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SATBIOFUN SIGNED

Genome editing for spatiotemporal analysis of centriolar SATellite BIOgenesis and FUNction in cellular stress responses

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SATBIOFUN project word cloud

Explore the words cloud of the SATBIOFUN project. It provides you a very rough idea of what is the project "SATBIOFUN" about.

organizing    proteins    scientific    regulation    satellites    protein    receives    techniques    mutations    transfer    satellite    skills    stimuli    thereby    fellow    acquire    assembly    biotech    time    overarching    base    cilium    qualifications    composition    training    microtubule    dna    data    computational    secondment    cellular    quantitative    resolution    systematically    serves    cytoplasmic    outgoing    underpinning    group    dense    delineate    trained    professional    manipulation    cutting    genes    normal    biogenesis    microscopy    content    trafficking    independent    central    dissect    super    granules    whilst    teaching    position    function    establishing    termed    shows    return    centre    disease    first    molecular    encoding    external    imaging    stress    follow    antenna    career    centrosome    mechanisms    structure    automated    lie    etiology    editing    edge    primary    alongside    ciliopathies    little    centriolar    courses    cell    complementary    maturity    electron    encompasses    industry    perform    genome    coupling    demonstrating    cells    morphometric   

Project "SATBIOFUN" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://pelletierlab.org/suzanna-prosser_project-summary/
 Total cost 233˙555 €
 EC max contribution 233˙555 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2019-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 233˙555.00
2    Mount Sinai Hospital CA (TORONTO) partner 0.00

Map

 Project objective

The centrosome is the major microtubule-organizing centre of a cell. It also serves as the base for the primary cilium, an antenna-like structure that allows cells to respond to external stimuli. Around the centrosome lie a number of electron dense cytoplasmic granules, termed centriolar satellites. These are involved in protein trafficking and are crucial for normal centrosome and cilium assembly and function. However, little is known about satellite composition, biogenesis or regulation. Mutations in a number of genes encoding satellite proteins cause ciliopathies, demonstrating their importance in the etiology of disease. Emerging data also shows that satellites contribute to the cellular stress response. The central scientific goal of this proposal is to systematically dissect, for the first time, the molecular mechanisms underpinning centriolar satellite biogenesis and function. Coupling genome-editing and cutting-edge imaging techniques we will perform morphometric quantitative analysis of satellite proteins to delineate their specific role in the cellular response to stress. This project encompasses an Outgoing Phase during which the Fellow will be trained in advanced, high-content, automated, and super-resolution microscopy, and computational analysis to study satellite biogenesis and function. Within this phase a secondment to the biotech sector will occur during which the Fellow will learn cutting-edge DNA manipulation methods. The Return Phase allows the transfer of this knowledge to Europe whilst the Fellow receives training in the analysis of stress responses. Alongside this the Fellow will follow a program of courses to acquire a range of complementary skills, including industry-related skills and teaching qualifications. Together, this will accomplish the overarching objective of developing the Fellow’s career to a position of professional maturity, thereby facilitating her long-term goal of establishing her own independent research group in Europe.

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The information about "SATBIOFUN" are provided by the European Opendata Portal: CORDIS opendata.

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