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BURK-6

Investigation of the Type VI secretion system-associated toxins of Burkholderia thailandensis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BURK-6 project word cloud

Explore the words cloud of the BURK-6 project. It provides you a very rough idea of what is the project "BURK-6" about.

intracellular pathogenic pseudomallei cells plant membrane exploitable antimicrobial akin conserved mutagenesis secretion stages bacteria uncover transposon six mechanisms vaccine throughput organism contractile effectors strategies organelle screening establishment virulence exposing made host context cellular repertoire diseases characterise life environmental infection eukaryotic saturation appropriate strategy onset little pathogenesis despite structurally thailandensis additionally bacterial hosts threatening infectious unavailable hijacked infecting machineries prokaryotic gram genome mammalian burkholderia negative surrogate tackle underlying dynamic t6ss reporter pathogens highlighted toxins co combination bound outcomes closely disciplinary technologies cross uncovering therapeutic phage tail

Project "BURK-6" data sheet

The following table provides information about the project.

Coordinator	LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER Organization address address: KEPPEL STREET city: LONDON postcode: WC1E 7HT website: http://www.lshtm.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	276˙107 €
EC max contribution	276˙107 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-GF
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2018-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER Organization address address: KEPPEL STREET city: LONDON postcode: WC1E 7HT website: http://www.lshtm.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	276˙107.00
2	UNIVERSITY OF MELBOURNE UNIVERSITY OF MELBOURNE Organization address address: PARKVILLEOFFICE OF THE VICE CHANCELLOR city: MELBOURNE postcode: 3010 website: www.unimelb.edu.au contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (MELBOURNE)	partner	0.00

Map

Project objective

Secretion systems are evolved machineries enabling bacteria to deliver toxins and virulence factors, called effectors, into target cells to enable the onset of infectious diseases. Uncovering these effectors is essential for the understanding of bacterial pathogenesis and the establishment of appropriate therapeutic strategies to tackle infectious diseases. The recently identified Type Six Secretion System (T6SS) is conserved in environmental and pathogenic Gram-negative bacteria. The T6SS is an organelle structurally akin to an intracellular and membrane-bound contractile phage tail used for the delivery of toxins into prokaryotic and eukaryotic target cells. The importance of this system in the context of infection is highlighted by its ability to not only target eukaryotic cells during bacterial infection, but additionally to target other bacteria co-infecting mammalian and plant hosts. Despite the recent advances made in understanding the mechanisms underlying the T6SS dynamic, very little is known about the T6SS effectors repertoire used by life-threatening pathogens, such as Burkholderia pseudomallei, and for which, vaccine strategies are currently unavailable. In the proposed research, a combination of high-throughput and cross-disciplinary technologies will be used to uncover and characterise novel T6SS effectors in B. thailandensis, a surrogate organism closely related to B. pseudomallei. This will 1) identify new T6SS effectors targeting eukaryotic cells, using a reporter-based transposon screening and 2) identify novel T6SS toxins targeting prokaryotic cells, using a genome-wide saturation mutagenesis strategy. The outcomes of the proposed research will identify the key cellular stages hijacked by the T6SS during the infection of a host, while exposing potential new bacterial targets exploitable for the development of novel antimicrobial strategies.

Publications

List of publications.
year	authors and title	journal	last update
2016	Abderrahman Hachani, Thomas E Wood, Alain Filloux Type VI secretion and anti-host effectors published pages: 81-93, ISSN: 1369-5274, DOI: 10.1016/j.mib.2015.11.006	Current Opinion in Microbiology 29	2019-06-13

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