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DRIVE SIGNED

Diabetes Reversing Implants with enhanced Viability and long-term Efficacy

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

DRIVE project word cloud

Explore the words cloud of the DRIVE project. It provides you a very rough idea of what is the project "DRIVE" about.

fold immunoprotection sufferers clinical stem insulin vitro limit chronic procedure vascularisation drug models pluripotent systemic safe mellitus cell survival efficacy disease immunosuppressive microparticles transport resistance blood drive islet vein injection interactive polymeric protective demand 382 degradation porous retrievable housed technologies people treatment worldwide diabetes harvesting added t2 macrocapsule microencapsulated storage portal engraftment shell compatibility hydrogels preservation poor time beta agents vivo profiles donor diabetics residence suite isdm glucose tuneable pancreatic sensitive cues t1d risk peritoneum containing therapy sources yield supply lifelong islets bio glycemic human injectable extremely deposition gel cath oxygenation create inadequate handling release biofunctionalised experts retention dimensional localised gels specialised cure catheter characterised brittle extended cells transplantation invasive laparoscopic million minimally omental ease t1

Project "DRIVE" data sheet

The following table provides information about the project.

Coordinator	NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Project website	http://www.drive-project.eu
Total cost	8˙832˙062 €
EC max contribution	8˙832˙061 € (100%)
Programme	1. H2020-EU.2.1.3.1. (Cross-cutting and enabling materials technologies)
Code Call	H2020-NMP-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2019-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	NATIONAL UNIVERSITY OF IRELAND GALWAY NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Galway)	coordinator	435˙576.00
2	ABIEL SOCIETA A RESPONSABILITA LIMITATA ABIEL SOCIETA A RESPONSABILITA LIMITATA Organization address address: VIALE DELLE SCIENZE SN city: PALERMO postcode: 90128 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PALERMO)	participant	887˙366.00
3	EXPLORA SRL EXPLORA SRL Organization address address: Via Giacomo Peroni 386 city: ROMA postcode: 131 website: www.explora-biotech.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	820˙000.00
4	ROYAL COLLEGE OF SURGEONS IN IRELAND ROYAL COLLEGE OF SURGEONS IN IRELAND Organization address address: Saint Stephen's Green 123 city: DUBLIN postcode: 2 website: www.rcsi.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	812˙141.00
5	BOSTON SCIENTIFIC LIMITED BOSTON SCIENTIFIC LIMITED Organization address address: BALLYBRIT BUSINESS PARK city: GALWAY postcode: H91 website: www.bostonscientific.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (GALWAY)	participant	715˙020.00
6	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Organization address address: BELFIELD city: DUBLIN postcode: 4 website: www.ucd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	700˙496.00
7	EBERHARD KARLS UNIVERSITAET TUEBINGEN EBERHARD KARLS UNIVERSITAET TUEBINGEN Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 website: www.uni-tuebingen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (TUEBINGEN)	participant	679˙153.00
8	INNOCORE TECHNOLOGIES BV INNOCORE TECHNOLOGIES BV Organization address address: L.J. ZIELSTRAWEG 1 city: Groningen postcode: 9713 GX website: www.innocore.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Groningen)	participant	600˙812.00
9	CONTIPRO AS CONTIPRO AS Organization address address: DOLNI DOBROUC 401 city: DOLNI DOBROUC postcode: 561 02 website: www.contipro.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (DOLNI DOBROUC)	participant	600˙625.00
10	DUBLIN CITY UNIVERSITY DUBLIN CITY UNIVERSITY Organization address address: Glasnevin city: DUBLIN postcode: 9 website: www.dcu.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	600˙000.00
11	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	579˙113.00
12	CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P. CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P. Organization address address: CALLE MONFORTE DE LEMOS 5 city: MADRID postcode: 28029 website: www.ciberisciii.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	550˙452.00
13	UNIVERSITEIT UTRECHT UNIVERSITEIT UTRECHT Organization address address: HEIDELBERGLAAN 8 city: UTRECHT postcode: 3584 CS website: www.uu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	498˙555.00
14	INNOVA SRL INNOVA SRL Organization address address: VIA CICERONE, 66 city: ROMA postcode: 193 website: www.innova-eu.net contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	273˙000.00
15	L'AZIENDA SOCIO SANITARIA TERRITORIALE (ASST) GRANDE OSPEDALE METROPOLITANO NIGUARDA L'AZIENDA SOCIO SANITARIA TERRITORIALE (ASST) GRANDE OSPEDALE METROPOLITANO NIGUARDA Organization address address: PIAZZA OSPEDALE MAGGIORE 3 city: MILANO postcode: 20162 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	79˙750.00
16	AZIENDA OSPEDALIERA OSPEDALE NIGUARDA CA' GRANDA AZIENDA OSPEDALIERA OSPEDALE NIGUARDA CA' GRANDA Organization address address: PIAZZA OSPEDALE MAGGIORE 3 city: MILANO postcode: 20162 website: www.ospedaleniguarda.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	0.00

Map

Project objective

Diabetes mellitus is a chronic disease characterised by high blood glucose due to inadequate insulin production and/or insulin resistance which affects 382 million people worldwide. Pancreatic islet transplantation is an extremely promising cure for insulin-sensitive diabetes mellitus (ISDM), but side effects of lifelong systemic immunosuppressive therapy, short supply of donor islets and their poor survival and efficacy in the portal vein limit the application of the current clinical procedure to the most at-risk brittle Type I diabetes (T1D) sufferers. The DRIVE consortium will develop a novel suite of bio-interactive hydrogels (β-Gel) and on-demand drug release systems to deliver islets in a protective macrocapsule (β-Shell) to the peritoneum with targeted deposition using a specialised injection catheter (β-Cath). Pancreatic islets will be microencapsulated in β-Gels; biofunctionalised injectable hydrogels containing immunosuppressive agents and polymeric microparticles with tuneable degradation profiles for localised delivery of efficacy cues. These β-Gels will be housed in a porous retrievable macrocapsule, β-Shell, for added retention, engraftment, oxygenation, vascularisation and immunoprotection of the islets. A minimally invasive laparoscopic procedure (O-Fold) will be used to create an omental fold and at the same time deliver β-Shell. An extended residence time in β-Gel will enhance long-term clinical efficacy of the islets and result in improved glycemic control. The novel β-Gels will also be developed as human three-dimensional in-vitro models of in-vivo behaviour. Islet harvesting and preservation technologies will be developed to facilitate their optimised yield, safe handling and transport, and ease of storage. DRIVE will also enable the future treatment of a broader range of T1 and insulin-sensitive T2 diabetics by working with induced pluripotent stem cell experts to ensure the compatibility of our system with future stem cell sources of β-cells.

Deliverables

List of deliverables.
Dissemination and Data Management Plan (DMP) and introductory project dissemination material	Documents, reports	2019-10-08 17:13:00
Outcomes of patients and citizens panelâ€™s report	Documents, reports	2019-10-08 17:12:44
Project website	Websites, patent fillings, videos etc.	2019-10-08 17:12:40
Report on patient advocacy activities	Documents, reports	2019-10-08 17:13:00

Take a look to the deliverables list in detail: detailed list of DRIVE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Aline Zbinden, Julia Marzi, Katharina SchlÃ¼nder, Christopher Probst, Max Urbanczyk, Scott Black, Eva M. Brauchle, Shannon L. Layland, Udo Kraushaar, Garry Duffy, Katja Schenke-Layland, Peter Loskill Non-invasive marker-independent high content analysis of a microphysiological human pancreas-on-a-chip model published pages: , ISSN: 0945-053X, DOI: 10.1016/j.matbio.2019.06.008	Matrix Biology	2019-08-30
2018	Federico Bertuzzi, Luciano De Carlis, Mario Marazzi, Antonio Gaetano Rampoldi, Matteo Bonomo, Barbara Antonioli, Marta Cecilia Tosca, Marta Galuzzi, Andrea Lauterio, Danila Fava, Patrizia Dorighet, Andrea De Gasperi, Giacomo Colussi Long-term Effect of Islet Transplantation on Glycemic Variability published pages: 840-846, ISSN: 0963-6897, DOI: 10.1177/0963689718763751	Cell Transplantation 27/5	2019-08-30
2017	Alan J .Ryan, Hugh S Oâ€™Neill, Garry P Duffy, Fergal J Oâ€™Brien Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation published pages: 66-71, ISSN: 1471-4892, DOI: 10.1016/j.coph.2017.07.013	Current Opinion in Pharmacology 36	2019-08-30
2018	Albert Espona-Noguera, JesÃºs Ciriza, Alberto CaÃ±ibano-HernÃ¡ndez, Luis Fernandez, Ignacio Ochoa, Laura Saenz del Burgo, Jose Luis Pedraz Tunable injectable alginate-based hydrogel for cell therapy in Type 1 Diabetes Mellitus published pages: 1261-1269, ISSN: 0141-8130, DOI: 10.1016/j.ijbiomac.2017.09.103	International Journal of Biological Macromolecules 107	2019-08-30
2017	S. Acreman, H. Brandhorst, A. Abraham, P.R.V. Johnson, D. Brandhorst Effect of Etanercept Concentration on Human Islet Integrity published pages: 2327-2329, ISSN: 0041-1345, DOI: 10.1016/j.transproceed.2017.11.002	Transplantation Proceedings 49/10	2019-08-30
2018	Bertuzzi F, Colussi G, Lauterio A, De Carlis L. Intramuscular islet allotransplantation in type 1 diabetes mellitus. published pages: , ISSN: 1128-3602, DOI: 10.26355/eurrev_201803_14588	Eur Rev Med Pharmacol Sci	2019-08-30
2019	Karina C. Scheiner, Roel F. Maas-Bakker, Thanh T. Nguyen, Ana M. Duarte, Gert Hendriks, LÃdia Sequeira, Garry P. Duffy, Rob Steendam, Wim E. Hennink, Robbert J. Kok Sustained Release of Vascular Endothelial Growth Factor from Poly(Îµ-caprolactone-PEG-Îµ-caprolactone)- b -Poly( l -lactide) Multiblock Copolymer Microspheres published pages: 11481-11492, ISSN: 2470-1343, DOI: 10.1021/acsomega.9b01272	ACS Omega 4/7	2019-08-30

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