Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. a cactus

A CACTUS

Antibody-free method for Counting All Circulating TUmour cellS while maintaining them alive and intact

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 A CACTUS project word cloud

Explore the words cloud of the A CACTUS project. It provides you a very rough idea of what is the project "A CACTUS" about.

patient    instead    meant    veridex    mesenchymal    presented    water    correctly    business    plan    provides    effect    antibody    rate    ctcs    consisting    oil    probing    droplets    fda    sites    glycolysis    fluidic    stream    liter    lung    display    detecting    bladder    isolate    enter    portfolio    gastric    detects    separating    pico    intact    approved    colon    alive    emulsions    epithelial    inexpensive    critical    deaths    metastases    tumour    strategy    ph    final    obvious    proper    characterising    investors    commercialisation    showed    count    induce    proposition    detection    proof    commercialising    diagnostic    surrounding    outcome    cytosol    assays    cactus    warburg    micro    aerobic    ctc    ip    maintaining    influence    volume    sorting    responsible    idea    microenvironment    attractive    metabolic    cancer    counting    blood    enzymatic    labelling    progression    90    dyes    detected    cells    environmental    cellsearch    circulating    lactate    metastatic    treatment    breast    feasibility    sensitive    prostate   

Project "A CACTUS" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITA DEGLI STUDI DI UDINE 

Organization address
address: VIA PALLADIO 8
city: UDINE
postcode: 33100
website: www.uniud.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Italy [IT]
 Total cost 149˙875 €
 EC max contribution 149˙875 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2016-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI UDINE IT (UDINE) coordinator 149˙875.00

Map

 Project objective

The problem: Cancer metastases are responsible for 90% of cancer-associated deaths. Circulating tumour cells (CTCs) that enter the blood stream on their way to potential metastatic sites are of obvious interest to evaluate correctly patient treatment and therefore influence outcome. CTCs have been identified in bladder, gastric, prostate, lung, breast and colon cancer. The only FDA approved CTCs detection system is Veridex’ CellSearch, which detects only epithelial cancer cells using antibody labelling. Recent evidence showed that non-epithelial cancer cells, which are not detected by CellSearch, are of critical importance in cancer progression.

The idea: Our CTC detection method is based, instead of on antibody labelling, on metabolic features of cancer cells, thus providing potential for detecting both epithelial and mesenchymal cancer cells. Cancer cells induce environmental changes; e.g. in aerobic conditions most cancer cells display a high rate of glycolysis with lactate production in the cytosol, known as the Warburg effect. By separating cells into micro-droplets of pico-liter volume using micro-fluidic water-in-oil emulsions and by characterising the microenvironment surrounding them, CTCs are detected by probing for environmental changes using pH sensitive dyes or enzymatic lactate assays. Our inexpensive diagnostic method provides a way to count and isolate CTCs without any labelling while maintaining cells alive and intact for further studies.

The project: “A CACTUS” is meant to assess the feasibility of commercialising the developed method for counting and sorting CTCs and develop a proper commercialisation strategy. The final goal of this project is to develop a proposition package consisting of technical proof of concept, the business proposition and strategy and an IP portfolio and strategy. This information will be presented in an attractive business plan that will be proposed to potential investors.

 Publications

year authors and title journal last update
List of publications.
2016 Fabio Del Ben, Matteo Turetta, Giorgia Celetti, Aigars Piruska, Michela Bulfoni, Daniela Cesselli, Wilhelm T. S. Huck, Giacinto Scoles
A Method for Detecting Circulating Tumor Cells Based on the Measurement of Single-Cell Metabolism in Droplet-Based Microfluidics
published pages: 8581-8584, ISSN: 1433-7851, DOI: 10.1002/anie.201602328 		Angewandte Chemie International Edition 55/30 2019-07-23

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "A CACTUS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "A CACTUS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

TRUST (2018)

Truth and Semantics

Read More  

GAIA (2020)

A Genomic and Macroevolutionary Approach to Studying Diversification in an Insect-Plant Arms Race

Read More  

ChronicPain (2019)

New Target and Drug Candidates for Alleviating Chronic Pain

Read More