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T2DM and AD SIGNED

Study of the interaction between metabolic stress and a specific genetic background on the contribution of sporadic Alzheimer's Disease

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

T2DM and AD project word cloud

Explore the words cloud of the T2DM and AD project. It provides you a very rough idea of what is the project "T2DM and AD" about.

propensity weaknesses metabolic onset epigenetic suffice forms mice disease genome se ad linked association t2dm behavioral single brains alzheimer wild risk insufficiency thought cd2ap perception mind effect bearing diabetes perform interaction mechanisms disturbance familial instead once electrophysiological link gene consequence populations biochemical sorl1 genetically aging mellitus phenotypic environment nor polymorphisms deficient aged either appearance age different genetic load predisposing gwas circumstances neuronal environmental

Project "T2DM and AD" data sheet

The following table provides information about the project.

Coordinator	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://embomolmed.embopress.org/content/10/1/7.long
Total cost	170˙121 €
EC max contribution	170˙121 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-04-01 to 2019-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	170˙121.00

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Project objective

Different from the familial forms, late onset Alzheimer’s disease (LOAD) is not the consequence of a single cause: neither aging, nor genetic polymorphisms nor an environmental disturbance do, per se, suffice to produce this disease. It is currently thought that instead disease is the consequence of an interaction of all the above circumstances. With that perception in mind, I here propose to study i) the effect of type 2 diabetes mellitus (T2DM), a metabolic disturbance strongly associated with propensity to LOAD, on the appearance of AD-associated features (biochemical, electrophysiological and behavioral) ii) in the brains of aged mice iii) bearing a genetic insufficiency in either the gene SORL1 or in CD2AP, both of which have been linked to higher risk of late onset AD in recent familial genome wide association studies (GWAS). Once the phenotypic analysis is completed, I will perform genome wide epigenetic analysis of T2DM on specific neuronal populations of wild type and the genetically deficient mice. All in all, my studies should help to determine the mechanisms by which environment, age and disease-predisposing genetic weaknesses link together to produce this disease.

Publications

List of publications.
year	authors and title	journal	last update
2018	Francesc X Guix, Carlos G Dotti Could blocking the formation of amyloid channels rescue Alzheimer\'s phenotype? published pages: 7-9, ISSN: 1757-4676, DOI: 10.15252/emmm.201708491	EMBO Molecular Medicine 10/1	2019-05-14

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The information about "T2DM AND AD" are provided by the European Opendata Portal: CORDIS opendata.