COSIP SIGNED
Clarifying Optimal Sodium Intake Project
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the COSIP project. It provides you a very rough idea of what is the project "COSIP" about.
Project "COSIP" data sheet
The following table provides information about the project.
| Coordinator |
NATIONAL UNIVERSITY OF IRELAND GALWAY
Organization address contact info |
| Coordinator Country | Ireland [IE] |
| Project website | https://clinicaltrials.gov/ct2/show/NCT02738736 |
| Total cost | 1˙499˙431 € |
| EC max contribution | 1˙499˙431 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-05-01 to 2020-04-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | NATIONAL UNIVERSITY OF IRELAND GALWAY | IE (Galway) | coordinator | 1˙499˙431.00 |
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Project objective
Hypertension is a leading risk factor for cardiovascular disease (CVD) globally, accounting for 25-35% of the population-attributable fraction. Sodium (salt) intake is a key determinant of blood pressure, and reducing sodium intake has emerged as an important target for population-based interventions to prevent CVD. However, there is considerable uncertainty about the optimal level of sodium (salt) intake that is associated with lowest CVD risk, and whether optimal levels differ for different populations and individuals. In this proposal, we will answer key fundamental research questions about the association of sodium intake with blood pressure and CVD risk. Our research challenges current guideline recommendations of low-sodium intake for all populations. Specifically, we will: a) determine whether sustained (long-term) low sodium intake is associated with beneficial (or adverse) effects on established and novel CV biomarkers. b) explore whether inter-daily ‘pattern’ of sodium intake is an important determinant of 24-hour blood pressure pattern; c) determine whether the association between sodium intake and CVD varies by ethnicity, sex, age, other dietary factors (e.g. potassium intake), or other factors in 2 large international epidemiologic studies (PURE and INTERSTROKE; n>125,000 individuals). d) quantify the population-attributable fraction of excess sodium intake on global burden of CVD (stroke, myocardial infarction, heart failure and CV death), and model the potential impact of various population-based approaches to reducing sodium intake; e) determine whether sodium intake is associated with other vascular-related clinical conditions, namely including atrial fibrillation, cognitive impairment and falls (providing novel information); f) determine whether genetic variants associated with ‘salt sensitivity’ and hypertension are association with blood pressure and stroke, and whether these associations are modified by sodium intake.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2016 |
John Ferguson, Alberto Alvarez-Iglesias, John Newell, John Hinde, Martin O’Donnell Estimating average attributable fractions with confidence intervals for cohort and case–control studies published pages: 1141-1152, ISSN: 0962-2802, DOI: 10.1177/0962280216655374 |
Statistical Methods in Medical Research 27/4 | 2020-04-17 |
| 2016 |
Andrew Mente, Martin O\'Donnell, Sumathy Rangarajan, Gilles Dagenais, Scott Lear, Matthew McQueen, Rafael Diaz, Alvaro Avezum, Patricio Lopez-Jaramillo, Fernando Lanas, Wei Li, Yin Lu, Sun Yi, Lei Rensheng, Romaina Iqbal, Prem Mony, Rita Yusuf, Khalid Yusoff, Andrzej Szuba, Aytekin Oguz, Annika Rosengren, Ahmad Bahonar, Afzalhussein Yusufali, Aletta Elisabeth Schutte, Jephat Chifamba, Johannes F E Mann, Sonia S Anand, Koon Teo, S Yusuf Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies published pages: 465-475, ISSN: 0140-6736, DOI: 10.1016/S0140-6736(16)30467-6 |
The Lancet 388/10043 | 2020-04-17 |
| 2016 |
Andrew Mente, Martin J. O’Donnell, Salim Yusuf How Robust Is the Evidence for Recommending Very Low Salt Intake in Entire Populations? ∗ published pages: 1618-1621, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2016.08.008 |
Journal of the American College of Cardiology 68/15 | 2020-04-17 |
| 2016 |
Martin O’Donnell, M.B., Ph.D.
National University of Ireland Galway, Galway, Ireland
martin.odonnell@nuigalway.ie
Johannes F.E. Mann, M.D.
Munich and Friedrich Alexander University, Erlangen–Nuremberg, Germany
Aletta E. Schutte, Ph.D.
North-West University, Potchefstroom, South Africa
Jan A. Staessen, M.D., Ph.D.
University of Leuven, Leuven, Belgium
Patricio Lopez-Jaramillo, M.D., Ph.D.
Fundación Oftalmológica de Santander, Floridablanca, Colombia
Merlin Thomas, M.B., Ch.B., Ph.D.
Baker IDI Heart and Diabetes Institute, Melbourne, VIC, Australia
Andrew Mente, Ph.D.
McMaster University, Hamilton, ON, Canada
Pierre J. Saulnier, M.D., Ph.D.
Centre Hospitalier Universitaire de Poitiers, Poitiers, France
Salim Yusuf, M.D., D.Phil.
McMaster University, Hamilton, ON, Canada Dietary Sodium and Cardiovascular Disease Risk published pages: 2404-2408, ISSN: 0028-4793, DOI: 10.1056/NEJMc1612304 |
New England Journal of Medicine 375/24 | 2020-04-17 |
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