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SATBIOFUN SIGNED

Genome editing for spatiotemporal analysis of centriolar SATellite BIOgenesis and FUNction in cellular stress responses

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SATBIOFUN project word cloud

Explore the words cloud of the SATBIOFUN project. It provides you a very rough idea of what is the project "SATBIOFUN" about.

normal    techniques    trafficking    mutations    encoding    function    demonstrating    skills    automated    protein    genome    dna    acquire    industry    composition    quantitative    fellow    regulation    organizing    receives    microscopy    qualifications    imaging    base    centrosome    teaching    morphometric    scientific    centriolar    cellular    outgoing    career    content    follow    return    ciliopathies    primary    central    etiology    cilium    assembly    cutting    coupling    manipulation    perform    biotech    edge    position    establishing    systematically    overarching    dissect    microtubule    cells    thereby    courses    whilst    dense    proteins    electron    external    granules    mechanisms    stress    group    secondment    transfer    cell    delineate    complementary    time    trained    encompasses    stimuli    disease    training    super    structure    alongside    satellite    satellites    resolution    computational    genes    termed    cytoplasmic    shows    editing    molecular    serves    maturity    data    centre    antenna    professional    biogenesis    independent    first    little    underpinning    lie   

Project "SATBIOFUN" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://pelletierlab.org/suzanna-prosser_project-summary/
 Total cost 233˙555 €
 EC max contribution 233˙555 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2019-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 233˙555.00
2    Mount Sinai Hospital CA (TORONTO) partner 0.00

Map

 Project objective

The centrosome is the major microtubule-organizing centre of a cell. It also serves as the base for the primary cilium, an antenna-like structure that allows cells to respond to external stimuli. Around the centrosome lie a number of electron dense cytoplasmic granules, termed centriolar satellites. These are involved in protein trafficking and are crucial for normal centrosome and cilium assembly and function. However, little is known about satellite composition, biogenesis or regulation. Mutations in a number of genes encoding satellite proteins cause ciliopathies, demonstrating their importance in the etiology of disease. Emerging data also shows that satellites contribute to the cellular stress response. The central scientific goal of this proposal is to systematically dissect, for the first time, the molecular mechanisms underpinning centriolar satellite biogenesis and function. Coupling genome-editing and cutting-edge imaging techniques we will perform morphometric quantitative analysis of satellite proteins to delineate their specific role in the cellular response to stress. This project encompasses an Outgoing Phase during which the Fellow will be trained in advanced, high-content, automated, and super-resolution microscopy, and computational analysis to study satellite biogenesis and function. Within this phase a secondment to the biotech sector will occur during which the Fellow will learn cutting-edge DNA manipulation methods. The Return Phase allows the transfer of this knowledge to Europe whilst the Fellow receives training in the analysis of stress responses. Alongside this the Fellow will follow a program of courses to acquire a range of complementary skills, including industry-related skills and teaching qualifications. Together, this will accomplish the overarching objective of developing the Fellow’s career to a position of professional maturity, thereby facilitating her long-term goal of establishing her own independent research group in Europe.

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The information about "SATBIOFUN" are provided by the European Opendata Portal: CORDIS opendata.

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