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NVHSC SIGNED

Neurovascular interplay in the hematopoietic stem cell niches in homeostasis and myeloproliferative neoplasias

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NVHSC project word cloud

Explore the words cloud of the NVHSC project. It provides you a very rough idea of what is the project "NVHSC" about.

interaction research elusive msc nerves actively located arteriolar genetic closely neurons facs hematopoietic influence bm vasculature cell direct downstream therapies interact malignant combination besides leukemic vessels whereas imaging compartment mesenchymal progression sinusoidal steady maintenance mouse sympathetic proliferating arterioles homeostasis ec leukemia populations stem cells rna sequencing models niches resolution quiescence ng2nesbright marrow niche therapeutic mount form balance activation hsc bone vascular leprneslow blood quiescent perivascular

Project "NVHSC" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.haem.cam.ac.uk/staff/senior-staff/dr-simon-mendez-ferrer/
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-04-01 to 2018-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	183˙454.00

Map

Project objective

Research of the bone marrow (BM) hematopoietic stem cell (HSC) niche has long been the study of mesenchymal cell populations. Only recently, distinct vascular niches have been identified to balance HSC activation and quiescence. Whereas arterioles together with sympathetic nerves and NG2Nesbright cells form a niche for quiescent HSC, actively proliferating HSC are closely located to sinusoidal vessels and LepRNeslow cells. However, it is still elusive how different blood vessels interact with different niche cells in distinct vascular niches during BM homeostasis and leukemic progression. Therefore, the present proposal aims at studying the role of distinct vascular BM niches in controlling HSC maintenance and malignant progression by means of genetic mouse models, FACS analysis, high resolution whole mount BM imaging and RNA sequencing. Besides investigating the direct influence of EC on HSC in different vascular niches, the interaction of EC with perivascular MSC and particularly neurons will be compared between the sinusoidal and arteriolar niche under steady-state and malignant conditions. Changes of the vasculature and downstream effects on HSC and other niche cells will be analyzed during therapeutic targeting of leukemia and the vascular compartment will be evaluated as novel target for niche-targeting leukemia combination therapies.

Publications

List of publications.
year	authors and title	journal	last update
2017	Claudia Korn, SimÃ³n MÃ©ndez-Ferrer Myeloid malignancies and the microenvironment published pages: 811-822, ISSN: 0006-4971, DOI: 10.1182/blood-2016-09-670224	Blood 129/7	2019-06-13

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