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INSPIRED SIGNED

Targeting IRE1 in disease

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

INSPIRED project word cloud

Explore the words cloud of the INSPIRED project. It provides you a very rough idea of what is the project "INSPIRED" about.

classes modulators translational er ire1 technologies suppress signalling aberrant activated inspired skills commercial society determines misfolded considerably disorders unfolded drug network cell overarching career diseases sensor experts staff generate data transducer interfere preclinical signal protein accumulation interactions intersectoral endoplasmic disease environments advancing cancer accelerate interdisciplinary dynamic cancers health activation cells perspectives economic benefit drive innovation shared therapeutics culture occurs expertise forming participate proteins members neurodegenerative exposed reticulum stress fate upr termed productive

Project "INSPIRED" data sheet

The following table provides information about the project.

Coordinator	NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Project website	http://inspired-network.eu/
Total cost	886˙500 €
EC max contribution	832˙500 € (94%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2016
Funding Scheme	MSCA-RISE
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	NATIONAL UNIVERSITY OF IRELAND GALWAY NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Galway)	coordinator	364˙500.00
2	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	193˙500.00
3	ENIOS APPLICATIONS IDIOTIKI KEFALAIOUCHIKI ETAIREIA ENIOS APPLICATIONS IDIOTIKI KEFALAIOUCHIKI ETAIREIA Organization address address: AL. PANTOU 25 city: KALLITHEA postcode: 17671 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (KALLITHEA)	participant	162˙000.00
4	CELL STRESS DISCOVERIES LIMITED CELL STRESS DISCOVERIES LIMITED Organization address address: UNIT 204, NUIG BUSINESS INNOVATION CENTRE, NEWCASTLE ROAD city: GALWAY postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (GALWAY)	participant	90˙000.00
5	GOETEBORGS UNIVERSITET GOETEBORGS UNIVERSITET Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 website: www.gu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOETEBORG)	participant	13˙500.00
6	METASYSX GMBH METASYSX GMBH Organization address address: AM MÜHLENBERG 11 city: POTSDAM postcode: 14476 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (POTSDAM)	participant	9˙000.00
7	MANNKIND CORPORATION MANNKIND CORPORATION Organization address address: NORTH AVENUE PAINE 28903 city: VALENCIA postcode: 91355 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (VALENCIA)	partner	0.00
8	ORINOVE INC ORINOVE INC Organization address address: 3537 OLD CONEJO ROAD SUITE 104 city: NEWBURY PARK postcode: 91320 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NEWBURY PARK)	partner	0.00
9	UNIVERSIDAD DE CHILE UNIVERSIDAD DE CHILE Organization address address: Av. Libertador Bernardo O'Higgins 1058 city: SANTIAGO postcode: 10 website: www.uchile.cl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CL (SANTIAGO)	partner	0.00

Map

Project objective

The overarching objective of this Interfere to Suppress or Promote IRE1 (INSPIRED) RISE programme is to drive research and innovation in cell stress and drug development for cancer and neurodegenerative diseases by forming an interdisciplinary and intersectoral network of experts with strong, dynamic and productive interactions. The partners will work together, each bringing their unique expertise, to develop new classes of therapeutics for these common diseases. By fostering a shared culture of research, innovation and collaboration, the participants will accelerate advances in the field of cell stress responses. The staff members who participate in the programme will develop new skills, learn new technologies and be exposed to new environments which will considerably enhance their career opportunities. Advancing drug development in the stress response field has potential translational and commercial opportunities for the participants and will benefit European society as a whole from economic and health perspectives. IRE1 is a stress sensor and signal transducer, activated in response to the accumulation of misfolded proteins in the endoplasmic reticulum (ER). Its activation is part of a process termed the unfolded protein response (UPR) that determines the fate of cells in response to ER stress. The INSPIRED consortium will focus on understanding IRE1 signalling and its role in the stress response in order to target it in specific diseases such as cancers and neurodegenerative disorders where aberrant IRE1 signalling occurs. Research carried out by INSPIRED partners will develop new IRE1 modulators and generate preclinical data to support targeting IRE1 in cancers and neurodegenerative disease.

Deliverables

List of deliverables.
Consortium web site established	Websites, patent fillings, videos etc.	2019-08-30 13:19:40
Creation of Facebook & Twitter accounts	Websites, patent fillings, videos etc.	2019-08-30 13:19:40

Take a look to the deliverables list in detail: detailed list of INSPIRED deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Denisse Sepulveda, Diego Rojas-Rivera, Diego A. RodrÃguez, Jody Groenendyk, Andres KÃ¶hler, Cynthia Lebeaupin, Shinya Ito, Hery Urra, Amado Carreras-Sureda, Younis Hazari, Mireille Vasseur-Cognet, Maruf M.U. Ali, Eric Chevet, Gisela Campos, Patricio Godoy, Tomas Vaisar, BÃ©atrice Bailly-Maitre, Kazuhiro Nagata, Marek Michalak, Jimena Sierralta, Claudio Hetz Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1Î± published pages: 238-252.e7, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.12.028	Molecular Cell 69/2	2019-08-30
2018	StÃ©phanie Lhomond, Tony Avril, Nicolas Dejeans, Konstantinos Voutetakis, Dimitrios Doultsinos, Mari McMahon, RaphaÃ«l Pineau, Joanna Obacz, Olga Papadodima, Florence Jouan, Heloise Bourien, Marianthi Logotheti, GwÃ©naÃ«le JÃ©gou, NÃ©stor Pallaresâ€Lupon, Kathleen Schmit, Pierreâ€Jean Le Reste, Amandine Etcheverry, Jean Mosser, Kim Barroso, Elodie VaulÃ©on, Marion Maurel, Afshin Samali, John B Patterson, Olivier Pluquet, Claudio Hetz, VÃ©ronique Quillien, Aristotelis Chatziioannou, Eric Chevet Dual IRE1 RNase functions dictate glioblastoma development published pages: e7929, ISSN: 1757-4676, DOI: 10.15252/emmm.201707929	EMBO Molecular Medicine 10/3	2019-08-30
2017	Philippe PihÃ¡n, Amado Carreras-Sureda, Claudio Hetz BCL-2 family: integrating stress responses at the ER to control cell demise published pages: 1478-1487, ISSN: 1350-9047, DOI: 10.1038/cdd.2017.82	Cell Death and Differentiation 24/9	2019-08-30
2018	Hery Urra, Daniel R. Henriquez, JosÃ© CÃ¡novas, David Villarroel-Campos, Amado Carreras-Sureda, Eduardo Pulgar, Emiliano Molina, Younis M. Hazari, Celia M. Limia, SebastiÃ¡n Alvarez-Rojas, Ricardo Figueroa, Rene L. Vidal, Diego A. Rodriguez, Claudia A. Rivera, Felipe A. Court, AndrÃ©s Couve, Ling Qi, Eric Chevet, Ryoko Akai, Takao Iwawaki, Miguel L. Concha, Ãlvaro Glavic, Christian Gonzalez-Billault, Claudio Hetz IRE1Î± governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A published pages: 942-953, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0141-0	Nature Cell Biology 20/8	2019-08-30
2019	Aitor Almanza, Antonio Carlesso, Chetan Chintha, Stuart Creedican, Dimitrios Doultsinos, Brian Leuzzi, Andreia LuÃs, Nicole McCarthy, Luigi Montibeller, Sanket More, Alexandra Papaioannou, Franziska PÃ¼schel, Maria Livia Sassano, Josip Skoko, Patrizia Agostinis, Jackie de Belleroche, Leif A. Eriksson, Simone Fulda, Adrienne M. Gorman, Sandra Healy, Andrey Kozlov, Cristina MuÃ±oz-Pinedo, Markus Rehm, Eric Chevet, Afshin Samali Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications published pages: 241-278, ISSN: 1742-464X, DOI: 10.1111/febs.14608	The FEBS Journal 286/2	2019-08-30
2017	Gabriela Mercado, Claudio Hetz Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts published pages: 1544-1547, ISSN: 0006-8950, DOI: 10.1093/brain/awx107	Brain 140/6	2019-08-30
2018	Eoghan McGrath, Susan Logue, Katarzyna Mnich, Shane Deegan, Richard JÃ¤ger, Adrienne Gorman, Afshin Samali The Unfolded Protein Response in Breast Cancer published pages: 344, ISSN: 2072-6694, DOI: 10.3390/cancers10100344	Cancers 10/10	2019-08-30
2017	Danilo B. Medinas, Jose V. GonzÃ¡lez, Paulina Falcon, Claudio Hetz Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2017.00216	Frontiers in Molecular Neuroscience 10	2019-08-30
2017	Leslie Bargsted, Danilo B. Medinas, Francisca MartÃnez Traub, Pablo Rozas, Natalia MuÃ±oz, Melissa Nassif, Carolina Jerez, Alejandra Catenaccio, Felipe A. Court, Claudio Hetz, Soledad Matus Disulfide cross-linked multimers of TDP-43 and spinal motoneuronÂ loss in a TDP-43A315T ALS/FTD mouse model published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-14399-5	Scientific Reports 7/1	2019-08-30
2018	Claudio Hetz, Feroz R. Papa The Unfolded Protein Response and Cell Fate Control published pages: 169-181, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.06.017	Molecular Cell 69/2	2019-08-30
2017	Amado Carreras-Sureda, Philippe PihÃ¡n, Claudio Hetz The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics published pages: , ISSN: 2234-943X, DOI: 10.3389/fonc.2017.00055	Frontiers in Oncology 7	2019-08-30
2018	Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, RÃ³isÃn M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard JÃ¤ger, Adrienne M. Gorman, Afshin Samali Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05763-8	Nature Communications 9/1	2019-08-30
2017	Joanna Obacz, Tony Avril, Camila Rubio-PatiÃ±o, Jozef P. Bossowski, Aeid Igbaria, Jean-Ehrland Ricci, Eric Chevet Regulation of tumor-stroma interactions by the unfolded protein response published pages: , ISSN: 1742-464X, DOI: 10.1111/febs.14359	The FEBS Journal	2019-08-30

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