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CELL HYBRIDGE SIGNED

3D Scaffolds as a Stem Cell Delivery System for Musculoskeletal Regenerative Medicine

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CELL HYBRIDGE project word cloud

Explore the words cloud of the CELL HYBRIDGE project. It provides you a very rough idea of what is the project "CELL HYBRIDGE" about.

inspired biomimetic proliferation approached engineering potency permanently milieu designed quiescence demonstrated matrix causes lineages ups insufficient substrates evaluation engineered cellular degeneration implantation revealed restore homeostasis stem repair solutions material first cells maintaining aging play cascade stability extra mesenchymal lack excellent cultured regenerative constructs criteria prove healthcare follow cell designing integration surrounding actively tissues time therapies enhanced worldwide population reducing differentiation ecm medicine alternative instructive scaffolds demands trials offers musculoskeletal tissue multiple dimensional purpose damaged situ niche initial clinical signals interactions scaffold combined

Project "CELL HYBRIDGE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.moronilab.org
Total cost	1˙500˙000 €
EC max contribution	1˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2020-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	coordinator	1˙500˙000.00

Map

Project objective

Aging worldwide population demands new solutions to permanently restore damaged tissues, thus reducing healthcare costs. Regenerative medicine offers alternative therapies for tissue repair. Although first clinical trials revealed excellent initial response after implantation of these engineered tissues, long-term follow-ups demonstrated that degeneration and lack of integration with the surrounding tissues occur. Causes are related to insufficient cell-material interactions and loss of cell potency when cultured in two-dimensional substrates, among others. Stem cells are a promising alternative due to their differentiation potential into multiple lineages. Yet, better control over cell-material interactions is necessary to maintain tissue engineered constructs in time. It is crucial to control stem cell quiescence, proliferation and differentiation in three-dimensional scaffolds while maintaining cells viable in situ. Stem cell activity is controlled by a complex cascade of signals called “niche”, where the extra-cellular matrix (ECM) surrounding the cells play a major role. Designing scaffolds inspired by this cellular niche and its ECM may lead to engineered tissues with instructive properties characterized by enhanced homeostasis, stability and integration with the surrounding milieu. This research proposal aims at engineering constructs where scaffolds work as stem cell delivery systems actively controlling cell quiescence, proliferation, and differentiation. This challenge will be approached through a biomimetic design inspired by the mesenchymal stem cell niche. Three different scaffolds will be combined to achieve this purpose: (i) a scaffold designed to maintain cell quiescence; (ii) a scaffold designed to promote cell proliferation; and (iii) a scaffold designed to control cell differentiation. To prove the design criteria the evaluation of stem cell quiescence, proliferation, and differentiation will be assessed for musculoskeletal regenerative therapies.

Publications

List of publications.
year	authors and title	journal	last update
2019	Sandra Camarero-Espinosa, Andrea Calore, Arnold Wilbers, Jules Harings, Lorenzo Moroni Additive manufacturing of an elastic poly(ester)urethane for cartilage tissue engineering published pages: , ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.11.041	Acta Biomaterialia	2019-12-16
2019	Honglin Chen, Danielle F. Baptista, Giuseppe Criscenti, JoÃ£o Crispim, Hugo Fernandes, Clemens van Blitterswijk, Roman TruckenmÃ¼ller, Lorenzo Moroni From fiber curls to mesh waves: a platform for the fabrication of hierarchically structured nanofibers mimicking natural tissue formation published pages: 14312-14321, ISSN: 2040-3364, DOI: 10.1039/c8nr10108f	Nanoscale 11/30	2019-12-16
2019	Jip Zonderland, Paul Wieringa, Lorenzo Moroni A quantitative method to analyse F-actin distribution in cells published pages: 2562-2569, ISSN: 2215-0161, DOI: 10.1016/j.mex.2019.10.018	MethodsX 6	2019-12-16
2017	Honglin Chen, Xiaobin Huang, Minmin Zhang, Febriyani Damanik, Matthew B. Baker, Anne Leferink, Huipin Yuan, Roman TruckenmÃ¼ller, Clemens van Blitterswijk, Lorenzo Moroni Tailoring surface nanoroughness of electrospun scaffolds for skeletal tissue engineering published pages: 82-93, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.07.003	Acta Biomaterialia 59	2019-05-27
2018	Honglin Chen, Xiaobin Huang, Minmin Zhang, Febriyani Damanik, Matthew B. Baker, Anne Leferink, Huipin Yuan, Roman TruckenmÃ¼ller, Clemens van Blitterswijk, Lorenzo Moroni Corrigendum to â€œTailoring surface nanoroughness of electrospun scaffolds for skeletal tissue engineeringâ€ Acta Biomater. 59 (2017) 82â€“93 published pages: , ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.01.030	Acta Biomaterialia	2019-05-27

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The information about "CELL HYBRIDGE" are provided by the European Opendata Portal: CORDIS opendata.