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CIRCODE SIGNED

Cell-type specific mechanisms regulating rhythms in leukocyte homing

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CIRCODE project word cloud

Explore the words cloud of the CIRCODE project. It provides you a very rough idea of what is the project "CIRCODE" about.

course tissue signature chronobiology trafficking day 24 minimize inflammatory arrhythmicities lineage endothelial predicting maximize infarction diseases infiltration components proteomics hour code activation rhythmic cells model combines times space drugs disciplines infections fight proper body unprecedented time option immunology sepsis pharmacological tools steady molecular techniques mechanisms leukocytes clinical myocardial unknown poised vaccinations regulators tissues dimensional create cell obtaining genetic epigenetics therapy repair functionally regulate homeostasis broad oscillations extensive oscillating leukocyte impacts traffic provides data migration organs orchestrate circadian daily completely dictates combination function patterns immune altering map innovative rhythms

Project "CIRCODE" data sheet

The following table provides information about the project.

Coordinator	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://scheiermannlab.de/
Total cost	1˙497˙688 €
EC max contribution	1˙497˙688 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	coordinator	1˙497˙688.00

Map

Project objective

Leukocytes are the key components of the immune system that fight infections and provide tissue repair, yet their migration patterns throughout the body over the course of a day are completely unknown. Circadian, ~24 hour rhythms are emerging as important novel regulators of immune cell migration and function, which impacts inflammatory diseases such as myocardial infarction and sepsis. Altering leukocyte tissue infiltration and activation at the proper times provides an option for therapy that would maximize the clinical impact of drugs and vaccinations and minimize side effects. We aim to create a four-dimensional map of leukocyte migration to organs in time and space and investigate with epigenetics techniques the molecular mechanisms that regulate cell-type specific rhythms. We will functionally define the daily oscillating molecular signature(s) of leukocytes and endothelial cells with novel proteomics approaches and thus identify a circadian traffic code that dictates the rhythmic migration of leukocyte subsets to specific organs under steady-state and inflammatory conditions with pharmacological and genetic tools. We will assess the impact of lineage-specific arrhythmicities on immune homeostasis and leukocyte trafficking using an innovative combination of novel genetic tools. Based on these data we will create a model predicting circadian leukocyte migration to tissues. The project combines the disciplines of immunology and chronobiology by obtaining unprecedented information in time and space of circadian leukocyte trafficking and investigating how immune-cell specific oscillations are generated at the molecular level, which is of broad impact for both fields. Our extensive experience in the rhythmic control of the immune system makes us well poised to characterize the molecular components that orchestrate circadian leukocyte distribution across the body.

Publications

List of publications.
year	authors and title	journal	last update
2020	Sophia Hergenhan, Stephan Holtkamp, Christoph Scheiermann Molecular Interactions Between Components of the Circadian Clock and the Immune System published pages: , ISSN: 0022-2836, DOI: 10.1016/j.jmb.2019.12.044	Journal of Molecular Biology	2020-04-01
2019	Robert Pick, Wenyan He, Chien-Sin Chen, Christoph Scheiermann Time-of-Day-Dependent Trafficking and Function of Leukocyte Subsets published pages: 524-537, ISSN: 1471-4906, DOI: 10.1016/j.it.2019.03.010	Trends in Immunology 40/6	2020-04-01
2019	Alba de Juan, Louise Madeleine Ince, Robert Pick, Chien-Sin Chen, Filippo Molica, Gabriele Zuchtriegel, Chen Wang, Dachuan Zhang, David Druzd, Maximilian E.T. Hessenauer, Graziano Pelli, Isa Kolbe, Henrik Oster, Colette Prophete, Sophia Martina Hergenhan, Urs Albrecht, JÃ¼rgen Ripperger, Eloi Montanez, Christoph A. Reichel, Oliver Soehnlein, Brenda R. Kwak, Paul S. Frenette, Christoph Scheiermann Artery-Associated Sympathetic Innervation Drives Rhythmic Vascular Inflammation of Arteries and Veins published pages: 1100-1114, ISSN: 0009-7322, DOI: 10.1161/circulationaha.119.040232	Circulation 140/13	2020-04-01
2019	Louise M. Ince, Jasmin Weber, Christoph Scheiermann Control of Leukocyte Trafficking by Stress-Associated Hormones published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.03143	Frontiers in Immunology 9	2019-04-25
2018	Wenyan He, Stephan Holtkamp, Sophia Martina Hergenhan, Kerstin Kraus, Alba de Juan, Jasmin Weber, Paul Bradfield, Julien Martin Pierre Grenier, Jeoffrey Pelletier, David Druzd, Chien-Sin Chen, Louise Madeleine Ince, Susanne Bierschenk, Robert Pick, Markus Sperandio, Michel Aurrand-Lions, Christoph Scheiermann Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues published pages: 1175-1190.e7, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2018.10.007	Immunity 49/6	2019-04-25
2016	Steffens, S; Drechsler, M.; C. Weber; Duchene, J.; Scheiermann, C.; Horckmans, M; Nitz, K.; Bidzhekov, K.; Schloss, M.J.; Soehnlein, O. The time-of-day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment published pages: 937-948, ISSN: 1757-4684, DOI: 10.15252/emmm.201506083	EMBO Molecular Medicine 8	2019-06-04
2018	Christoph Scheiermann, Julie Gibbs, Louise Ince, Andrew Loudon Clocking in to immunity published pages: 423-437, ISSN: 1474-1733, DOI:	Nature Reviews Immunology 18/7	2019-06-04
2017	Druzd D, Matveeva O, Ince L, Harrison U, He W, Schmal C, Herzel H, Tsang AH, Kawakami N, Leliavski A, Uhl O, Yao L, Sander LE, Chen CS, Kraus K, de Juan A, Hergenhan SM, Ehlers M, Koletzko B, Haas R, Solbach W, Oster H, Scheiermann C. Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses published pages: Pages 120â€“132, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2016.12.011	Immunity Volume 46, Issue 1	2019-06-04

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