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CARDIS

Early stage CARdio Vascular Disease Detection with Integrated Silicon Photonics

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CARDIS project word cloud

Explore the words cloud of the CARDIS project. It provides you a very rough idea of what is the project "CARDIS" about.

weight detection small heart met whenever parts contraction integrate silicon doppler guidelines intervention detectors cvd care individuals screening specs protect chip flow arterial early optical velocity micro disseminate stenosis create size undiagnosed model components vibrations vibrometer primary ip volumes classification validate cardis esc volume bench besides skin commercially economic biomechanical risk laser halt array subsystems screen invasive fast prediction optics commit identification point scalable underlying aortic setting mobile signals sub clinical reverse fabricate interferometer pathological moving stiffness translate pulse esh abnormalities tools too population transfer photonics medtronic device physiological events latest ge wave apwv driver integration social moderate cardiac

Project "CARDIS" data sheet

The following table provides information about the project.

Coordinator	INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM Organization address address: KAPELDREEF 75 city: LEUVEN postcode: 3001 website: www.imec.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Project website	http://www.cardis-h2020.eu
Total cost	3˙629˙207 €
EC max contribution	3˙629˙206 € (100%)
Programme	1. H2020-EU.2.1.1.6. (Micro- and nanoelectronics and photonics: Key enabling technologies related to micro- and nanoelectronics and to photonics, covering also quantum technologies)
Code Call	H2020-ICT-2014-1
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-02-01 to 2019-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM Organization address address: KAPELDREEF 75 city: LEUVEN postcode: 3001 website: www.imec.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	coordinator	721˙413.00
2	SIOS MESSTECHNIK SIOS MESSTECHNIK Organization address address: AM VOGELHERD 46 city: ILMENAU postcode: 98693 website: www.sios.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ILMENAU)	participant	662˙750.00
3	MEDTRONIC BAKKEN RESEARCH CENTER B.V. MEDTRONIC BAKKEN RESEARCH CENTER B.V. Organization address address: ENDEPOLSDOMEIN 5 city: MAASTRICHT postcode: 6229GW website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	602˙990.00
4	UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Organization address address: WESTERN ROAD city: Cork postcode: T12 YN60 website: www.ucc.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Cork)	participant	426˙579.00
5	UNIVERSITEIT GENT UNIVERSITEIT GENT Organization address address: SINT PIETERSNIEUWSTRAAT 25 city: GENT postcode: 9000 website: http://www.ugent.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (GENT)	participant	399˙500.00
6	QUEEN MARY UNIVERSITY OF LONDON QUEEN MARY UNIVERSITY OF LONDON Organization address address: 327 MILE END ROAD city: LONDON postcode: E1 4NS website: http://www.qmul.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	274˙059.00
7	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	215˙000.00
8	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	176˙915.00
9	FUNDICO BVBA FUNDICO BVBA Organization address address: GRUUTHUSELAAN 19 city: OOSTKAMP postcode: 8020 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (OOSTKAMP)	participant	150˙000.00

Map

Project objective

Early identification of individuals at risk for CVD allows early intervention to halt or reverse the pathological process. This is the driver of Medtronic and partners to develop a mobile, low-cost, non-invasive, point-of-care screening device for CVD.

Assessment of arterial stiffness by measurement of the aortic pulse wave velocity (aPWV) is included in the latest ESC/ESH guidelines for CVD risk prediction. Besides aPWV, early identification of arterial stenosis and cardiac contraction abnormalities can be used to improve CVD risk classification. However, no tools are available today to screen a large population at primary care on these parameters, and individuals that are considered to be at low or moderate risk are too often undiagnosed.

The objective of CARDIS is to investigate and demonstrate the concept of a mobile, low-cost device based on a silicon photonics integrated laser Doppler vibrometer and validate the concept for the screening of arterial stiffness, detection of stenosis and heart failure. We will: •Investigate, design and fabricate the optical subsystems and components: silicon photonics chip with integrated Ge-detectors, micro-optics, micro-optical laser bench, optical package •Integrate the subsystems and build a multi-array laser interferometer system •Develop a process flow scalable to high volumes for all sub-systems and their integration steps •Investigate and develop the biomechanical model to translate optical signals related to skin-level vibrations into underlying CVD physiological events •Validate the system in a clinical setting

Photonics integration is needed to enable a device that is mobile (small size, small weight, robust (no moving parts), low cost (high volume scalable process flow) and allows fast screening (laser array).

The partners commit to protect IP whenever possible, disseminate results via open access and, if target specs are met, commercially exploit and transfer the technology to create social and economic impact.

Deliverables

List of deliverables.
Evaluation of the clinical feasibility and validation of LDV for measurement of aortic and local PWV	Documents, reports	2020-02-07 12:45:49
Final Report	Documents, reports	2020-02-07 12:45:49
Press release at project end	Websites, patent fillings, videos etc.	2020-02-07 12:45:50
Evaluation of the clinical feasibility and validation of LDV for measurement of coronary stenosis	Documents, reports	2020-02-07 12:45:50
Evaluation of LDV measurements to assess cardiac pump function, globally and locally	Documents, reports	2020-02-07 12:45:50
Website online	Websites, patent fillings, videos etc.	2020-02-07 12:45:49
Press release at project start	Websites, patent fillings, videos etc.	2020-02-07 12:45:49

Take a look to the deliverables list in detail: detailed list of CARDIS deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Yanlu Li, Jinghao Zhu, Matthieu Duperron, Peter Oâ€™Brien, Ralf SchÃ¼ler, Soren Aasmul, Mirko de Melis, Mathias Kersemans, Roel Baets Six-beam homodyne laser Doppler vibrometry based on silicon photonics technology published pages: 3638, ISSN: 1094-4087, DOI: 10.1364/oe.26.003638	Optics Express 26/3	2020-02-07
2019	Viviana Mancini, Aslak W. Bergersen, Jan Vierendeels, Patrick Segers, Kristian Valen-Sendstad High-Frequency Fluctuations in Post-stenotic Patient Specific Carotid Stenosis Fluid Dynamics: A Computational Fluid Dynamics Strategy Study published pages: , ISSN: 1869-408X, DOI: 10.1007/s13239-019-00410-9	Cardiovascular Engineering and Technology	2020-02-07
2017	Matthieu Duperron, Lee Carroll, Marc Rensing, Sean Collins, Yan Zhao, Yanlu Li, Roel Baets, Peter O\'Brien Hybrid integration of laser source on silicon photonic integrated circuit for low-cost interferometry medical device published pages: 1010915, ISSN: , DOI: 10.1117/12.2250921	Optical Interconnects XVII	2020-02-07

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The information about "CARDIS" are provided by the European Opendata Portal: CORDIS opendata.