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ULTRACHIRAL SIGNED

Ultrasensitive chiral detection by signal-reversing cavity polarimetry: applications to in-situ proteomics, single-molecule chirality, HPLC analysis, medical diagnostics, and atmospheric studies

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

ULTRACHIRAL project word cloud

Explore the words cloud of the ULTRACHIRAL project. It provides you a very rough idea of what is the project "ULTRACHIRAL" about.

individual cosmetic identification fundamental cavity solution pharmaceutical absolute commercial give revolutionize forest market form proteomics scientific sensitivities limited surfaces grail adapting birefringent property performance single sensing life fluids protein time cells suppressed complexity industries requiring detection molecule medical probe magnitude rapid subfields coupling enhanced constituting signals groundbreaking hplc diagnostic limits sensitivity situ domains orders human measuring standards trees instrument polarimetry weak structure medicine demonstrated improvement reversals microresonators 10s instruments limiting backgrounds holy chemistry ecology price otherwise preventing mixtures chirality membranes despite biology chromatography forests realizing chiral liquid depending tremendous advantages removal monitoring null 1000 ccp signal ultrachiral bodily chemical passes tool biological terpene forth instigate components chiroptical food team billion emissions

Project "ULTRACHIRAL" data sheet

The following table provides information about the project.

Coordinator	IDRYMA TECHNOLOGIAS KAI EREVNAS Organization address address: N PLASTIRA STR 100 city: IRAKLEIO postcode: 70013 website: www.forth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Greece [EL]
Project website	http://ultrachiral.iesl.forth.gr
Total cost	3˙999˙250 €
EC max contribution	3˙999˙250 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IDRYMA TECHNOLOGIAS KAI EREVNAS IDRYMA TECHNOLOGIAS KAI EREVNAS Organization address address: N PLASTIRA STR 100 city: IRAKLEIO postcode: 70013 website: www.forth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (IRAKLEIO)	coordinator	722˙500.00
2	THE UNIVERSITY OF EXETER THE UNIVERSITY OF EXETER Organization address address: THE QUEEN'S DRIVE NORTHCOTE HOUSE city: EXETER postcode: EX4 4QJ website: www.ex.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EXETER)	participant	572˙000.00
3	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 website: www.epfl.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	567˙500.00
4	PANEPISTIMIO KRITIS PANEPISTIMIO KRITIS Organization address address: UNIVERSITY CAMPUS GALLOS city: RETHIMNO postcode: 74100 website: www.uoc.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (RETHIMNO)	participant	544˙750.00
5	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	535˙000.00
6	JOHANNES GUTENBERG-UNIVERSITAT MAINZ JOHANNES GUTENBERG-UNIVERSITAT MAINZ Organization address address: SAARSTRASSE 21 city: MAINZ postcode: 55122 website: www.uni-mainz.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MAINZ)	participant	501˙250.00
7	PHOTEK LIMITED PHOTEK LIMITED Organization address address: CASTLEHAM ROAD 26 city: EAST SUSSEX postcode: TN38 9NS website: www.photek.co.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EAST SUSSEX)	participant	318˙750.00
8	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	237˙500.00

Map

Project objective

Chirality is a fundamental property of life, making chiral sensing and analysis crucial to numerous scientific subfields of biology, chemistry, and medicine, and to the pharmaceutical, chemical, cosmetic, and food industries, constituting a market of 10s of billion €, and growing. Despite the tremendous importance of chiral sensing, its application remains very limited, as chiroptical signals are typically very weak, preventing important biological and medical applications. Recently, the project-coordinating FORTH team has introduced a new form of Chiral-Cavity-based Polarimetry (CCP) for chiral sensing, which has three groundbreaking advantages compared to commercial instruments: (a) The chiroptical signals are enhanced by the number of cavity passes (typically ~1000); (b) otherwise limiting birefringent backgrounds are suppressed; (c) rapid signal reversals give absolute polarimetry measurements, not requiring sample removal for a null-sample measurement. Together, these advantages allow improvement in chiral detection sensitivity by 3-6 orders of magnitude (depending on instrument complexity and price). ULTRACHIRAL aims to revolutionize existing applications of chiral sensing, but also to instigate important new domains which require sensitivities beyond current limits, including: (1) measuring protein structure in-situ, in solution, at surfaces, and within cells and membranes, thus realizing the “holy-grail” of proteomics; (2) coupling to high performance liquid chromatography (HPLC) for chiral identification of the components of complex mixtures, creating new standards for the pharmaceutical and chemical analysis industries; (3) chiral analysis of human bodily fluids as a diagnostic tool in medicine; (4) measurement of single-molecule chirality, by adapting CCP to microresonators, which have already demonstrated single-molecule detection; and (5) real-time chiral monitoring of terpene emissions from individual trees and forests, as a probe of forest ecology.

Deliverables

List of deliverables.
Year 1 progress report	Documents, reports	2019-08-07 12:34:10
Social networks integration	Websites, patent fillings, videos etc.	2019-08-07 12:34:10
Project website	Websites, patent fillings, videos etc.	2019-08-07 12:34:10
Data Management Plan	Open Research Data Pilot	2019-08-07 12:34:10
Kick-off meeting report	Documents, reports	2019-08-07 12:34:10

Take a look to the deliverables list in detail: detailed list of ULTRACHIRAL deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	A. J. Geddes, L. V. Skripnikov, A. Borschevsky, J. C. Berengut, V. V. Flambaum, T. P. Rakitzis Enhanced nuclear-spin-dependent parity-violation effects using the HgH 199 molecule published pages: , ISSN: 2469-9926, DOI: 10.1103/physreva.98.022508	Physical Review A 98/2	2020-03-05
2019	Ershad Mohammadi, Ahad Tavakoli, Parisa Dehkhoda, Yasaman Jahani, Kosmas L. Tsakmakidis, Andreas Tittl, Hatice Altug Accessible Superchiral Near-Fields Driven by Tailored Electric and Magnetic Resonances in All-Dielectric Nanostructures published pages: 1939-1946, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.8b01767	ACS Photonics 6/8	2020-03-05
2019	Michele Gianella, Sioned A. Press, Katherine M. Manfred, Helen C. Norman, Meez Islam, Grant A. D. Ritchie Sensitive detection of HO 2 radicals produced in an atmospheric pressure plasma using Faraday rotation cavity ring-down spectroscopy published pages: 124202, ISSN: 0021-9606, DOI: 10.1063/1.5119191	The Journal of Chemical Physics 151/12	2020-03-05
2019	Sotiris Droulias, Lykourgos Bougas Surface Plasmon Platform for Angle-Resolved Chiral Sensing published pages: 1485-1492, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.9b00137	ACS Photonics 6/6	2020-03-05
2019	Filiz Yesilkoy, Eduardo R. Arvelo, Yasaman Jahani, Mingkai Liu, Andreas Tittl, Volkan Cevher, Yuri Kivshar, Hatice Altug Ultrasensitive hyperspectral imaging and biodetection enabled by dielectric metasurfaces published pages: 390-396, ISSN: 1749-4885, DOI: 10.1038/s41566-019-0394-6	Nature Photonics 13/6	2020-03-05
2019	K. L. Tsakmakidis, O. Reshef, E. Almpanis, G. P. Zouros, E. Mohammadi, D. Saadat, F. Sohrabi, N. Fahimi-Kashani, D. Etezadi, R. W. Boyd, H. Altug Ultrabroadband 3D invisibility with fast-light cloaks published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12813-2	Nature Communications 10/1	2020-03-05
2019	Oleg Tretiak, Peter BlÃ¼mler, Lykourgos Bougas Variable single-axis magnetic-field generator using permanent magnets published pages: 115312, ISSN: 2158-3226, DOI: 10.1063/1.5130896	AIP Advances 9/11	2020-03-05
2019	Sotiris Droulias, Ioannis Katsantonis, Maria Kafesaki, Costas M. Soukoulis, Eleftherios N. Economou Chiral Metamaterials with P T Symmetry and Beyond published pages: , ISSN: 0031-9007, DOI: 10.1103/physrevlett.122.213201	Physical Review Letters 122/21	2020-03-05
2019	Georgios E Katsoprinakis, T Peter Rakitzis Cavity-based chiral polarimetry: parity nonconserving optical rotation in Cs, Dy, and HgH published pages: 213501, ISSN: 0953-4075, DOI: 10.1088/1361-6455/ab410b	Journal of Physics B: Atomic, Molecular and Optical Physics 52/21	2020-03-05
2019	Michael Staudt, Joseph Byron, Karim Piquemal, Jonathan Williams Compartment specific chiral pinene emissions identified in a Maritime pine forest published pages: 1158-1166, ISSN: 0048-9697, DOI: 10.1016/j.scitotenv.2018.11.146	Science of The Total Environment 654	2020-03-05
2019	Sotiris Droulias, Ioannis Katsantonis, Maria Kafesaki, Costas M. Soukoulis, Eleftherios N. Economou Accessible phases via wave impedance engineering with PT -symmetric metamaterials published pages: , ISSN: 2469-9950, DOI: 10.1103/physrevb.100.205133	Physical Review B 100/20	2020-03-05
2018	Andreas Tittl, Aleksandrs Leitis, Mingkai Liu, Filiz Yesilkoy, Duk-Yong Choi, Dragomir N. Neshev, Yuri S. Kivshar, Hatice Altug Imaging-based molecular barcoding with pixelated dielectric metasurfaces published pages: 1105-1109, ISSN: 0036-8075, DOI: 10.1126/science.aas9768	Science 360/6393	2019-08-07
2018	Daniel Rodrigo, Andreas Tittl, Nadine Ait-Bouziad, Aurelian John-Herpin, Odeta Limaj, Christopher Kelly, Daehan Yoo, Nathan J. Wittenberg, Sang-Hyun Oh, Hilal A. Lashuel, Hatice Altug Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04594-x	Nature Communications 9/1	2019-08-07
2018	Dordaneh Etezadi, John B. Warner, Hilal A. Lashuel, Hatice Altug Real-Time In Situ Secondary Structure Analysis of Protein Monolayer with Mid-Infrared Plasmonic Nanoantennas published pages: 1109-1117, ISSN: 2379-3694, DOI: 10.1021/acssensors.8b00115	ACS Sensors 3/6	2019-08-07

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