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NLRs

Mechanisms of natural auto immunity triggered by plant NLR immune receptors

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NLRs project word cloud

Explore the words cloud of the NLRs project. It provides you a very rough idea of what is the project "NLRs" about.

mechanisms editing reflected habitat activation hybrid repeat breeders immune lrr biochemical accessions pathologists largely leucine natural function nucleotide nb compare performance variation immunity interact exhaustively proteins binding extreme sequence plan family plant systematically trade off causal arabidopsis resistance loci explore reveal domains fitness knocking pathogen genes nlr genome inappropriately cellular necrosis unknown

Project "NLRs" data sheet

The following table provides information about the project.

Coordinator	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.weigelworld.org/research/hybrid-performance-and-immunity.html
Total cost	159˙460 €
EC max contribution	159˙460 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2017-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	coordinator	159˙460.00

Map

Project objective

Resistance (R) loci with nucleotide binding/leucine rich repeat (NB-LRR or NLR) domains have been identified as the major causal genes for hybrid necrosis, which presents an extreme example of the trade-off between plant growth and the activation of immune system. This is an exciting finding both for plant breeders and plant pathologists. However, how these NLR proteins or even the whole NLR family lead to hybrid necrosis, how they contribute to fitness under natural conditions, and how this is reflected in their extreme sequence variation remain largely unknown. In this proposal, I plan to exhaustively explore their function by systematically knocking out the NLR loci from genome of different Arabidopsis accessions using genome editing, and testing their fitness performance in the natural habitat. I will also reveal the cellular and biochemical mechanisms by which NLR proteins inappropriately interact with other cellular proteins to cause hybrid necrosis and compare the hybrid necrosis activity with pathogen induced immunity.

Publications

List of publications.
year	authors and title	journal	last update
2017	Xiuli Bi, Ying-Juan Cheng, Bo Hu, Xiaoli Ma, Rui Wu, Jia-Wei Wang, Chang Liu Nonrandom domain organization of the Arabidopsis genome at the nuclear periphery published pages: 1162-1173, ISSN: 1088-9051, DOI: 10.1101/gr.215186.116	Genome Research 27/7	2019-07-23
2017	Giovanna Capovilla, Efthymia Symeonidi, Rui Wu, Markus Schmid Contribution of major FLM isoforms to temperature-dependent flowering in Arabidopsis thaliana published pages: , ISSN: 0022-0957, DOI: 10.1093/jxb/erx328	Journal of Experimental Botany	2019-07-23

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