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ADVANTAGE SIGNED

ADvanced Validation of A Novel TB Active disease diagnostic to address Global unmet needs: a European consortium approach

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ADVANTAGE project word cloud

Explore the words cloud of the ADVANTAGE project. It provides you a very rough idea of what is the project "ADVANTAGE" about.

stimulate efforts companies biomarkers validated global commercialisation cell security care deaths proteinlogic instrument healthcare proof disruptive demonstrated diagnostic confirm globally microfluidic assay plus reagents time validation practises improvements despite transitioning ground cartridge performance human supply successfully proven eight diagnostics commercial hold biosensia poorly costly uk point structured unmet reader meet protein clinical slow active company tb clear variety investment reduce burden summary regulatory samples eradicate accounting analytes advantage platform successful ing serum rapid massive standards breaking private mediated analytical bn million jobs panel elusive laboratory 1 biomarker poc selective patient profile 400 tuberculosis risks creation packages yield

Project "ADVANTAGE" data sheet

The following table provides information about the project.

Coordinator	PROTEINLOGIC LIMITED Organization address address: SHAKESPEARE HOUSE 42 NEWMARKET ROAD city: CAMBRIDGE CAMBRIDGESHIRE postcode: CB5 8EP website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.proteinlogic.com
Total cost	3˙893˙307 €
EC max contribution	3˙583˙396 € (92%)
Programme	1. H2020-EU.3.1. (SOCIETAL CHALLENGES - Health, demographic change and well-being) 2. H2020-EU.2.3.1. (Mainstreaming SME support, especially through a dedicated instrument)
Code Call	H2020-SMEINST-2-2014
Funding Scheme	SME-2
Starting year	2015
Duration (year-month-day)	from 2015-07-01 to 2018-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	PROTEINLOGIC LIMITED PROTEINLOGIC LIMITED Organization address address: SHAKESPEARE HOUSE 42 NEWMARKET ROAD city: CAMBRIDGE CAMBRIDGESHIRE postcode: CB5 8EP website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE CAMBRIDGESHIRE)	coordinator	2˙921˙750.00
2	BIOSENSIA LIMITED BIOSENSIA LIMITED Organization address address: UNIT 1 16 NOVA UCD UNIVERSITY COLLEGE DUBLIN BELFIELD city: DUBLIN postcode: 4 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	661˙646.00

Map

Project objective

Tuberculosis (TB) remains an EU and global healthcare priority resulting in over 1.4 million deaths each year. Despite this and efforts to reduce TB by the EU commission, the WHO and others, a simple, rapid, diagnostic test for active tuberculosis (TB) remains elusive. Current diagnostic procedures, while accounting for over $1 bn globally, are poorly selective for active TB, hold risks for healthcare personnel, are slow to yield results and costly.

The large potential and high unmet need provide a clear target for commercialisation of a point-of-care (POC) test. Using over 400 clinical samples, ProteinLogic (a UK based diagnostics company) have demonstrated proof of concept for a ground-breaking approach using a panel of protein biomarkers on human serum samples that profile the cell mediated patient response to TB.

The objectives of the eight structured work packages within this three year project are to build on the validation of the biomarker TB panel transitioning from a laboratory assay to Biosensia’s novel microfluidic POC platform that has already been successfully proven with a variety of human analytes. Reagents will be developed as part of this project to ensure reduced costs and security of commercial supply. A unique instrument reader plus TB cartridge-based product will be developed to meet EU regulatory standards. The products will be validated in order to confirm analytical and clinical performance, and to provide evidence of major time, cost & performance improvements compared to current TB testing practises. Successful commercialisation will lead to the creation of over 30 new jobs and will stimulate further private investment in each of the companies.

In summary, ADVANTAGE has the potential to deliver a disruptive POC TB diagnostic test that can help eradicate the massive TB burden not only in EU but also globally.

Deliverables

List of deliverables.
Clone scale	Websites, patent fillings, videos etc.	2019-05-30 13:18:55

Take a look to the deliverables list in detail: detailed list of ADVANTAGE deliverables.

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The information about "ADVANTAGE" are provided by the European Opendata Portal: CORDIS opendata.

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