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EvolAge

Experimental Evolution of Aging: the genetic link between lifespan, nutrient sensing and fat metabolism

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EvolAge project word cloud

Explore the words cloud of the EvolAge project. It provides you a very rough idea of what is the project "EvolAge" about.

candidate plan fat suggest contribution stones reveal alleles metabolism lived inbred unknown manipulations rnai effect animal resistance aging stepping sequenced recombinant species functional toward compare responsible subtle exact innovative nutrient society completely genetic underlie combination data transgenic population developmental correlation reproduction melanogaster extended datasets laboratory genomes undernutrition postponed populations genes experimentally improvement health phenotypes variation genome lines diet drosophila lifespan ee natural human mechanisms humans mutants synthetic whereas science sensing elucidated link powerful life

Project "EvolAge" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE DE LAUSANNE Organization address address: Quartier Unil-Centre Bâtiment Unicentre city: LAUSANNE postcode: 1015 website: www.unil.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Project website	http://www.unil.ch/dee/home/menuinst/people/post-docs--associates/dr-katja-hoedjes.html
Total cost	187˙419 €
EC max contribution	187˙419 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2019-06-02

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE DE LAUSANNE UNIVERSITE DE LAUSANNE Organization address address: Quartier Unil-Centre Bâtiment Unicentre city: LAUSANNE postcode: 1015 website: www.unil.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	coordinator	187˙419.00

Map

Project objective

Reproduction and diet are the two main factors that affect aging in a wide range of animal species, including humans. Recent studies suggest that the link between these factors and aging is controlled by genes related to fat metabolism and nutrient sensing, but the exact role of these genes in lifespan and late-life health remains to be elucidated. In addition, most of the known 'aging' genes were identified with laboratory-generated mutants or transgenic manipulations. The genetic mechanisms that control natural variation in lifespan, which may depend on subtle changes to known 'aging' genes or completely different genes, are still unknown, whereas these natural alleles are responsible for aging phenotypes observed in natural populations, including in humans.

In this project, I propose to study a unique set of experimentally evolved (EE) Drosophila melanogaster lines that have developed an extended lifespan in response to (1) selection on postponed reproduction and/or (2) resistance to developmental undernutrition. We have sequenced the genomes of these lines and identified natural alleles that may underlie variation in lifespan and now plan to (1) compare our genome data to datasets of other long-lived Drosophila lines to identify the most promising candidate genes/alleles for functional testing. (2) I will characterize fat metabolism in the EE lines to investigate the correlation between fat metabolism and aging. (3) I will use the powerful and innovative combination of transgenic RNAi and a 'synthetic recombinant inbred population' approach to test if and how my candidate genes/alleles have an effect on lifespan and fat metabolism.

I expect that my results, which may reveal natural alleles that affect aging and how metabolism is involved in this process, will provide a significant contribution to the field of aging research. This is relevant to both science and society, and may provide important stepping-stones toward the improvement of human health.

Publications

List of publications.
year	authors and title	journal	last update
2017	Katja M Hoedjes, Marisa A Rodrigues, Thomas Flatt Amino acid modulation of lifespan and reproduction in Drosophila published pages: 118-122, ISSN: 2214-5745, DOI: 10.1016/j.cois.2017.07.005	Current Opinion in Insect Science 23	2019-09-25

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EVOLAGE" project.

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Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

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The information about "EVOLAGE" are provided by the European Opendata Portal: CORDIS opendata.