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GLYCONEOBRAIN TERMINATED

Exploring glycosidic neo-epitopes of degenerative hippocampal granules in aged mice and humans: implications for ageing and dementia

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GLYCONEOBRAIN project word cloud

Explore the words cloud of the GLYCONEOBRAIN project. It provides you a very rough idea of what is the project "GLYCONEOBRAIN" about.

binding    epitope    igm    human    multidisciplinary    schiff    hippocampus    mouse    biomarkers    antibodies    diseases    technologies    neuronal    people    anti    natural    maldi    microdissection    glycomics    model    correlate    goals    strategies    explored    composition    ageing    contains    neurodegenerative    suggesting    positive    therapeutic    data    techniques    neurobiology    expression    molecular    granules    patterns    glycosidic    accordingly    edge    additionally    granular    will    fatal    describe    underlying    astrocytes    disease    reported    age    humans    brain    granule    million    treatment    structures    laser    removal    insights    originate    lafora    acid    adjacent    memory    structure    hippocampal    capture    histological    found    express    potentional    appears    ms    employ    bodies    mice    neo    recognise    hallmark    ultimately    mechanism    neoepitopes    analytical    stain    pathological    impairments    imaging    epitopes    periodic    prevention    dementia    igms    generate    serum    degenerative   

Project "GLYCONEOBRAIN" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF LIVERPOOL    more Organization address address: BROWNLOW HILL 765 FOUNDATION BUILDING city: LIVERPOOL postcode: L69 7ZX website: www.liverpool.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF LIVERPOOL × THE UNIVERSITY OF LIVERPOOL Organization address address: BROWNLOW HILL 765 FOUNDATION BUILDING city: LIVERPOOL postcode: L69 7ZX website: www.liverpool.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a. Close	UK (LIVERPOOL)	coordinator	183˙454.00

Map

 Project objective

Ageing is the main correlate of dementia and several other neurodegenerative diseases which currently affect more than 6 million people in Europe. Molecular understanding of these brain conditions is important for their prevention and treatment. In mice, pathological granular structures positive for periodic acid-Schiff stain have been found in the hippocampus with increasing age. The degenerative process of granule formation appears to originate in astrocytes, but adjacent neuronal structures are affected and, accordingly, associated memory impairments have been described. Recent studies reported that granules express glycosidic neo-epitopes, a hallmark of the degenerative granule formation process. This neo-epitope has additionally been found in Lafora bodies of a mouse model of Lafora disease, a fatal neurodegenerative condition. On the other hand, mice serum contains natural IgM antibodies that recognise the glycosidic neo-epitope, suggesting a potentional removal mechanism. In this project, I aim to describe the structure of the glycosidic neo-epitopes of the hippocampal granules as well as the composition of the degenerative granules and Lafora bodies. To achieve these goals, I will employ a multidisciplinary approach exploiting glycomics and neurobiology, with the application of leading-edge technologies that include histological methods, analytical techniques, MALDI-MS imaging and laser-capture microdissection. Moreover, the binding patterns of the anti-neo-epitope natural IgMs will also be explored. Finally and importantly, the expression of the glycosidic neo-epitope in human brain will be assessed. Overall, the knowledge generated will provide new data on brain degenerative processes underlying age-related memory impairments in humans. Ultimately this project will generate new insights for the use of glycosidic neoepitopes as biomarkers for ageing and neurodegenerative diseases, and for prevention and therapeutic strategies using natural antibodies.

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The information about "GLYCONEOBRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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