Opendata, web and dolomites
H2020 projects about "mutations"
The page lists 391 projects related to the topic "mutations".
| # | |||
|---|---|---|---|
| 1 | PRO-CF-MED | Clinical Proof of concept for a RNA-targeting Oligonucleotide for a Cystic fibrosis-F508del MEDication | 2015 |
| 2 | Ageing with elegans | Validating C. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies. | 2015 |
| 3 | APERIM | APERIM: Advanced bioinformatics platform for PERsonalised cancer IMmunotherapy | 2015 |
| 4 | GermAge | The aging germ cell – biological pathways, risk factors and mechanisms underlying an increasing medical and socio-economic problem | 2015 |
| 5 | BeyondSeq | Genomic diagnostics beyond the sequence | 2015 |
| 6 | PanCanRisk | Personalized bioinformatics for global cancer susceptibility identification and clinical management | 2015 |
| 7 | RevMito | Deciphering and reversing the consequences of mitochondrial DNA damage | 2015 |
| 8 | BREATHE | Biochemically modified messenger RNA encoding nucleases for in vivo gene correction of severe inherited lung diseases | 2015 |
| 9 | CrIC | Molecular basis of the cross-talk between chronic inflammation and cancer | 2015 |
| 10 | STARLIGHT | Steering attosecond electron dynamics in biomolecules with UV-XUV LIGHT pulses | 2015 |
| 11 | PredicTOOL | Nanomethods to understand what makes an endogenous protein immunogenic | 2015 |
| 12 | CRCStemCellDynamics | Molecular Subtype Specific Stem Cell Dynamics in Developing and Established Colorectal Cancers | 2015 |
| 13 | PhosFunc | Dissecting the functional importance of eukaryotic protein phosphorylation | 2015 |
| 14 | LimitMDR | Utilizing evolutionary interactions to limit multidrug resistance | 2015 |
| 15 | G4DSB | G-quadruplex DNA Structures and Genome Stability | 2015 |
| 16 | REMEMBER | Adaptive immunity in prokaryotes: how Bacteria do not forgive and do not forget their enemies | 2015 |
| 17 | eDrug | Drug eDesign: Building the next generation of software solutions for drug design | 2015 |
| 18 | ECMED | The Extracellular Matrix in Epileptogenesis | 2015 |
| 19 | RNArepair | Site-directed RNA Editing to Manipulate RNA and Protein Function | 2015 |
| 20 | MitSyn | Alpha-synuclein and mitochondrial dysfunction: key links between Gaucher’s disease and Parkinson’s? | 2015 |
| 21 | Cancer-Drug-Screen | High-throughput drug screening for identifying personalized cancer treatments tailored to the particular mutations of the patient’s tumor | 2015 |
| 22 | MITONUC | The evolutionary and ecological implications of mito-nuclear epistasis | 2015 |
| 23 | GUTWORM | Unravelling host intestine-parasite interactions that define immune responses to whipworms | 2015 |
| 24 | RAGES | Molecular determination of Rif1-Associated Genomic Elements and their function in regulating genome activity and integrity | 2016 |
| 25 | LQTS-HORSES | Platform for diagnosing long QT syndrome in horses - Step II: Identification of long QT syndrome | 2015 |
| 26 | NeuroUTR | Systematic investigation of the functional coupling between transcriptional and post-transcriptional regulatory interactions underlying tissue-specific 3'UTRs variability. | 2015 |
| 27 | MaSCheNav | Mass Spectrometry-Based Chemoproteomic Profiling of Nav1.7, a Voltage-Gated Sodium Channel | 2015 |
| 28 | HGSOC | A novel approach into modeling origin and development of ovarian cancer | 2015 |
| 29 | MELANOPARK | Investigating the LRRK2-melanin connection through phosphoproteomics of isogenic melanoma cells | 2015 |
| 30 | AND | Antibacterial (Nano)medicines Development | 2015 |
| 31 | NovLeuReg | Identification and characterization of novel essential regulators of acute myeloid leukemia | 2016 |
| 32 | [e-POM-Bioanal] | Electrobioanalytical Applications of Polyoxometalates | 2015 |
| 33 | FCSM | Human myosins | 2015 |
| 34 | SorCSbalance | Role of the sorting receptor SorCS1 in controlling excitation/inhibition balance in neural circuits. | 2015 |
| 35 | EpiLIVER | Characterization and implications of DNA damage response in liver cancer | 2016 |
| 36 | SFSASP | Structural and Functional Studies of ATRX- Syndrome Protein | 2015 |
| 37 | HAAIV | Adaptive evolutionary pathways of highly pathogenic avian H5N1 influenza in humans | 2015 |
| 38 | ParaplegiaERDros | Roles of spastic paraplegia proteins in organisation of axonal endoplasmic reticulum | 2016 |
| 39 | APOBEC | Enzymatic DNA deamination and the immunity/cancer balance | 2015 |
| 40 | WntTraffic | Characterising the spatial organisation and regulation of the Wnt receptor complex in stem cells and cancer | 2016 |
| 41 | RLOOP-AS | Interconnection between R-loops and co-transcriptional alternative splicing | 2015 |
| 42 | BRCA2Interact | Structural and biochemical characterization of pre-recombination complexes | 2015 |
| 43 | HepatoRiSK | A new tumor suppressor role for RSK2 in hepatocellular carcinoma | 2015 |
| 44 | NMJALS | In vivo analysis of neuromuscular junction stability in zebrafish models of amyotrophic lateral sclerosis | 2015 |
| 45 | SOX10mutants | Investigating genotype-phenotype correlations in SOX10 neurocristopathies | 2015 |
| 46 | EVIDENT | Ebola Virus Disease - correlates of protection, determinants of outcome, and clinical management | 2014 |
| 47 | FGFSTAB | Industrial Production of Stable Fibroblast Growth Factors for Broad Therapeutic, Research, and Personal Care Applications | 2015 |
| 48 | ComplEvol | Evolutionary origins of complex ecological adaptations | 2015 |
| 49 | ER_disease | Defining hormonal cross-talk and the role of mutations in estrogen receptor positive breast cancer | 2015 |
| 50 | PNANOMED | Personalized Nanomedicines for Leukemia Patients | 2015 |
| 51 | SPICE | Synthetic Lethal Phenotype Identification through Cancer Evolution Analysis | 2015 |
| 52 | RegulHox | Topological organization of vertebrate regulatory landscapes: The Hox genes paradigm | 2015 |
| 53 | MetAGEn | Metabolic and Genetic Regulation of Ageing | 2015 |
| 54 | MolCellTissMech | Molecular and cellular determinants of cell monolayer mechanics | 2015 |
| 55 | COMAL | COMAL:COhesin Mutations in Acute Leukemia: from modeling and mechanisms to novel therapeutics | 2015 |
| 56 | AdaptoSCOPE | Using cis-regulatory mutations to highlight polygenic adaptation in natural plant systems | 2015 |
| 57 | DNA2REPAIR | DNA strand break repair and links to human disease | 2015 |
| 58 | SHUFFLE | Recombination in large genome crop plants | 2015 |
| 59 | IL7sigNETure | IL-7/IL-7R signaling networks in health and malignancy | 2015 |
| 60 | Oligomers | Characterising protein oligomers and their role in neurodegenerative disease in humans | 2015 |
| 61 | PROTEOMICS4D | Proteomics 4D: The proteome in context | 2015 |
| 62 | STEMCARDIORISK | Stem Cells for Cardiac Arrhythmia Risk Assessment | 2015 |
| 63 | M-Imm | Novel etiology of autoimmune disorders: the role of acquired somatic mutations in lymphoid cells | 2015 |
| 64 | MASCP | Mechanisms of alternative pre-mRNA splicing regulation in cancer and pluripotent cells | 2015 |
| 65 | SYSMET | Systems Biology of Membrane Trafficking | 2016 |
| 66 | BROADimmune | Structural, genetic and functional analyses of broadly neutralizing antibodies against human pathogens | 2015 |
| 67 | PRION2020 | Function and malfunction of the prion protein | 2015 |
| 68 | COMbAT | Commercialization of a novel tool for designing personalized nOvel MelAnoma Therapies | 2015 |
| 69 | SLACC | Supplying lung adenocarcinoma cell lines to the cancer research community. | 2015 |
| 70 | AcTafactors | AcTafactors: Tumor Necrosis Factor-based immuno-cytokines with superior therapeutic indexes | 2015 |
| 71 | BioBarPro | A Hot-Spot Bio-Barcode Strategy for Prognostic Biomarkers In Colorectal Cancer | 2015 |
| 72 | TrainMALTA | Interdisciplinary Training in High-Throughput Sequencing, Bioinformatics and Model Systems: Moving towards Clinical applications of Genomics | 2016 |
| 73 | PhotoMutant | Rational Design of Photoreceptor Mutants with Desired Photochemical Properties | 2016 |
| 74 | CRISPAIR | Study of the interplay between CRISPR interference and DNA repair pathways towards the development of novel CRISPR tools | 2016 |
| 75 | DROSADAPTATION | New approaches to long-standing questions: adaptation in Drosophila | 2016 |
| 76 | HemAcure | Application of combined gene and cell therapy within an implantable therapeutic device for the treatment of severe hemophilia A | 2015 |
| 77 | EvoGenMed | Evolutionary genomics: new perspectives and novel medical applications | 2016 |
| 78 | Liqbiopsens | Reliable Novel Liquid Biopsy technology for early detection of colorectal cancer | 2016 |
| 79 | NetMoDEzyme | Network models for the computational design of proficient enzymes | 2016 |
| 80 | SATBIOFUN | Genome editing for spatiotemporal analysis of centriolar SATellite BIOgenesis and FUNction in cellular stress responses | 2016 |
| 81 | COSI | Cerebellar modules and the Ontogeny of Sensorimotor Integration | 2016 |
| 82 | iGEMMdev | Development and Characterisation of New Immunogenic GEMMs of Lung Cancer | 2017 |
| 83 | SLIM | Synthetic Lethal Interactions with nucleophosMin 1 | 2016 |
| 84 | RecInRep | Beyond double-strand break repair: specific mechanisms of homologous recombination at stressed replication forks. | 2016 |
| 85 | INTEGRISTEM | Functions of Integrins in Mammary Stem Cell Activity and Tumorigenesis | 2016 |
| 86 | DNA Pol III | How single DNA polymerases make decisions during proofreading | 2016 |
| 87 | MPSC | Membrane Potential and Stem Cell Potency in Normal and Malignant Tissues | 2016 |
| 88 | ROQ-WACh | Identification and Characterization of Cis-Regulatory ModuleDysfunction in Rett Syndrome with ROQ-WACh | 2016 |
| 89 | ZPR | The Pancreas Regulome: From causality to prediction of non-coding mutations in human pancreatic diseases | 2016 |
| 90 | SYNVIA | Synthetic viability of homologous recombination-deficient cancers | 2016 |
| 91 | Tolerome | Evolution of antibiotic tolerance in the 'wild': A quantitative approach | 2016 |
| 92 | TSGPs-of-CFSs | Role of Tumour Suppressor Gene Products of Common Fragile Sites in Human Diseases | 2016 |
| 93 | DELMIT | Maintaining the Human Mitochondrial Genome | 2016 |
| 94 | EvolVir | Evolution of virulence in immune-compromised hosts and the adaptation of emerging viruses | 2017 |
| 95 | Wnt and CRC | Therapeutic inhibition of the oncogenic Wnt/beta-catenin pathway in mismatch repair deficient hypermutant tumors | 2017 |
| 96 | CF_struct | High-Resolution X-ray Structures of Full-Length Cystic Fibrosis Transmembrane Conductance Regulator | 2016 |
| 97 | MITOBIOPATH | DISCOVERING NEW DISEASE PATHWAYS AFFECTING mtDNA METABOLISM | 2016 |
| 98 | EpiHope | Epigenetic biomarkers for prediction of vascular complications and response to treatment in subjects with diabetes | 2016 |
| 99 | 2MoveMate4Melanoma | A treatment for BRAF inhibitor resistant melanoma | 2016 |
| 100 | CentSatRegFunc | Dissecting the function and regulation of centriolar satellites: key regulators of the centrosome/cilium complex | 2016 |
| 101 | ICLUb | Regulation of DNA interstrand crosslink repair by ubiquitin. | 2016 |
| 102 | DENOVOMUT | An integrated approach to understanding the impact of de novo mutations on the mammalian genome | 2017 |
| 103 | REPROHEAT | Increasing reproductive success in crops under high ambient temperature | 2017 |
| 104 | EpiTarget | Epigenome-targeted therapy for cholangiocarcinoma. | 2017 |
| 105 | DMD2CURE | Correction of duplications in the DMD gene by a CRISPR/Cas9 approach | 2017 |
| 106 | SPLICE3D | CryoEM studies of the spliceosome | 2016 |
| 107 | PCFENCM | Pan-cancer functional evaluation of non-coding DNA mutations | 2017 |
| 108 | REVOLINC | Revolutionizing Insect Control | 2016 |
| 109 | GeCo | Data-Driven Genomic Computing | 2016 |
| 110 | CDK6-DrugOpp | CDK6 in transcription - turning a foe in a friend | 2016 |
| 111 | ZMOD | Blood Vessel Development and Homeostasis: Identification and Functional Analysis of Genetic Modifiers | 2016 |
| 112 | GUPPYSEX | Evolutionary genetics of guppy sex chromosomes | 2016 |
| 113 | SYNNOVATE | Molecular organization and dynamics of synapse diversity: novel genetic, imaging and computational approaches | 2016 |
| 114 | PicoCB | Exploring the Chemical Biology of Sequence Space via Picoliter Droplets | 2016 |
| 115 | MARS | Mechanism of allosteric regulation of SHP2 phosphatase and its role in cancer and geneticdiseases: a multidisciplinary computational, structural and biological approach | 2017 |
| 116 | CANDICE | CEREBRAL ASYMMETRY: NEW DIRECTIONS IN CORRELATES AND ETIOLOGY | 2016 |
| 117 | EYEGET | Gene therapy of inherited retinal diseases | 2017 |
| 118 | TRANSREAD | Restoration of tumor suppressor function by induction of translational read-through of premature termination codons - a strategy for improved cancer therapy | 2016 |
| 119 | ProCovar | Exploring new applications of amino acid covariation analysis in modelling proteins and their complexes | 2016 |
| 120 | TRANSMIT | TRANSlating the role of Mitochondria in Tumorigenesis | 2017 |
| 121 | SYNTRAIN | Targeting SYNthetic lethal interactions for new cancer treatments TRAINing network | 2016 |
| 122 | REMIX | Regulation of mitochondrial expression | 2016 |
| 123 | 1toStopVax | RNA virus attenuation by altering mutational robustness | 2016 |
| 124 | FMF-Dia | Immunological Diagnosis of Familial Mediterranean Fever | 2016 |
| 125 | CohesinMolMech | Molecular mechanisms of cohesin-mediated sister chromatid cohesion and chromatin organization | 2016 |
| 126 | NOMBIS | Nano-OptoMechanical Systems for Biological Sensors | 2016 |
| 127 | EPITOR | NEUROBIOLOGY OF EPILEPSY GENES | 2016 |
| 128 | SPLICECODE | Alternative Splicing Codes for Synaptic Specificity | 2016 |
| 129 | VIRUSCAN | Optomechanics for Virology | 2016 |
| 130 | SexAntag | Prevalence and Influence of Sexual Antagonism on Genome Evolution | 2017 |
| 131 | RTEL1inHHS | Characterization of RTEL1 mutations in Hoyeraal-Hreidarsson Syndrome | 2017 |
| 132 | PAPA | Pathophysiology of Primary Aldosteronism | 2017 |
| 133 | THERACAN | Novel therapeutic strategies to treat pancreatic and lung cancer | 2017 |
| 134 | PHENOSPACE | Quantifying behavioural phenotype space: chemistry-to-gene screens and combination therapies | 2016 |
| 135 | DiVineGenoMe | Decoding cell-to-cell variation in genome integrity maintenance | 2017 |
| 136 | NONCODRIVERS | Finding noncoding cancer drivers | 2016 |
| 137 | ALS-Networks | Defining functional networks of genetic causes for ALS and related neurodegenerative disorders | 2017 |
| 138 | IlluMitoDNA | Illuminating the mechanisms of mitochondrial DNA quality control and inheritance | 2017 |
| 139 | iGBMavatars | Glioblastoma Subtype Avatar models for Target Discovery and Biology | 2017 |
| 140 | LungCARD | Blood test for clinical therapy guidance of non-small cell lung cancer patients | 2017 |
| 141 | GENE FOR CURE | Expanding and extending gene therapy of monogenic diseases of the haematopoietic system | 2016 |
| 142 | BONEPHAGY | Defining the role of the FGF – autophagy axis in bone physiology | 2017 |
| 143 | 3D-REPAIR | Spatial organization of DNA repair within the nucleus | 2017 |
| 144 | FANCODRUG | Reactivation of the Fanconi anemia-BRCA pathway in cells carrying patient-derived missense mutations: finding a drug to cure Fanconi anemia | 2017 |
| 145 | ADAPTATION | Predicting adaptive responses of protected species to environmental changes to optimise conservation management frameworks in Europe | 2016 |
| 146 | Reg-Seq | Functional genomics of non-coding mutations in regulatory regions of four metabolic tissues, and their involvement into type 2 diabetes through large-scale sequencing | 2017 |
| 147 | MAMLE | Understanding the mechanisms of human acute myeloid leukaemia (AML) evolution | 2017 |
| 148 | CancerFluxome | Cancer Cellular Metabolism across Space and Time | 2017 |
| 149 | COLGENES | Defining novel mechanisms critical for colorectal tumourigenesis | 2017 |
| 150 | SpecIAnt | Speciation in ants: Unraveling the genetic, epigenetic and molecular basis of speciation using wood ants | 2018 |
| 151 | BRECASTEM | Functional and Molecular Characterisation of Breast Cancer Stem Cells | 2017 |
| 152 | MDRZYMES | Multidrug resistance gene regulators as scaffolds for the design and evolution of artificial metalloenzymes | 2017 |
| 153 | Mitomorphosis | Metabolic regulation of mitochondrial morphology | 2017 |
| 154 | GlycoModels | 3D glyco-engineered models to address the role of glycosylation in gastric cancer clinical management | 2017 |
| 155 | EnzVolNet | COMPUTATIONAL EVOLUTION OF ENZYME VARIANTS THROUGH CONFORMATIONAL NETWORKS | 2017 |
| 156 | ONCOmetENHANCERS | Elucidating the Role of Enhancer Methylation Variation in Cancer and Developing Enhancer-based Markers and Targets for Precision Medicine | 2017 |
| 157 | MultiLevelLandscape | Multilevel Selection for Specificity and Divergence in Bacteria | 2017 |
| 158 | CHROMONUMBER | Chromosome number variations in vivo: probing mechanisms of genesis and elimination | 2017 |
| 159 | CRISP-4-CROPS | CRISPR/Cas9 technology implementation for improved resistance to Abiotic Stress in cereals | 2017 |
| 160 | MuRChap | The mutation-buffering capacity of RNA chaperones | 2017 |
| 161 | SpliceCore | Functional dissection of core spliceosomal mutations causing Retinitis Pigmentosa. | 2017 |
| 162 | ReXeG | Deciphering molecular mechanisms that resolve mutagenic DNA G-quadruplex structures | 2017 |
| 163 | rDNAevol | Population genomics and experimental evolution of ribosomal RNA gene variants in Arabidopsis thaliana | 2017 |
| 164 | PHYSBIOHSC | Understanding the physical biology of adult blood stem cells | 2017 |
| 165 | REACT | Uncovering the role of cis genetic elements in antigenic variation of Plasmodium falciparum using the CRISPR-Cas9 genome editing technology | 2018 |
| 166 | ResistEpist | Dissection of the mechanisms causing the epistasis between antibiotic resistance mutations in Escherichia coli | 2018 |
| 167 | DNAmethAML | Investigation of aberrant DNA methylation in malignant haematopoiesis | 2018 |
| 168 | MSCFate | Fate of mammary stem cells during tumorigenesis and clinical implications | 2017 |
| 169 | PhaseAge | The chemistry and physics of RNP granules: how they form, age and cause disease | 2017 |
| 170 | COTETHERS | Molecular characterization of vesicle tethering complexes as novel regulators of collagen trafficking | 2017 |
| 171 | IVORIaN | RAS/C-RAF interaction: A new pharmacological target in Kras-driven lung cancer. | 2017 |
| 172 | SAMNets | Investigation of adaptive design and rewiring of Survival-Apoptosis-Mitogenic (SAM) signalling transduction network | 2017 |
| 173 | SAS6-Cep135-CPAP | Towards a molecular understanding of the centriole assembly process | 2017 |
| 174 | SPLICANCER | Regulation and reprogramming of alternative splicing in cellular transformation | 2017 |
| 175 | IDRAM | The role of amphidial drug uptake in the mode of action and resistance to ivermectin in nematodes of livestock | 2017 |
| 176 | SAVE | Shear Stress Induced Arterial and Venous Specification through Piezo1 | 2018 |
| 177 | SynPCP | Synapse formation and maturity through planar cell polarity pathway | 2018 |
| 178 | HOST-SELECT | Functional Analysis of Host Genetic Variants: Biomarker Selection Towards Improving Female Subfertility Diagnosis and Treatment | 2017 |
| 179 | CHIROGLU | Comparative genomics of sugar-eating bats: Implications for the genetics of glucose metabolism and diabetes | 2017 |
| 180 | GeneVision | Developing a cure for retinitis pigmentosa due to Usher syndrome | 2017 |
| 181 | ContraNPM1AML | Dissecting to hit the therapeutic targets in nucleophosmin (NPM1)-mutated acute myeloid leukemia | 2017 |
| 182 | MITOQUAD | Unveiling the mitochondrial role of DNA2, a human helicase-nuclease causing mtDNA deletion associated syndrome. | 2018 |
| 183 | Signalling-in-NODs | Investigation of the role and mechanism of action of NOD2-mediated isoform selective PI3K signalling in gut immunity and inflammation | 2017 |
| 184 | BaskAtax | Modulation of Basket cell microcircuits in cerebellar cortex paroxysmal ataxia disorders | 2017 |
| 185 | AS-CELLEXPAND | Role of alternative splicing in cell expansion and plant growth | 2018 |
| 186 | CFZEBRA | Balancing the immune response in cystic fibrosis: using zebrafish models of infection and inflammation to uncover new therapeutic approaches | 2017 |
| 187 | BLASTOFF | Retooling plant immunity for resistance to blast fungi | 2017 |
| 188 | cis-CONTROL | Decoding and controlling cell-state switching: A bottom-up approach based on enhancer logic | 2017 |
| 189 | RESPEC | Reconstruction of Pollinator-Mediated Speciation by Identification and Substitution of Causative Mutations | 2017 |
| 190 | ReCAP | Repair capacity and genome diversity in mammals | 2017 |
| 191 | DissectPcG | Dissecting the Function of Multiple Polycomb Group Complexes in Establishing Transcriptional Identity | 2017 |
| 192 | CATCH-U-DNA | Capturing non-Amplified Tumor Circulating DNA with Ultrasound Hydrodynamics | 2017 |
| 193 | NoiseRobustEvo | Noise and robustness in the evolution of novel protein phenotypes | 2017 |
| 194 | mtDNA-CURE | Treating mitochondrial disease caused by pathogenic mtDNA mutations | 2018 |
| 195 | GENSURGE | Designer recombinases for efficient and safe genome surgery | 2018 |
| 196 | BRCA-ERC | Understanding cancer development in BRCA 1/2 mutation carriers for improved Early detection and Risk Control | 2017 |
| 197 | INTACt | ImmuNogenomics TArgeting Cancer | 2017 |
| 198 | MCircuits | Connectivity, plasticity and function of an olfactory memory circuit | 2017 |
| 199 | TelMetab | Telomere metabolism in Genome Stability and Disease | 2017 |
| 200 | V-EPC | Inherited disfunctions of brain microcirculation | 2017 |
| 201 | LUPUSCARE | PRECISION CARE IN SYSTEMIC AUTOIMMUNITY: AN INTEGRATED MULTI-TISSUE/LEVEL APPROACH FOR SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) | 2017 |
| 202 | onCOMBINE | Towards evidence-based combinations of approved and novel cancer drugs | 2017 |
| 203 | HYPER-INSIGHT | Hypermutated tumors: insight into genome maintenance and cancer vulnerabilities provided by an extreme burden of somatic mutations | 2018 |
| 204 | MULTIEPIGEN | Ancestral environmental exposures and offspring health – a multigenerational epidemiologic cohort study across 3 generations | 2017 |
| 205 | REVERSEAUTISM | Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models | 2017 |
| 206 | TREAT-NPM1-AML | Improving therapy of NPM1-mutated AML | 2017 |
| 207 | SUGARSmart | SUGARSmart: Smart design of recombinant antibody fragments specific for carbohydrate molecules | 2018 |
| 208 | TTNPred | Development of novel computational biology pipeline for the efficient classification of titin SNPs for clinical use | 2018 |
| 209 | CRISS | CRISPR Gene Correction for Severe Combined Immunodeficiency Caused by Mutations in Recombination-activating gene 1 and 2 (RAG1 and RAG2) | 2017 |
| 210 | MisloQC | Dissecting Quality Control Mechanisms of Mislocalized Proteins | 2018 |
| 211 | SynapseER | Endoplasmic reticulum structure and synaptic function in Drosophila | 2018 |
| 212 | ORI NUMBER | Unravelling the effect of origin number on the success of genome replication | 2017 |
| 213 | UshTher | Clinical trial of gene therapy with dual AAV vectors for retinitis pigmentosa in patients with Usher syndrome type IB | 2018 |
| 214 | MCDS-Therapy | Repurposing of carbamazepine for treatment of skeletal dysplasia | 2017 |
| 215 | COLOSSUS | Advancing a Precision Medicine Paradigm in metastatic Colorectal Cancer: Systems based patient stratification solutions | 2018 |
| 216 | HIT-CF | Personalised Treatment For Cystic Fibrosis Patients With Ultra-rare CFTR Mutations (and beyond) | 2018 |
| 217 | CureCN | Adeno-Associated Virus Vector-Mediated Liver Gene Therapy for Crigler-Najjar Syndrome | 2018 |
| 218 | INSITUMUT | Direct detection of cancer-causing mutations in tumour specimens | 2018 |
| 219 | LIMA | Liquid biopsies and Imaging for improved cancer care | 2018 |
| 220 | CHIPS | Effects of Prenatal Exposure to Acrylamide on Health: Prospective Biomarker-Based Studies | 2018 |
| 221 | EvoCellBio | A combined in vitro and in vivo approach to dissect biochemical network evolution. | 2018 |
| 222 | AltCheM | In vivo functional screens to decipher mechanisms of stochastically- and mutationally-induced chemoresistance in Acute Myeloid Leukemia | 2018 |
| 223 | EXACT-dna | EXtended Analysis of Circulating Tumour DNA to improve cancer management strategies | 2017 |
| 224 | CMTaaRS | Defective protein translation as a pathogenic mechanism of peripheral neuropathy | 2018 |
| 225 | DiSect | The Tumour Stroma as a Driver of Clonal Selection | 2018 |
| 226 | Emedgene | An ICT decision support system for clinical interpretation of genomic data, used by geneticists to rapidly and accurately pinpoint unique disease-causing variants | 2018 |
| 227 | CROSS-NEUROD | Transferring autonomous and non autonomous cell degeneration 3D models between EU and USA for development of effective therapies for neurodegenerative diseases (ND) | 2018 |
| 228 | LYSOBONE | Cellular and molecular analysis of the skeletal pathologies associated with mucopolysaccharidosis-VI (MPS-VI) | 2018 |
| 229 | TET2rec | Mechanisms of TET2 DNA demethylase recruitment to specific genomic regions | 2018 |
| 230 | ZIDOMS | Using Zebrafish as a novel tool to Improve the Diagnosis and Outcome of Marfan Syndrome | 2018 |
| 231 | SomaGrapeGenome | Fast-forward genomics of somatic variants adaptable to climate change for cultivar innovation in grapevine | 2018 |
| 232 | MaGMa | Applying Metabolomics to Unveil follow-up treatment biomarkers and Identify Novel TherapeuticTargets in Glioblastoma | 2018 |
| 233 | MAPGenome | Mapping migration and adaptation in genomes | 2018 |
| 234 | CL_Exocytosis | “Molecular dissection of cytotoxic lymphocyte exocytosis | 2019 |
| 235 | CXCR4THERAPY | IMPROVING HEMATOPOIETIC STEM CELL- BASED GENE THERAPY OUTCOME BY MODULATING CXCR4 EXPRESSION | 2018 |
| 236 | DNAProteinCrossRep | Identification of DNA-Protein-Crosslink Repair Factors | 2018 |
| 237 | EE-Dynamics | Dynamics of eco-evolutionary systems | 2018 |
| 238 | NoMePaCa | Novel Metabolic Pathways in Cancer | 2018 |
| 239 | EScORIAL | Emerging Simplex ORigins In ALS | 2018 |
| 240 | PhenomeNal | Inheritance, expressivity and epistasis hidden behindthe phenotypic landscape of natural populations | 2018 |
| 241 | MOSAIC | Relationship of Somatic Structural Variation Mosaicism to Aging and Disease Phenotypes | 2019 |
| 242 | HGB-StIC | Human Genetic Basis of Severe Staphylococcal Infections in Childhood | 2019 |
| 243 | PrunMut | Candidate mutation discovery in early-flowering mutants 'Rojo Pasión Precoz' and 'Bulida Precoz' | 2019 |
| 244 | Stress Granules | Using Reconstituted Stress Granules to Gain Insight into the Molecular Pathology of Neurodegenerative Diseases | 2019 |
| 245 | FABA-SHAPE | Unveiling the Origins of the Faba Bean by means of Shape and Stable Carbon Isotope Analyses of Archaeological Remains | 2019 |
| 246 | NaKStruc | Structural studies of Na,K-ATPase isoforms and mutants | 2018 |
| 247 | SHINE | Self-Healthcare for breast cancer detection using an INtegrated paper-based Electrochemical device | 2019 |
| 248 | PPRdesign | Engineering synthetic pentatricopeptide repeat proteins for the site-specific genetic manipulation of plant organelles | 2018 |
| 249 | LEVADAPT | Identification of new regulators of Acetylcholine receptor using the nematode Caenorhabditis elegans | 2018 |
| 250 | OESOPHAGEAL FATE | Epithelial/Mesenchymal Cross-talk in response to injury and early tumorigenesis; a spatiotemporal perspective | 2019 |
| 251 | PREMEDiCARE | PREcision MEDicine with induced pluripotent stem cells for Cardiac Arrhythmias Risk Evaluation | 2018 |
| 252 | LEUKEYOLK | Uncovering the origin and mechanisms of Down syndrome-associated leukaemia through human induced pluripotent stem cell-derived haemopoiesis | 2019 |
| 253 | AvINFLUENZA | Molecular basis of avian influenza polymerase adaptation to human hosts | 2019 |
| 254 | GlycoPCs | How do Pharmacological Chaperones work? Molecular basis of the actions of glycomimetics on keyglycosidases involved in lysosomal storage disorders | 2018 |
| 255 | MITOPOMPE | Targeting mitochondrial defects and oxidative stress in Pompe Disease: from pathogenesis to therapy | 2019 |
| 256 | P-MaleReg | Establishment of P-element silencing in Drosophila simulans dysgenic males | 2019 |
| 257 | ParAdapt | Theoretical and empirical approaches to understanding Parallel Adaptation | 2018 |
| 258 | INFLA-AID | The role of NLRC4 inflammasome in autoinflammatory diseases | 2018 |
| 259 | SZFunc | Functional Analysis of Schizophrenia Risk Gene RBM12 | 2018 |
| 260 | VulneraBAP1 | Mechanism and vulnerability of BAP1 loss in tumor metastasis | 2018 |
| 261 | GEMZ | Genetic Epilepsy Models in Zebrafish | 2019 |
| 262 | KILNEV | Killing Senescent Cells as a Novel Method to Eliminate Nevi | 2018 |
| 263 | HiMIN | Histone H3.3 oncogenic mutations: a role in genome instability through altered DNA repair and replication fork stability? | 2018 |
| 264 | NINTCORDEV | NIPBL and Integrator function and dysfunction in human cortical development | 2018 |
| 265 | NeuroRBP | Studying RNA-binding proteins involved in neural differentiation and degeneration | 2019 |
| 266 | MiniBRAIN | Investigating the pathogenic mechanisms underlying TUBB2B-related brain malformations using induced pluripotent stem cells and cerebral organoids. | 2019 |
| 267 | PCDfert | Identification of novel genes and mechanisms for PCD and male infertility | 2018 |
| 268 | PhaseControl | How cellular suicide programmes control phase transitions in fatty liver disease and liver cancer | 2018 |
| 269 | CharFL | Characterizing the fitness landscape on population and global scales | 2019 |
| 270 | GENOMIA | Genomic Modifiers of Inherited Aortapathy | 2019 |
| 271 | GrowCELL | The smallest of the small: determining size through cell number | 2018 |
| 272 | SENSATIONAL TETHERS | Tethers for sensory mechanotransduction: from molecules to perception | 2018 |
| 273 | cGEM | the Center for Genomics, Evolution and Medicine | 2018 |
| 274 | CTCFStableGenome | CTCF control of genome stability in ageing | 2019 |
| 275 | SUMMIT | Stepping Up mRNA Mutanome Immunotherapy | 2018 |
| 276 | PITBUL | Point-of-Care implementation of TB testing with ultra-fast Local Heating PCR | 2017 |
| 277 | PLEVOCON | Pleiotropy and Evolutionary Constraint | 2018 |
| 278 | RNAct | Enabling proteins with RNA recognition motifs for synthetic biology and bio-analytics. | 2019 |
| 279 | HISTOID | A Human iPS Cell-Derived Artificial Skeletal Muscle for Regenerative Medicine, Disease Modelling and Drug Screening | 2018 |
| 280 | BloodVariome | Genetic variation exposes regulators of blood cell formation in vivo in humans | 2018 |
| 281 | Mito-recombine | Homologous recombination and its application in manipulating animal mitochondrial DNA | 2019 |
| 282 | CytoPro | A breakthrough cancer diagnostic instrument to save 3000 years of human lives annually and up | 2018 |
| 283 | UNIFLUVAC | A novel universal influenza vaccine targeting epitopes of limited variability | 2018 |
| 284 | pHioniC | pH and Ion Transport in Pancreatic Cancer | 2018 |
| 285 | StarT | European Training Network to Diagnose, Understand and Treat Stargardt Disease, a Frequent Inherited Blinding Disorder | 2018 |
| 286 | iProg | Tailored cell-based therapies for frontotemporal dementia and related genetically defined CNS orphan indications | 2018 |
| 287 | CONQR | Translation and Commercialization of a QSOX1-inhibitory Antibody Targeting the Tumor Microenvironment in Breast Cancer | 2018 |
| 288 | DecodeDiabetes | Expanding the genetic etiological and diagnostic spectrum of monogenic diabetes mellitus | 2018 |
| 289 | FIT2GO | A toolbox for fitness landscapes in evolution | 2019 |
| 290 | AutoCAb | Automated computational design of site-targeted repertoires of camelid antibodies | 2019 |
| 291 | TE_INVASION | The evolutionary genetics of transposable element invasions | 2019 |
| 292 | SOLID | Suppression of Organelle Defects in Human Disease | 2019 |
| 293 | Neurovulnerability | Molecular mechanisms underlying selective neuronal death in motor neuron diseases | 2019 |
| 294 | evolSingleCellGRN | Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks | 2019 |
| 295 | SafeFate | Safeguarding Cell Fate by Terminal Repression during Development and Disease | 2019 |
| 296 | ProteoNE_dynamics | Surveillance mechanisms regulating nuclear envelope architecture and homeostasis | 2019 |
| 297 | CANCER SCAN | A Body Scan for Cancer Detection using Quantum Technology | 2019 |
| 298 | One4Two | All-in-one genetic test for fast and accurate diagnosis of the causes of infertility | 2019 |
| 299 | Agglomerates | Infinite Protein Self-Assembly in Health and Disease | 2019 |
| 300 | iHEAR | Gene therapy of inherited and acquired hearing loss | 2019 |
| 301 | ONCOFUM | Integrating the tissue-specificity and chronology of hereditary renal cancer predisposition | 2019 |
| 302 | PATRES-MDS | Pathogenesis and treatment of splicing factor mutant myelodysplastic syndromes | 2019 |
| 303 | IMaP | Imaging tumor vessels as a marker for p53 mutation status in cancer | 2020 |
| 304 | Oncogenic PI3-kinase | New biology of oncogenic PI 3-kinase | 2019 |
| 305 | EV-2C | Structural and functional studies of enterovirus 2C proteins: promising targets for antiviral therapy. | 2019 |
| 306 | CApaCITy | CAncer Stem Cell Imunoreceptors as potential Targets for skin Squamous cell carcinoma | 2019 |
| 307 | GuideArtifEvol | Tracking and guiding artificial enzyme evolution via landscape inference | 2019 |
| 308 | Degradation_ID | The role of protein degradation in FBXO11-related intellectual disability | 2019 |
| 309 | OSTers | Role of OligoSaccharyl Transferase enzymes in developmental signaling and congenital disorders of glycosylation | 2019 |
| 310 | SOS-CROPS | Solving the tangled ontogenesis of the stem for sustainable crops | 2019 |
| 311 | PanILC | Deciphering type 2 innate lymphoid cell/epithelial progenitor cell crosstalk in pancreas regeneration and neoplasia | 2019 |
| 312 | MechTransition | Regulatory mechanisms controlling a new mechanical Epithelial to Mesenchymal Transition in zebrafish | 2020 |
| 313 | FUSEDESIGN | Model-guided design of a stabilized pre-fusion class III viral fusogen, rabies virus glycoprotein | 2019 |
| 314 | 2D-MES | Two Dimensional Molecular Electronics Spectroscopy for DNA/RNA Mutation Recognition | 2020 |
| 315 | DADA2GT | Development of gene therapy and genome editing strategies to treat adenosine deaminase 2 deficiency | 2019 |
| 316 | ATTO-CONTROL | Attosecond X-ray Molecular Dynamics and Strong-Field Control | 2019 |
| 317 | SocBehGenoPheno | Genetic basis of emergent social behaviour from genotype-phenotype mapping | 2019 |
| 318 | GT-GM1 | Ex vivo gene therapy for GM1-gangliosidosis | 2020 |
| 319 | GUTPOLAR | Membrane trafficking as a link between cell polarity and intestinal absorptive function: from C. elegans to mammalian miniguts | 2019 |
| 320 | MalusEdit | Malus genome editing via CRISPR/Cas9 to develop sustainable pest free apples | 2019 |
| 321 | Prion Respiration | The Role of Complex I Assembly Factors during Prion Diseases: Insights into Mitochondrial Neurobiology | 2019 |
| 322 | STOPFOP | Saracatinib Trial tO Prevent FOP | 2019 |
| 323 | BREEDIT | A NOVEL BREEDING STRATEGY USING MULTIPLEX GENOME EDITING IN MAIZE | 2019 |
| 324 | MultiPan | A Multi-omics Approach To Decode Epigenetic Lesions In Pancreatic Cancer Development | 2019 |
| 325 | signalling dynamics | Bridging biophysics and cell biology: The role of G protein-coupled receptor conformations in signalling | 2020 |
| 326 | Recruit | Origin and Function of Tumor-Associated Macrophages and Mesenchymal Stromal Cells in GBM Subtypes | 2019 |
| 327 | LEPVORS | Identification and characterization of new drug resistance and host adaptation mechanisms in Mycobacterium leprae | 2019 |
| 328 | RTTOPHAGY | """Investigating autophagy enhancement as a therapeutic approach for the treatment of Rett syndrome.""" | 2019 |
| 329 | HARNESS | Harnessing experimental evolution of rhizobia for an integrative view of endosymbiosis | 2019 |
| 330 | GHSO | Generation of human steroid-producing organoids: a new approach to treat adrenal insufficiency | 2019 |
| 331 | EPICAN | Inhibiting tumor cell plasticity by targeting the epigenome in breast cancer | 2020 |
| 332 | JS_SCZ | Investigating impact of schizophrenia-associated non-coding variants on enhancer activity using brain organoids | 2020 |
| 333 | CANSAS | Clustering functional connectivity alterations in Autism Spectrum Disorders | 2020 |
| 334 | SUMO-PCDH10 | Physiological consequences of Protocadherin-10 sumoylation on neuronal function. | 2019 |
| 335 | ONCOTECT | Early detection of tumor DNA in liquid biopsies as a biomarker of cancer recurrence | 2019 |
| 336 | inSight | Moving a novel gene therapy paradigm to treat blindness to the market | 2019 |
| 337 | SPLITVAC | Harnessing the innate and adaptive immune system with targeted neoantigen based cancer vaccines | 2019 |
| 338 | Genetic Vaccine | Study the therapeutic and preventive potential of targeting oncogenic mutations with CRISPR-Cas9 technology | 2019 |
| 339 | PI3K-in-tolerance | PI3K delta role in dendritic cell antigen processing and presentation to control gut tolerance | 2019 |
| 340 | MetEpiC | P53-dependent Metabolic and Epigenetic Reprogramming in Carcinogenesis | 2020 |
| 341 | T-NHL SUPRESSORS | Tumor suppressor pathways counteracting oncogenic immune receptor signaling in T-Cell Lymphoma | 2019 |
| 342 | VACCIBIOME | Cancer Vaccines and Gut Microbiome: a rational approach to optimize cancer immunotherapy | 2019 |
| 343 | RASImmune | Targeting RAS driven tumour immune evasion | 2019 |
| 344 | MitoCRISTAE | Mitochondrial Cristae Biogenesis | 2019 |
| 345 | INSPIRATION | Investigation of the SNP-induced RNA structure variations between subgenomes in polyploid wheat | 2019 |
| 346 | FRAME | FRAME - tumor genome-based personalized anti-cancer vaccines off-the-shelf | 2019 |
| 347 | StreptoMANIAC | Cost and benefit of beta-lactam resistance in Streptococcus pneumoniae: interplay between the resistance determinants and the cell elongation/division components | 2019 |
| 348 | EvolSpliceKinetics | From co-transcriptional splicing kinetics to the evolutionary impact of exon and intron definition | 2020 |
| 349 | RASMAC | Regulatory Approved Software for Mutation Analysis in Cancer | 2019 |
| 350 | IMMUNOTRAP | Diagnosis test for immuno-oncology therapies. | 2019 |
| 351 | ENHPATHY | Molecular basis of human enhanceropathies | 2020 |
| 352 | I-GENE | In-vivo Gene Editing by NanotransducErs | 2019 |
| 353 | NEUcrest | Training European Experts in Multiscale Studies of Neural Crest Development and Disorders: from Patient to Model Systems and Back again. | 2019 |
| 354 | POWER-PATCH | Self-Powered Skin Patch for Cystic Fibrosis Diagnosis | 2020 |
| 355 | Aware | Aiding Antibiotic Development with Deep Analysis of Resistance Evolution | 2019 |
| 356 | MOLEC ANTI-ARRHYT | Resilience and Trigger Factors in Cardiac Arrhythmia: Risk Stratification and Drug Design | 2020 |
| 357 | TroyCAN | Redefining the esophageal stem cell niche – towards targeting of squamous cell carcinoma | 2020 |
| 358 | VIVA | Vaccine development against variable pathogens | 2020 |
| 359 | MitoRepairosome | Dissecting the mechanism of DNA repair in human mitochondria | 2020 |
| 360 | CHROMREP | Dissecting the chromatin response to DNA damage in silenced heterochromatin regions | 2019 |
| 361 | RNPdynamics | Multivalent interactions driving RNP dynamics in development and disease | 2020 |
| 362 | RhabdoEvo | Deciphering the cellular origin and evolution of malignant rhabdoid tumors | 2019 |
| 363 | RARITY | RAtional design of canceR ImmunoTherapY: one size does not fit all | 2019 |
| 364 | SIROCO | Sparing gene therapy for Inherited ROd COne dystrophies | 2019 |
| 365 | ROG | Real Organ Generation | 2019 |
| 366 | PARPinhibit | A systems biology approach to tackle PARP-inhibitors resistance and identify novel therapeutic targets to overcome it | 2020 |
| 367 | BIND | Brain Involvement iN Dystrophinopathies | 2020 |
| 368 | Trep-AB | Repurposing clinically approved antibacterial drugs for treponematoses therapy | 2020 |
| 369 | SILENT | Silent mutations in cancer | 2020 |
| 370 | TrojanDC | Harnessing dendritic cell reprogramming for cancer immunotherapy | 2020 |
| 371 | NATURE-ETN | Nucleic Acids for Future Gene Editing, Immunotherapy and Epigenetic Sequence Modification | 2020 |
| 372 | RNAVirFitness | The dark side of evolution: the deleterious mutational landscape of RNA viruses | 2020 |
| 373 | KineTic | New Reagents for Quantifying the Routing and Kinetics of T-cell Activation | 2020 |
| 374 | CTS-TEs-ADprogress | Cell type-specific molecular analysis of epigenetic changes and transposable element derepression in Alzheimer's disease progression | 2020 |
| 375 | ASTRA | ASsembly and phase Transitions of Ribonucleoprotein Aggregates in neurons: from physiology to pathology. | 2020 |
| 376 | Hemstem | Targeting leukaemia by modulating hematopoietic stem cell competitiveness | 2020 |
| 377 | BRCAstem | Monitoring cancer stem cell dynamics and therapeutic response in BRCA2-deficient breast tumour cells | 2020 |
| 378 | RE-GENESis | GENome Editing and delivery Strategies for REcoding the mammalian genome | 2020 |
| 379 | DiStRes | Disentangling the stringent response to engineer novel anti-persister drugs | 2020 |
| 380 | dcPolyWheat | Dominant cis-regulatory variation to improve quantitative traits in polyploid wheat | 2020 |
| 381 | DEAllAct | Dissecting and Engineering Allosteric Activation in a Biosynthetic Enzyme | 2020 |
| 382 | Pituitary enhancers | Identification and functional validation of novel enhancer sequences involved in pituitary gland development and pathology | 2020 |
| 383 | RENOPROTECT | Targeting tubular reabsorption for kidney protection | 2020 |
| 384 | GLoopID | Mechanisms underlying regulation and removal of G-quadruplex/R-loop transcription-replication conflicts | 2021 |
| 385 | POL2-TERM | Structural basis of co-transcriptional pre-mRNA 3’-end processing | 2020 |
| 386 | RegARcis | Role of the SWI/SNF complex in the Androgen Receptor cistrome regulation | 2020 |
| 387 | ADGENTHE-CDA | Advances in the Diagnosis and Gene Therapy of Congenital dyserythropoietic Anemia | 2020 |
| 388 | NOSCAR | decipheriNg Oncogenic SIgnalling patterns to break CAncer drug Resistance | 2020 |
| 389 | HiPhy | High Phytosterol variants towards improved feedstocks and biofortification of crops | 2020 |
| 390 | SecondCANCERinKIDS | What causes therapy-related malignancies in childhood cancer survivors? Dissecting the etiology of second cancers | 2020 |
| 391 | RASATaC | Regulating RAS Activity to Target RAS-Driven Cancers | 2020 |