-018-0082-x	Nature Reviews Gastroenterology & Hepatology 16/3	2020-01-29
2017	Panu K. Luukkonen, You Zhou, Elina Isokuortti, Marja Leivonen, Anne Juuti, Antti Hakkarainen, Marju Orho-Melander, Nina Lundbom, Vesa M. Olkkonen, Riitta Lassila, Hannele Yki-JÃ¤rvinen, Susanna Lallukka Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans published pages: 286-294, ISSN: 0340-6245, DOI: 10.1160/TH16-09-0716	Thrombosis and Haemostasis 117/02	2019-12-17
2017	Amalia Gastaldelli, Melania Gaggini, Ralph DeFronzo Glucose kinetics published pages: 300-309, ISSN: 1363-1950, DOI: 10.1097/MCO.0000000000000384	Current Opinion in Clinical Nutrition and Metabolic Care 20/4	2019-12-17
2016	Tuulia HyÃ¶tylÃ¤inen, Livnat Jerby, Elina M. PetÃ¤jÃ¤, Ismo Mattila, Sirkku JÃ¤ntti, Petri Auvinen, Amalia Gastaldelli, Hannele Yki-JÃ¤rvinen, Eytan Ruppin, Matej OreÅ¡iÄ Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease published pages: 8994, ISSN: 2041-1723, DOI: 10.1038/ncomms9994	Nature Communications 7	2019-12-17
2016	Morten A. Karsdal, Kim Henriksen, Mette Juul Nielsen, Inger Byrjalsen, Diana J. Leeming, Stephen Gardner, Zachary Goodman, Keyur Patel, Aleksander Krag, Claus Christiansen, Detlef Schuppan Fibrogenesis assessed by serological type III collagen formation identifies patients with progressive liver fibrosis and responders to a potential antifibrotic therapy published pages: G1009-G1017, ISSN: 0193-1857, DOI: 10.1152/ajpgi.00283.2016	American Journal of Physiology-Gastrointestinal and Liver Physiology 311/6	2019-12-17
2017	B D Kayser, M Lhomme, M C Dao, F Ichou, J-L Bouillot, E Prifti, A Kontush, J-M Chevallier, J Aron-Wisnewsky, I Dugail, K ClÃ©ment Serum lipidomics reveals early differential effects of gastric bypass compared with banding on phospholipids and sphingolipids independent of differences in weight loss published pages: 917-925, ISSN: 0307-0565, DOI: 10.1038/ijo.2017.63	International Journal of Obesity 41/6	2019-12-17
2017	Benedetta Donati, Paola Dongiovanni, Stefano Romeo, Marica Meroni, Misti McCain, Luca Miele, Salvatore Petta, Silvia Maier, Chiara Rosso, Laura De Luca, Ester Vanni, Stefania Grimaudo, Renato Romagnoli, Fabio Colli, Flaminia Ferri, Rosellina Margherita Mancina, Paula Iruzubieta, Antonio Craxi, Anna Ludovica Fracanzani, Antonio Grieco, Stefano Ginanni Corradini, Alessio Aghemo, Massimo Colombo, Giorgio Soardo, Elisabetta Bugianesi, Helen Reeves, Quentin M. Anstee, Silvia Fargion, Luca Valenti MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-04991-0	Scientific Reports 7/1	2019-12-17
2018	Melania Gaggini, Fabrizia Carli, Chiara Rosso, Emma Buzzigoli, Milena Marietti, Veronica Della Latta, Demetrio Ciociaro, Maria Lorena Abate, Roberto Gambino, Maurizio Cassader, Elisabetta Bugianesi, Amalia Gastaldelli Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance published pages: 145-158, ISSN: 0270-9139, DOI: 10.1002/hep.29465	Hepatology 67/1	2019-12-17
2017	Elina Isokuortti, You Zhou, Markku Peltonen, Elisabetta Bugianesi, Karine Clement, Dominique Bonnefont-Rousselot, Jean-Marc Lacorte, Amalia Gastaldelli, Detlef Schuppan, JÃ¶rn M. Schattenberg, Antti Hakkarainen, Nina Lundbom, Pekka Jousilahti, Satu MÃ¤nnistÃ¶, Sirkka KeinÃ¤nen-Kiukaanniemi, Juha Saltevo, Quentin M. Anstee, Hannele Yki-JÃ¤rvinen Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study published pages: 1873-1882, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4340-1	Diabetologia 60/10	2019-12-17
2018	Marie Boyle, Steven Masson, Quentin M. Anstee The bidirectional impacts of alcohol consumption and the metabolic syndrome: Cofactors for progressive fatty liver disease published pages: 251-267, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.11.006	Journal of Hepatology 68/2	2019-12-17
2017	Shabnam Shalapour, Xue-Jia Lin, Ingmar N. Bastian, John Brain, Alastair D. Burt, Alexander A. Aksenov, Alison F. Vrbanac, Weihua Li, Andres Perkins, Takaji Matsutani, Zhenyu Zhong, Debanjan Dhar, Jose A. Navas-Molina, Jun Xu, Rohit Loomba, Michael Downes, Ruth T. Yu, Ronald M. Evans, Pieter C. Dorrestein, Rob Knight, Christopher Benner, Quentin M. Anstee, Michael Karin Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity published pages: 340-345, ISSN: 0028-0836, DOI: 10.1038/nature24302	Nature 551/7680	2019-12-17
2018	Elisabetta Morello, Salvatore Sutti, Beatrice Foglia, Erica Novo, Stefania Cannito, Claudia Bocca, Martina Rajsky, Stefania BruzzÃ¬, Maria Lorena Abate, Chiara Rosso, Cristina Bozzola, Ezio David, Elisabetta Bugianesi, Emanuele Albano, Maurizio Parola Hypoxia-inducible factor 2Î± drives nonalcoholic fatty liver progression by triggering hepatocyte release of histidine-rich glycoprotein published pages: 2196-2214, ISSN: 0270-9139, DOI: 10.1002/hep.29754	Hepatology 67/6	2019-12-17
2017	Jake P. Mann, Quentin M. Anstee NAFLD: PNPLA3 and obesity: a synergistic relationship in NAFLD published pages: 506-507, ISSN: 1759-5045, DOI: 10.1038/nrgastro.2017.74	Nature Reviews Gastroenterology & Hepatology 14/9	2019-12-17
2017	Panu K. Luukkonen, You Zhou, P.A. Nidhina Haridas, Om P. Dwivedi, Tuulia HyÃ¶tylÃ¤inen, Ashfaq Ali, Anne Juuti, Marja Leivonen, Taru Tukiainen, Linda Ahonen, Emma Scott, Jeremy M. Palmer, Johanna Arola, Marju Orho-Melander, Petter Vikman, Quentin M. Anstee, Vesa M. Olkkonen, Matej OreÅ¡iÄ, Leif Groop, Hannele Yki-JÃ¤rvinen Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD published pages: 128-136, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.02.014	Journal of Hepatology 67/1	2019-12-17
2015	Hannele Yki-JÃ¤rvinen Nutritional Modulation of Non-Alcoholic Fatty Liver Disease and Insulin Resistance published pages: 9127-9138, ISSN: 2072-6643, DOI: 10.3390/nu7115454	Nutrients 7/11	2019-12-17
2017	Zobair Younossi, Quentin M. Anstee, Milena Marietti, Timothy Hardy, Linda Henry, Mohammed Eslam, Jacob George, Elisabetta Bugianesi Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention published pages: 11-20, ISSN: 1759-5045, DOI: 10.1038/nrgastro.2017.109	Nature Reviews Gastroenterology & Hepatology 15/1	2019-12-17
2018	Detlef Schuppan, Rambabu Surabattula, Xiao Yu Wang Determinants of fibrosis progression and regression in NASH published pages: 238-250, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.11.012	Journal of Hepatology 68/2	2019-12-17
2017	M.A. Karsdal, S.H. Nielsen, D.J. Leeming, L.L. Langholm, M.J. Nielsen, T. Manon-Jensen, A. Siebuhr, N.S. Gudmann, S. RÃ¸nnow, J.M. Sand, S.J. Daniels, J.H. Mortensen, D. Schuppan The good and the bad collagens of fibrosis â€“ Their role in signaling and organ function published pages: 43-56, ISSN: 0169-409X, DOI: 10.1016/j.addr.2017.07.014	Advanced Drug Delivery Reviews 121	2019-12-17
2017	Zoe Hall, Nicholas J. Bond, Tom Ashmore, Francis Sanders, Zsuzsanna Ament, Xinzhu Wang, Andrew J. Murray, Elena Bellafante, Sam Virtue, Antonio Vidal-Puig, Michael Allison, Susan E. Davies, Albert Koulman, Michele Vacca, Julian L. Griffin Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease published pages: 1165-1180, ISSN: 0270-9139, DOI: 10.1002/hep.28953	Hepatology 65/4	2019-12-17
2016	Elina PetÃ¤jÃ¤, Hannele Yki-JÃ¤rvinen Definitions of Normal Liver Fat and the Association of Insulin Sensitivity with Acquired and Genetic NAFLDâ€”A Systematic Review published pages: 633, ISSN: 1422-0067, DOI: 10.3390/ijms17050633	International Journal of Molecular Sciences 17/5	2019-12-17
2018	Ramy Younes, Elisabetta Bugianesi Should we undertake surveillance for HCC in patients with NAFLD? published pages: 326-334, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.10.006	Journal of Hepatology 68/2	2019-12-17
2016	Stuart McPherson, Tim Hardy, Jean-Francois Dufour, Salvatore Petta, Manuel Romero-Gomez, Mike Allison, Claudia P Oliveira, Sven Francque, Luc Van Gaal, JÃ¶rn M Schattenberg, Dina Tiniakos, Alastair Burt, Elisabetta Bugianesi, Vlad Ratziu, Christopher P Day, Quentin M Anstee Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis published pages: 740-751, ISSN: 0002-9270, DOI: 10.1038/ajg.2016.453	The American Journal of Gastroenterology 112/5	2019-12-17
2016	Panu K. Luukkonen, You Zhou, Tuulia HyÃ¶tylÃ¤inen, Marja Leivonen, Johanna Arola, Marju Orho-Melander, Matej OreÅ¡iÄ, Hannele Yki-JÃ¤rvinen The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans published pages: 1263-1265, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2016.07.045	Journal of Hepatology 65/6	2019-12-17
2017	Amalia Gastaldelli, Melania Gaggini, Ralph A. DeFronzo Role of Adipose Tissue Insulin Resistance in the Natural History of Type 2 Diabetes: Results From the San Antonio Metabolism Study published pages: 815-822, ISSN: 0012-1797, DOI: 10.2337/db16-1167	Diabetes 66/4	2019-12-17
2016	Elina M. PetÃ¤jÃ¤, You Zhou, Marika Havana, Antti Hakkarainen, Nina Lundbom, Jarkko Ihalainen, Hannele Yki-JÃ¤rvinen Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD published pages: , ISSN: 2045-2322, DOI: 10.1038/srep24740	Scientific Reports 6/1	2019-12-17
2017	Leon A Adams, Quentin M Anstee, Herbert Tilg, Giovanni Targher Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases published pages: 1138-1153, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2017-313884	Gut 66/6	2019-12-17
2017	Susanna Lallukka, Sanja SÃ¤devirta, Markus T. Kallio, Panu K. Luukkonen, You Zhou, Antti Hakkarainen, Nina Lundbom, Marju Orho-Melander, Hannele Yki-JÃ¤rvinen Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) â€“ an 11-Year Prospective Study published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-14706-0	Scientific Reports 7/1	2019-12-17
2016	Chiara Rosso, Lavinia Mezzabotta, Melania Gaggini, Federico Salomone, Roberto Gambino, Andrea Marengo, Francesca Saba, Ester Vanni, Rami I.K. Jouness, Chiara Saponaro, Emma Buzzigoli, Gian Paolo Caviglia, Maria Lorena Abate, Antonina Smedile, Mario Rizzetto, Maurizio Cassader, Amalia Gastaldelli, Elisabetta Bugianesi Peripheral insulin resistance predicts liver damage in nondiabetic subjects with nonalcoholic fatty liver disease published pages: 107-116, ISSN: 0270-9139, DOI: 10.1002/hep.28287	Hepatology 63/1	2019-12-17
2015	Ann Daly, Christopher Day, Quentin Anstee Genetics of Alcoholic Liver Disease published pages: 361-374, ISSN: 0272-8087, DOI: 10.1055/s-0035-1567832	Seminars in Liver Disease 35/04	2019-12-17
2016	Timothy Hardy, Fiona Oakley, Quentin M. Anstee, Christopher P. Day Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum published pages: 451-496, ISSN: 1553-4006, DOI: 10.1146/annurev-pathol-012615-044224	Annual Review of Pathology: Mechanisms of Disease 11/1	2019-12-17
2015	Michael Allison, Julian Griffin, Michele Vacca, Antonio Vidal-Puig Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD published pages: 250-261, ISSN: 0272-8087, DOI: 10.1055/s-0035-1562945	Seminars in Liver Disease 35/03	2019-12-17
2017	Morten A. Karsdal, Kim Henriksen, Federica Genovese, Diana J. Leeming, Mette J. Nielsen, Bente J. Riis, Claus Christiansen, Inger Byrjalsen, Detlef Schuppan Serum endotrophin identifies optimal responders to PPARÎ³ agonists in type 2 diabetes published pages: 50-59, ISSN: 0012-186X, DOI: 10.1007/s00125-016-4094-1	Diabetologia 60/1	2019-12-17
2015	Christopher Day, Quentin Anstee The Genetics of Nonalcoholic Fatty Liver Disease: Spotlight on PNPLA3 and TM6SF2 published pages: 270-290, ISSN: 0272-8087, DOI: 10.1055/s-0035-1562947	Seminars in Liver Disease 35/03	2019-12-17
2016	M. Noureddin, Q. M. Anstee, R. Loomba Review article: emerging anti-fibrotic therapies in the treatment of non-alcoholic steatohepatitis published pages: 1109-1123, ISSN: 0269-2813, DOI: 10.1111/apt.13620	Alimentary Pharmacology & Therapeutics 43/11	2019-12-17
2016	Quentin M. Anstee, Devanshi Seth, Christopher P. Day Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease published pages: 1728-1744.e7, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2016.01.037	Gastroenterology 150/8	2019-12-17
2016	Timothy Hardy, Mujdat Zeybel, Christopher P Day, Christian Dipper, Steven Masson, Stuart McPherson, Elsbeth Henderson, Dina Tiniakos, Steve White, Jeremy French, Derek A Mann, Quentin M Anstee, Jelena Mann Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease published pages: gutjnl-2016-3115, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2016-311526	Gut 0, 1-8	2019-12-17

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