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CREST UNDER TENSION TERMINATED

Mechano-regulation of neural crest cell differentiation.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CREST UNDER TENSION project word cloud

Explore the words cloud of the CREST UNDER TENSION project. It provides you a very rough idea of what is the project "CREST UNDER TENSION" about.

chondrocytes    additionally    fellow    differentiation    tensions    repair    populations    internationally    fate    population    ncc    vertebrate    biology    interdisciplinary    stem    evolution    chemicals    manipulated    actinomyosin    training    regulatory    exposed    mechanoregulatory    morphogenesis    vitro    craniofacial    vivo    generate    hypothesis    mechanisms    soluble    governed    birth    forefront    influence    effectors    crest    deal    cranial    survival    supervisors    hypothesized    shown    behaviours    epithelial    developmental    differential    adult    soft    encompassing    transferable    variety    proliferation    nothing    regulated    structures    influences    recognised    defects    signals    transcriptional    skills    regulation    odontoblasts    multipotent    adjacent    mechano    embryonic    migration    skill    tissue    head    whilst    mesenchymal    generation    stiff    understand    neural    mentored    glia    cell    yap    matrices    give    taz    skeleton    co    osteoblasts    cells    hard    experts    engineering    similarly    neuronal   

Project "CREST UNDER TENSION" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  0000-00-00

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

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 Project objective

Neural crest cells (NCC) are a unique vertebrate-specific population of multipotent cells that contribute to the development and evolution of the vertebrate head. During embryonic development, cranial NCC give rise to a variety of hard and soft tissue cells including osteoblasts, chondrocytes, odontoblasts, glia and neuronal cells. Whilst we understand a great deal about how growth factors and soluble chemicals determine the generation, migration, proliferation, survival and differentiation of the neural crest, nothing is known about how mechano-regulatory factors influence NCC fate. Recent evidence has shown that mesenchymal stem cell fate and cell behaviours are controlled by mechano-regulatory signals via the actinomyosin skeleton, and the co-transcriptional effectors, Yap and Taz. Given that NCC are similarly exposed to different mechanoregulatory influences from stiff and soft matrices and tensions generated by the differential growth and morphogenesis of adjacent epithelial and mesenchymal structures, it is hypothesized that NCC differentiation is also mechano-regulated. This proposal will use in vitro and in vivo approaches to test this hypothesis and determine if NCC fate is governed by mechano-regulatory signals, the differential regulation of the actinomyosin skeleton and Yap/Taz. The proposal will provide novel insight into the mechanisms of embryonic cell differentiation and craniofacial birth defects. Additionally, as neural crest stem cells have been identified in the adult, it will provide an understanding of how these may be manipulated to generate specific cell populations for tissue repair. The proposal will test a novel hypothesis and provide research training in a unique interdisciplinary skill set encompassing biology and engineering at the forefront of research field in addition to transferable skills. The Fellow will be mentored by two internationally recognised supervisors, who are experts in developmental biology and engineering.

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