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TRYP-QS

YAK kinase regulated trypanosome quorum sensing

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TRYP-QS project word cloud

Explore the words cloud of the TRYP-QS project. It provides you a very rough idea of what is the project "TRYP-QS" about.

tsetse    parasite    molds    contributes    sophisticated    relevance    flies    training    limitation    saharan    bloodstream    parasites    sensing    optimise    extracellular    population    disease    vivo    transmission    environment    expertise    yeasts    molecule    humans    stumpy    almost    action    qs    vitro    transduction    spread    death    quorum    kinase    cytoplasm    signals    encompassing    sense    laboratory    components    exchange    dissect    trypanosomes    drive    screen    preparation    benefit    monitor    operates    regions    chances    function    cell    mechanisms    signalling    post    family    dyrk    livestock    signal    pivotal    hardship    exclusively    differ    specialised    feeding    regulation    arrest    forms    afflicted    transcriptional    nucleus    mrna    mammals    slime    quiescence    african    trypanosome    whilst    molecules    nutrient    proteins    sub    additional    expression    gene    researcher    rnai    situation    seems    interactions    cellular    kinetoplastids    act    africa    relocates    yak    density    location    communicate    blood    stages    host    malaria    genome   

Project "TRYP-QS" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://matthews.bio.ed.ac.uk
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-05   to  2017-05-04

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 183˙454.00

Map

 Project objective

African trypanosomes are parasites that cause disease in both humans and livestock throughout sub Saharan Africa, leading to death and hardship in afflicted regions. The disease is spread by blood-feeding tsetse flies and trypanosomes use sophisticated mechanisms to sense their environment in order to optimise their chances of transmission. In particular, whilst in the host bloodstream trypanosomes communicate with one another to monitor their own population density, this determining when they produce specialised transmission stages (so called ‘Stumpy’ forms). We have recently identified, using a genome-wide RNAi screen, components of the signal transduction pathway that drive this quorum sensing (QS) response. One component seems pivotal in the pathway- a molecule related to the YAK kinase of proteins. In yeasts and slime molds YAK kinase contributes to cell growth arrest in response to extracellular signals including nutrient limitation, whilst in mammals, related molecules of the DYRK family can also act in cellular quiescence. In this proposal we will investigate the function of trypanosome YAK kinase in the parasite's QS response. Specifically, we will investigate the kinase function in vitro and in vivo and dissect its action by following its location and targets. These are likely to differ from the situation in yeasts where YAK relocates to the nucleus and changes mRNA expression; in trypanosomes gene regulation is almost exclusively post transcriptional and likely operates within the cytoplasm. The function, location and interactions of YAK kinase in the QS signalling pathway is expected to provide comprehensive insight into how trypanosome parasites control their development in preparation for transmission, with additional important relevance for related parasites including other kinetoplastids and malaria. A two way benefit, encompassing training and expertise exchange between the researcher and host laboratory, will also be established.

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