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EVIDENT

Ebola Virus Disease - correlates of protection, determinants of outcome, and clinical management

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EVIDENT project word cloud

Explore the words cloud of the EVIDENT project. It provides you a very rough idea of what is the project "EVIDENT" about.

africa scientifically fluids cell pathophysiological bsl term health co infer patients shedding building combat fatality immunotherapeutic immunology mid facilities ebola strategies treatment epidemic disease pathogenic efficient efficacy 2014 infectiousness determinants envisaged body collected contributes estimate west rate supportive workers competent experimental plasma protecting ebov evd cooperation convalescent vaccines protection march biosafety transmission correlates suitability infrastructure epidemics toolkit gather biomarkers genomes evident infections hospital viruses virulence reducing communities pan stages mutations monitoring estimation area immunological virus relevance outbreak agents evolution specimens preparedness care

Project "EVIDENT" data sheet

The following table provides information about the project.

Coordinator	BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN Organization address address: BERNHARD NOCHT STRASSE 74 city: HAMBURG postcode: 20359 website: www.bni.uni-hamburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.evident-project.eu
Total cost	1˙759˙325 €
EC max contribution	1˙759˙325 € (100%)
Programme	1. H2020-EU.3.1. (SOCIETAL CHALLENGES - Health, demographic change and well-being)
Code Call	H2020-Adhoc-2014-20
Funding Scheme	RIA
Starting year	2014
Duration (year-month-day)	from 2014-11-01 to 2016-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN Organization address address: BERNHARD NOCHT STRASSE 74 city: HAMBURG postcode: 20359 website: www.bni.uni-hamburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HAMBURG)	coordinator	481˙660.00
2	Department of Health Department of Health Organization address address: Quarry House, Quarry Hill city: Leeds postcode: LS2 7UE website: www.dh.gov.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Leeds)	participant	406˙943.00
3	ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO Organization address address: Via Portuense, 292 city: ROMA postcode: 149 website: www.inmi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	226˙465.00
4	EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH Organization address address: HEINRICH-HERTZ-ALLEE 1 city: ST INGBERT postcode: 66386 website: www.eurice.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ST INGBERT)	participant	163˙375.00
5	BUNDESMINISTERIUM DER VERTEIDIGUNG BUNDESMINISTERIUM DER VERTEIDIGUNG Organization address address: FONTAINENGRABEN 150 city: BONN postcode: 53123 website: http://www.bmvg.de/portal/a/bmvg contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BONN)	participant	73˙625.00
6	PHILIPPS UNIVERSITAET MARBURG PHILIPPS UNIVERSITAET MARBURG Organization address address: BIEGENSTRASSE 10 city: MARBURG postcode: 35037 website: www.uni-marburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MARBURG)	participant	73˙625.00
7	ROBERT KOCH-INSTITUT ROBERT KOCH-INSTITUT Organization address address: Nordufer 20 city: Berlin postcode: 13353 website: www.rki.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Berlin)	participant	73˙437.00
8	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	73˙193.00
9	ORSZAGOS EPIDEMIOLOGIAI KOZPONT ORSZAGOS EPIDEMIOLOGIAI KOZPONT Organization address address: ALBERT FLORIAN UTCA 2-6 city: BUDAPEST postcode: 1097 website: www.oek.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (BUDAPEST)	participant	72˙500.00
10	UNIVERZA V LJUBLJANI UNIVERZA V LJUBLJANI Organization address address: KONGRESNI TRG 12 city: LJUBLJANA postcode: 1000 website: http://www.uni-lj.si contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SI (LJUBLJANA)	participant	72˙000.00
11	ARTSEN ZONDER GRENZEN (MEDECINS SANS FRONTIERES NEDERLAND) VERENIGING ARTSEN ZONDER GRENZEN (MEDECINS SANS FRONTIERES NEDERLAND) VERENIGING Organization address address: PLANTAGE MIDDENLAAN 14 city: Amsterdam postcode: 1018 DD website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Amsterdam)	participant	42˙500.00

Map

Project objective

The Ebola virus disease (EVD) epidemic in West Africa is not under control. This proposal has immediate, mid-term and long-term objectives to combat the current and future EVD epidemics. Objectives with immediate impact are: (i) Providing key information needed to implement efficient convalescent plasma treatment and a toolkit to determine the suitability of plasma for treatment; (ii) Providing key information needed to estimate the efficacy of experimental vaccines, including correlates of protection at T cell level; (iii) Improving supportive treatment of patients and reducing hospital case fatality rate by providing information on biomarkers and relevant co-infections; (iv) Monitoring development of mutations in Ebola virus (EBOV) genomes during the epidemic and enhancing our preparedness to determine the relevance of these changes in experimental systems; and (v) Protecting health care workers and communities by providing information on virus shedding in body fluids and estimation of infectiousness in various stages of EVD. Objectives with mid to long-term impact are: (i) Provide information on pathophysiological changes and immunological determinants to infer new immunotherapeutic strategies for treatment of EVD; and (ii) Strengthening cooperation of biosafety level 4 (BSL-4) facilities and building a pan-European research area in the field of highly pathogenic viruses as envisaged in the ‘European Research Infrastructure on Highly Pathogenic Agents’ project. The concept of EVIDENT is to scientifically exploit specimens collected from EVD patients during outbreak response and field research. We will use state-of-the-art methodologies within the EU BSL-4 facilities to gather new and outbreak-relevant knowledge on B and T cell immunology, biomarkers, virus evolution, virulence determinants, and transmission of EBOV. The consortium contributes to the outbreak response since March 2014 and is competent to implement a project in the outbreak area.

Deliverables

List of deliverables.
External project website	Websites, patent fillings, videos etc.	2019-07-25 12:47:38

Take a look to the deliverables list in detail: detailed list of EVIDENT deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2015	Vincent Madelain, Lisa Oestereich, Frederik Graw, Thi Huyen Tram Nguyen, Xavier de Lamballerie, France MentrÃ©, Stephan GÃ¼nther, Jeremie Guedj Ebola virus dynamics in mice treated with favipiravir published pages: 70-77, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2015.08.015	Antiviral Research 123	2019-07-25
2016	Erik Dietzel, Gordian Schudt, Verena KrÃ¤hling, Mikhail Matrosovich, Stephan Becker Functional characterization of adaptive mutations during the West African Ebola virus outbreak published pages: JVI.01913-16, ISSN: 0022-538X, DOI: 10.1128/JVI.01913-16	Journal of Virology	2019-07-25
2016	SÃ©verine Caluwaerts, Tessy Fautsch, Daphne Lagrou, Michel Moreau, Alseny Modet Camara, Stephan GÃ¼nther, Antonino Di Caro, Benny Borremans, Fara Raymond Koundouno, Joseph Akoi Bore, Christopher H. Logue, Martin Richter, Roman WÃ¶lfel, Eeva Kuisma, Andreas Kurth, Stephen Thomas, Gillian Burkhardt, Elin Erland, Fanshen Lionetto, Patricia Lledo Weber, Olimpia de la Rosa, Hassan Macpherson, Michel Va Dilemmas in Managing Pregnant Women With Ebola: 2 Case Reports: Table 1. published pages: 903-905, ISSN: 1058-4838, DOI: 10.1093/cid/civ1024	Clinical Infectious Diseases 62/7	2019-07-25
2016	Joshua Quick, Nicholas J. Loman, Sophie Duraffour, Jared T. Simpson, Ettore Severi, Lauren Cowley, Joseph Akoi Bore, Raymond Koundouno, Gytis Dudas, Amy Mikhail, Nobila OuÃ©draogo, Babak Afrough, Amadou Bah, Jonathan H. J. Baum, Beate Becker-Ziaja, Jan Peter Boettcher, Mar Cabeza-Cabrerizo, Ãlvaro Camino-SÃ¡nchez, Lisa L. Carter, Juliane Doerrbecker, Theresa Enkirch, Isabel GarcÃa- Dorival, Nico Real-time, portable genome sequencing for Ebola surveillance published pages: 228-232, ISSN: 0028-0836, DOI: 10.1038/nature16996	Nature 530/7589	2019-07-25
2016	Toni Rieger, Romy Kerber, Hussein El Halas, Elisa Pallasch, Sophie Duraffour, Stephan GÃ¼nther, Stephan Ã–lschlÃ¤ger Evaluation of RealStar Reverse Transcriptionâ€“Polymerase Chain Reaction Kits for Filovirus Detection in the Laboratory and Field published pages: S243-S249, ISSN: 0022-1899, DOI: 10.1093/infdis/jiw246	Journal of Infectious Diseases 214/suppl 3	2019-07-25
2016	Paula Ruibal, Lisa Oestereich, Anja LÃ¼dtke, Beate Becker-Ziaja, David M. Wozniak, Romy Kerber, MiÅ¡a Korva, Mar Cabeza-Cabrerizo, Joseph A. Bore, Fara Raymond Koundouno, Sophie Duraffour, Romy Weller, Anja Thorenz, Eleonora Cimini, Domenico Viola, Chiara Agrati, Johanna Repits, Babak Afrough, Lauren A. Cowley, Didier Ngabo, Julia Hinzmann, Marc Mertens, InÃªs Vitoriano, Christopher H. Logue, Jan Unique human immune signature of Ebola virus disease in Guinea published pages: 100-104, ISSN: 0028-0836, DOI: 10.1038/nature17949	Nature 533/7601	2019-07-25
2016	Boubacar Diallo, Daouda Sissoko, Nicholas J. Loman, Hadja AÃ¯ssatou Bah, Hawa Bah, Mary Claire Worrell, lya Saidou Conde, Ramata Sacko, Samuel Mesfin, Angelo Loua, Jacques Katomba Kalonda, Ngozi A. Erondu, Benjamin A. Dahl, Susann Handrick, Ian Goodfellow, Luke W. Meredith, Matthew Cotten, Umaru Jah, Raoul Emeric Guetiya Wadoum, Pierre Rollin, N\'Faly Magassouba, Denis Malvy, Xavier Anglaret, Miles Resurgence of Ebola Virus Disease in Guinea Linked to a Survivor With Virus Persistence in Seminal Fluid for More Than 500 Days published pages: 1353-1356, ISSN: 1058-4838, DOI: 10.1093/cid/ciw601	Clinical Infectious Diseases 63/10	2019-07-25
2016	Verena KrÃ¤hling, Dirk Becker, Cornelius Rohde, Markus Eickmann, Yonca EroÄŸlu, Astrid Herwig, Romy Kerber, Katharina Kowalski, JÃºlia Vergara-Alert, Stephan Becker Development of an antibody capture ELISA using inactivated Ebola Zaire Makona virus published pages: 173-183, ISSN: 0300-8584, DOI: 10.1007/s00430-015-0438-6	Medical Microbiology and Immunology 205/2	2019-07-25
2016	Daouda Sissoko, Cedric Laouenan, Elin Folkesson, Abdoul-Bing Mâ€™Lebing, Abdoul-Habib Beavogui, Sylvain Baize, Alseny-Modet Camara, Piet Maes, Susan Shepherd, Christine Danel, Sara Carazo, Mamoudou N. Conde, Jean-Luc Gala, GÃ©raldine Colin, HÃ©lÃ¨ne Savini, Joseph Akoi Bore, Frederic Le Marcis, Fara Raymond Koundouno, FrÃ©dÃ©ric Petitjean, Marie-Claire Lamah, Sandra Diederich, Alexis Tounkara, Gee Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea published pages: e1001967, ISSN: 1549-1676, DOI: 10.1371/journal.pmed.1001967	PLOS Medicine 13/3	2019-07-25
2016	C Agrati, C Castilletti, R Casetti, A Sacchi, L Falasca, F Turchi, N Tumino, V Bordoni, E Cimini, D Viola, E Lalle, L Bordi, S Lanini, F Martini, E Nicastri, N Petrosillo, V Puro, M Piacentini, A Di Caro, G P Kobinger, A Zumla, G Ippolito, M R Capobianchi Longitudinal characterization of dysfunctional T cell-activation during human acute Ebola infection published pages: e2164, ISSN: 2041-4889, DOI: 10.1038/cddis.2016.55	Cell Death and Disease 7/3	2019-07-25
2016	Romy Kerber, Ralf Krumkamp, Boubacar Diallo, Anna Jaeger, Martin Rudolf, Simone Lanini, Joseph Akoi Bore, Fara Raymond Koundouno, Beate Becker-Ziaja, Erna Fleischmann, Kilian Stoecker, Silvia Meschi, StÃ©phane MÃ©ly, Edmund N. C. Newman, Fabrizio Carletti, Jasmine Portmann, Misa Korva, Svenja Wolff, Peter Molkenthin, Zoltan Kis, Anne Kelterbaum, Anne Bocquin, Thomas Strecker, Alexandra Fizet, Conc Analysis of Diagnostic Findings From the European Mobile Laboratory in GuÃ©ckÃ©dou, Guinea, March 2014 Through March 2015 published pages: S250-S257, ISSN: 0022-1899, DOI: 10.1093/infdis/jiw269	Journal of Infectious Diseases 214/suppl 3	2019-07-25
2016	Anja LÃ¼dtke, Paula Ruibal, Beate Becker-Ziaja, Monika Rottstegge, David M. Wozniak, Mar Cabeza-Cabrerizo, Anja Thorenz, Romy Weller, Romy Kerber, Juliana Idoyaga, N\'Faly Magassouba, Martin Gabriel, Stephan GÃ¼nther, Lisa Oestereich, CÃ©sar MuÃ±oz-Fontela Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16 + Monocytes published pages: S275-S280, ISSN: 0022-1899, DOI: 10.1093/infdis/jiw260	Journal of Infectious Diseases 214/suppl 3	2019-07-25
2015	Thomas Strecker, Bernadett Palyi, Heinz Ellerbrok, Sylvie Jonckheere, Hilde de Clerck, Joseph Akoi Bore, Martin Gabriel, Kilian Stoecker, Markus Eickmann, Michel van Herp, Pierre Formenty, Antonino Di Caro, Stephan Becker Field Evaluation of Capillary Blood Samples as a Collection Specimen for the Rapid Diagnosis of Ebola Virus Infection During an Outbreak Emergency published pages: 669-675, ISSN: 1058-4838, DOI: 10.1093/cid/civ397	Clinical Infectious Diseases 61/5	2019-07-25
2015	Miles W. Carroll, David A. Matthews, Julian A. Hiscox, Michael J. Elmore, Georgios Pollakis, Andrew Rambaut, Roger Hewson, Isabel GarcÃa-Dorival, Joseph Akoi Bore, Raymond Koundouno, SaÃ¯d Abdellati, Babak Afrough, John Aiyepada, Patience Akhilomen, Danny Asogun, Barry Atkinson, Marlis Badusche, Amadou Bah, Simon Bate, Jan Baumann, Dirk Becker, Beate Becker-Ziaja, Anne Bocquin, Benny Borremans, A Temporal and spatial analysis of the 2014â€“2015 Ebola virus outbreak in West Africa published pages: 97-101, ISSN: 0028-0836, DOI: 10.1038/nature14594	Nature 524/7563	2019-07-25

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