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TRYP-QS

YAK kinase regulated trypanosome quorum sensing

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TRYP-QS project word cloud

Explore the words cloud of the TRYP-QS project. It provides you a very rough idea of what is the project "TRYP-QS" about.

nutrient    stumpy    transduction    mammals    signal    humans    operates    rnai    benefit    slime    transcriptional    mechanisms    flies    host    laboratory    saharan    parasites    relevance    seems    vitro    differ    monitor    transmission    regions    exchange    limitation    drive    specialised    interactions    feeding    signalling    signals    cytoplasm    spread    regulation    molecule    screen    environment    death    yak    encompassing    post    location    gene    bloodstream    nucleus    components    stages    dissect    livestock    proteins    trypanosome    disease    dyrk    function    extracellular    sophisticated    exclusively    molecules    training    cellular    preparation    vivo    mrna    sensing    communicate    whilst    hardship    kinase    africa    kinetoplastids    forms    additional    quorum    blood    act    contributes    trypanosomes    tsetse    parasite    qs    genome    almost    family    relocates    action    sub    density    situation    population    quiescence    expertise    arrest    african    chances    malaria    optimise    cell    researcher    expression    yeasts    molds    pivotal    sense    afflicted   

Project "TRYP-QS" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://matthews.bio.ed.ac.uk
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-05   to  2017-05-04

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 183˙454.00

Map

 Project objective

African trypanosomes are parasites that cause disease in both humans and livestock throughout sub Saharan Africa, leading to death and hardship in afflicted regions. The disease is spread by blood-feeding tsetse flies and trypanosomes use sophisticated mechanisms to sense their environment in order to optimise their chances of transmission. In particular, whilst in the host bloodstream trypanosomes communicate with one another to monitor their own population density, this determining when they produce specialised transmission stages (so called ‘Stumpy’ forms). We have recently identified, using a genome-wide RNAi screen, components of the signal transduction pathway that drive this quorum sensing (QS) response. One component seems pivotal in the pathway- a molecule related to the YAK kinase of proteins. In yeasts and slime molds YAK kinase contributes to cell growth arrest in response to extracellular signals including nutrient limitation, whilst in mammals, related molecules of the DYRK family can also act in cellular quiescence. In this proposal we will investigate the function of trypanosome YAK kinase in the parasite's QS response. Specifically, we will investigate the kinase function in vitro and in vivo and dissect its action by following its location and targets. These are likely to differ from the situation in yeasts where YAK relocates to the nucleus and changes mRNA expression; in trypanosomes gene regulation is almost exclusively post transcriptional and likely operates within the cytoplasm. The function, location and interactions of YAK kinase in the QS signalling pathway is expected to provide comprehensive insight into how trypanosome parasites control their development in preparation for transmission, with additional important relevance for related parasites including other kinetoplastids and malaria. A two way benefit, encompassing training and expertise exchange between the researcher and host laboratory, will also be established.

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