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SATBIOFUN SIGNED

Genome editing for spatiotemporal analysis of centriolar SATellite BIOgenesis and FUNction in cellular stress responses

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SATBIOFUN project word cloud

Explore the words cloud of the SATBIOFUN project. It provides you a very rough idea of what is the project "SATBIOFUN" about.

manipulation    data    satellites    centre    receives    outgoing    central    independent    dissect    genome    ciliopathies    courses    overarching    resolution    biotech    base    little    normal    teaching    industry    edge    qualifications    trafficking    electron    automated    molecular    cellular    coupling    content    external    shows    training    organizing    super    cells    encoding    professional    composition    etiology    underpinning    antenna    biogenesis    encompasses    structure    dense    acquire    cell    morphometric    techniques    dna    computational    perform    microscopy    lie    career    quantitative    cytoplasmic    stimuli    disease    systematically    secondment    scientific    centrosome    stress    transfer    imaging    genes    centriolar    demonstrating    fellow    serves    alongside    function    microtubule    thereby    trained    cilium    complementary    establishing    first    time    termed    cutting    return    regulation    maturity    whilst    primary    group    granules    mechanisms    proteins    skills    satellite    mutations    editing    follow    assembly    protein    delineate    position   

Project "SATBIOFUN" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://pelletierlab.org/suzanna-prosser_project-summary/
 Total cost 233˙555 €
 EC max contribution 233˙555 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2019-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 233˙555.00
2    Mount Sinai Hospital CA (TORONTO) partner 0.00

Map

 Project objective

The centrosome is the major microtubule-organizing centre of a cell. It also serves as the base for the primary cilium, an antenna-like structure that allows cells to respond to external stimuli. Around the centrosome lie a number of electron dense cytoplasmic granules, termed centriolar satellites. These are involved in protein trafficking and are crucial for normal centrosome and cilium assembly and function. However, little is known about satellite composition, biogenesis or regulation. Mutations in a number of genes encoding satellite proteins cause ciliopathies, demonstrating their importance in the etiology of disease. Emerging data also shows that satellites contribute to the cellular stress response. The central scientific goal of this proposal is to systematically dissect, for the first time, the molecular mechanisms underpinning centriolar satellite biogenesis and function. Coupling genome-editing and cutting-edge imaging techniques we will perform morphometric quantitative analysis of satellite proteins to delineate their specific role in the cellular response to stress. This project encompasses an Outgoing Phase during which the Fellow will be trained in advanced, high-content, automated, and super-resolution microscopy, and computational analysis to study satellite biogenesis and function. Within this phase a secondment to the biotech sector will occur during which the Fellow will learn cutting-edge DNA manipulation methods. The Return Phase allows the transfer of this knowledge to Europe whilst the Fellow receives training in the analysis of stress responses. Alongside this the Fellow will follow a program of courses to acquire a range of complementary skills, including industry-related skills and teaching qualifications. Together, this will accomplish the overarching objective of developing the Fellow’s career to a position of professional maturity, thereby facilitating her long-term goal of establishing her own independent research group in Europe.

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The information about "SATBIOFUN" are provided by the European Opendata Portal: CORDIS opendata.

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