OptoBETA SIGNED
Multicellular regulation of insulin secretion from pancreatic islets
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0OptoBETA project word cloud
Explore the words cloud of the OptoBETA project. It provides you a very rough idea of what is the project "OptoBETA" about.
Project "OptoBETA" data sheet
The following table provides information about the project.
| Coordinator |
THE UNIVERSITY OF BIRMINGHAM
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Project website | https://www.birmingham.ac.uk/staff/profiles/metabolism-systems/hodson-david.aspx |
| Total cost | 1˙681˙468 € |
| EC max contribution | 1˙681˙468 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-06-01 to 2022-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE UNIVERSITY OF BIRMINGHAM | UK (BIRMINGHAM) | coordinator | 1˙681˙468.00 |
Map
Project objective
Type 2 diabetes mellitus, one of the major healthcare challenges of our time, is characterized by failure of beta cells to functionally adapt to increased peripheral insulin resistance. The resulting chronic elevations in blood glucose concentration are associated with heart, kidney, liver, nerve and retinal disease, as well as cancer. Here, by combining novel optogenetic, photopharmacological and innovative imaging approaches, we aim to unravel the complexity underlying the multicellular regulation of insulin secretion from islets of Langerhans during health and disease. In particular, we will examine a role for privileged pacemakers/hubs in orchestrating population responses to stimuli, identify what makes these specialized cells unique at the RNA/protein level, and understand how they contribute to islet development and failure. Furthermore, we will address whether the intraislet regulation of insulin secretion operates in vivo to determine glucose homeostasis, focusing on the neural-endocrine interface. Lastly, the mechanisms underlying islet cross-talk will be investigated directly in situ within the pancreas of living mice, paying close attention to the roles of the vasculature and secreted factors. As such, these studies should unveil a new route for restoration of insulin secretion in man, as well as provide the foundation for the de novo construction of islets for transplantation.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Sophie R. Sayers, Rebecca L. Beavil, Nicholas H. F. Fine, Guo C. Huang, Pratik Choudhary, Kamila J. Pacholarz, Perdita E. Barran, Sam Butterworth, Charlotte E. Mills, J. Kennedy Cruickshank, Marta P. Silvestre, Sally D. Poppitt, Anne-Thea McGill, Gareth G. Lavery, David J. Hodson, Paul W. Caton Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes published pages: , ISSN: 0012-186X, DOI: 10.1007/s00125-019-05029-y |
Diabetologia | 2019-12-16 |
| 2019 |
Rebecca J. Thompson, Alice Fletcher, Katie Brookes, Hannah Nieto, Mohammed M. Alshahrani, Jonathan W. Mueller, Nicholas H.F. Fine, David J. Hodson, Kristien Boelaert, Martin L. Read, Vicki E. Smith, Christopher J. McCabe Dimerization of the Sodium/Iodide Symporter published pages: 1485-1498, ISSN: 1050-7256, DOI: 10.1089/thy.2019.0034 |
Thyroid 29/10 | 2019-12-16 |
| 2019 |
Daniela Nasteska, Katrina Viloria, Lewis Everett, David J. Hodson Informing β-cell regeneration strategies using studies of heterogeneity published pages: S49-S59, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2019.06.004 |
Molecular Metabolism 27 | 2019-12-16 |
| 2019 |
Siew H. Yip, Nicola Romanò, Papillon Gustafson, David J. Hodson, Eloise J. Williams, Ilona C. Kokay, Agnes O. Martin, Patrice Mollard, David R. Grattan, Stephen J. Bunn Elevated Prolactin during Pregnancy Drives a Phenotypic Switch in Mouse Hypothalamic Dopaminergic Neurons published pages: 1787-1799.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.01.067 |
Cell Reports 26/7 | 2019-12-16 |
| 2019 |
Michael W. O\'Reilly, Connar S.J. Westgate, Catherine Hornby, Hannah Botfield, Angela E. Taylor, Keira Markey, James L. Mitchell, William J. Scotton, Susan P. Mollan, Andreas Yiangou, Carl Jenkinson, Lorna C. Gilligan, Mark Sherlock, James Gibney, Jeremy W. Tomlinson, Gareth G. Lavery, David J. Hodson, Wiebke Arlt, Alexandra J. Sinclair A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.125348 |
JCI Insight | 2019-12-16 |
| 2017 |
Zenobia B. Mehta, Natalie R. Johnston, Marie-Sophie Nguyen-Tu, Johannes Broichhagen, Peter Schultz, Dean P. Larner, Isabelle Leclerc, Dirk Trauner, Guy A. Rutter, David J. Hodson Remote control of glucose homeostasis in vivo using photopharmacology published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-00397-0 |
Scientific Reports 7/1 | 2019-05-14 |
| 2017 |
Jaimini Cegla, Ben J Jones, James V Gardiner, David J Hodson, Thomas Marjot, Emma R McGlone, Tricia M Tan, Stephen R Bloom RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling published pages: 2680-2693, ISSN: 0013-7227, DOI: 10.1210/en.2016-1755 |
Endocrinology 158/8 | 2019-05-14 |
| 2017 |
Ryan K. Mitchell, Marie-Sophie Nguyen-Tu, Pauline Chabosseau, Rebecca M. Callingham, Timothy J. Pullen, Rebecca Cheung, Isabelle Leclerc, David J. Hodson, Guy A. Rutter The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca 2+ dynamics in adult mice published pages: 8892-8906, ISSN: 0021-9258, DOI: 10.1074/jbc.M117.784629 |
Journal of Biological Chemistry 292/21 | 2019-05-14 |
| 2018 |
Guadalupe Navarro, Camille Allard, Jamie J. Morford, Weiwei Xu, Suhuan Liu, Adrien J.R. Molinas, Sierra M. Butcher, Nicholas H.F. Fine, Manuel Blandino-Rosano, Venkata N. Sure, Sangho Yu, Rui Zhang, Heike Münzberg, David A. Jacobson, Prasad V. Katakam, David J. Hodson, Ernesto Bernal-Mizrachi, Andrea Zsombok, Franck Mauvais-Jarvis Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.98607 |
JCI Insight 3/12 | 2019-05-14 |
| 2017 |
Tom Podewin, Johannes Broichhagen, Christina Frost, Dieter Groneberg, Julia Ast, Helena Meyer-Berg, Nicholas H. F. Fine, Andreas Friebe, Martin Zacharias, David J. Hodson, Dirk Trauner, Anja Hoffmann-Röder Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone published pages: 4644-4653, ISSN: 2041-6520, DOI: 10.1039/c6sc05044a |
Chemical Science 8/6 | 2019-04-18 |
| 2017 |
Ben J. Jones, Rosario Scopelliti, Alejandra Tomas, Stephen R. Bloom, David J. Hodson, Johannes Broichhagen Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor published pages: 501-505, ISSN: 2191-1363, DOI: 10.1002/open.201700062 |
ChemistryOpen 6/4 | 2019-04-18 |
| 2018 |
Sharan Janjuha, Sumeet Pal Singh, Anastasia Tsakmaki, S Neda Mousavy Gharavy, Priyanka Murawala, Judith Konantz, Sarah Birke, David J Hodson, Guy A Rutter, Gavin A Bewick, Nikolay Ninov Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.32965 |
eLife 7 | 2019-04-18 |
| 2018 |
James A. Frank, Johannes Broichhagen, Dmytro A. Yushchenko, Dirk Trauner, Carsten Schultz, David J. Hodson Optical tools for understanding the complexity of β-cell signalling and insulin release published pages: 721-737, ISSN: 1759-5029, DOI: 10.1038/s41574-018-0105-2 |
Nature Reviews Endocrinology 14/12 | 2019-04-18 |
| 2018 |
Daniela Nasteska, David J Hodson The role of beta cell heterogeneity in islet function and insulin release published pages: R43-R60, ISSN: 0952-5041, DOI: 10.1530/JME-18-0011 |
Journal of Molecular Endocrinology 61/1 | 2019-04-18 |
| 2018 |
Tom Podewin, Julia Ast, Johannes Broichhagen, Nicholas H. F. Fine, Daniela Nasteska, Philipp Leippe, Manuel Gailer, Teresa Buenaventura, Nisha Kanda, Ben J. Jones, Celine M’Kadmi, Jean-Louis Baneres, Jacky Marie, Alejandra Tomas, Dirk Trauner, Anja Hoffmann-Röder, David J. Hodson Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology published pages: 166-179, ISSN: 2374-7943, DOI: 10.1021/acscentsci.7b00237 |
ACS Central Science 4/2 | 2019-04-18 |
| 2017 |
James Allen Frank, Dmytro A. Yushchenko, Nicholas H. F. Fine, Margherita Duca, Mevlut Citir, Johannes Broichhagen, David J. Hodson, Carsten Schultz, Dirk Trauner Optical control of GPR40 signalling in pancreatic β-cells published pages: 7604-7610, ISSN: 2041-6520, DOI: 10.1039/c7sc01475a |
Chem. Sci. 8/11 | 2019-04-18 |
| 2018 |
Richard K.P. Benninger, David J. Hodson New Understanding of β-Cell Heterogeneity and In Situ Islet Function published pages: 537-547, ISSN: 0012-1797, DOI: 10.2337/dbi17-0040 |
Diabetes 67/4 | 2019-04-18 |
| 2018 |
Richard K. P. Benninger, Craig Dorrell, David J. Hodson, Guy A. Rutter The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis published pages: , ISSN: 1534-4827, DOI: 10.1007/s11892-018-1085-2 |
Current Diabetes Reports 18/11 | 2019-04-18 |
| 2018 |
Kate E.R. Hollinshead, Haydn Munford, Katherine L. Eales, Chiara Bardella, Chunjie Li, Cristina Escribano-Gonzalez, Alpesh Thakker, Yannic Nonnenmacher, Katarina Kluckova, Mark Jeeves, Robert Murren, Federica Cuozzo, Dan Ye, Giulio Laurenti, Wei Zhu, Karsten Hiller, David J. Hodson, Wei Hua, Ian P. Tomlinson, Christian Ludwig, Ying Mao, Daniel A. Tennant Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis published pages: 3107-3114, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.02.084 |
Cell Reports 22/12 | 2019-04-18 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "OPTOBETA" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "OPTOBETA" are provided by the European Opendata Portal: CORDIS opendata.