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MaRiA SIGNED

Microbiota and Resolvins in Arthritis

Total Cost €

EC-Contrib. €

Partnership

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MaRiA project word cloud

Explore the words cloud of the MaRiA project. It provides you a very rough idea of what is the project "MaRiA" about.

characterise remaining severe options tissue barrier associations function prevotella action dysbiosis resolving disease exacerbation diagnostic carry chronic microbiota local trigger inflammatory gut triggered docosapentaenoic hypothesis chronicity arthritic profiles lipid plasma lm acid gingivalis intestinal treatment dpa copri host impair pronged insights significantly regulating mice inflammation considerable arthritis ra protective exacerbated termed levels pathobionts regulation ing resolvins mechanisms pathobiont mediators porphyromonas rheumatoid family found actions patients socioeconomic markers therapeutic pro immunosuppression underlying detection rvdn altered dysbiotic

Project "MaRiA" data sheet

The following table provides information about the project.

Coordinator	QUEEN MARY UNIVERSITY OF LONDON Organization address address: 327 MILE END ROAD city: LONDON postcode: E1 4NS website: http://www.qmul.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-RI
Starting year	2017
Duration (year-month-day)	from 2017-09-21 to 2020-02-21

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	QUEEN MARY UNIVERSITY OF LONDON QUEEN MARY UNIVERSITY OF LONDON Organization address address: 327 MILE END ROAD city: LONDON postcode: E1 4NS website: http://www.qmul.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	195˙454.00

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Project objective

The proposed work will investigate the regulation of pro-resolving lipid mediators (LM) by pathobionts and dysbiotic microbiota in rheumatoid arthritis (RA).

RA is a chronic inflammatory disease with considerable socioeconomic impact. Most treatment options carry severe side effects including immunosuppression. Recent studies found associations between RA and dysbiosis of the microbiota, with the underlying mechanisms leading to this dysbiosis remaining of interest. In addition, I recently found that in both mice during pathobiont-driven inflammatory arthritis and in plasma from patients with RA the levels of a novel family of host protective LM, termed n-3 docosapentaenoic acid-derived Resolvins (RvDn-3 DPA), were significantly altered.

The novel hypothesis of this action is that pathobionts and pathobiont-induced gut-dysbiosis trigger local inflammatory responses and impair the production of RvDn-3 DPA, resulting in exacerbation and chronicity of local inflammation.

This novel hypothesis will be addressed using a multi-pronged approach to:

1) Characterise the role of Porphyromonas gingivalis and Prevotella copri in regulating RvDn-3 DPA, local inflammation and their effects on intestinal microbiota and gut barrier function.

2) Assess the regulation of inflammatory arthritis and RvDn-3 DPA by RA patients’ microbiota.

3) Establish the protective actions of RvDn-3 DPA in pathobiont-driven inflammatory arthritis.

This will provide insights into mechanisms of pathobiont- and dysbiotic microbiota-triggered arthritic inflammation, the regulation of tissue LM profiles and identify potential novel diagnostic markers for early RA-detection. In addition, this work will establish the therapeutic potential of RvDn-3 DPA in regulating exacerbated inflammation and dysbiosis in inflammatory arthritis, providing novel therapeutic opportunities for RA treatment.

Publications

List of publications.
year	authors and title	journal	last update
2020	E. MuÃ±oz-Atienza, M.B. Flak, J. Sirr, N.A. Paramonov, J. Aduse-Opoku, C. Pitzalis, M.A. Curtis The P. gingivalis Autocitrullinome Is Not a Target for ACPA in Early Rheumatoid Arthritis published pages: 456-462, ISSN: 0022-0345, DOI: 10.1177/0022034519898144	Journal of Dental Research 99/4	2020-04-15
2019	Magdalena B. Flak, Romain A. Colas, EstefanÃa MuÃ±oz-Atienza, Michael A. Curtis, Jesmond Dalli, Costantino Pitzalis Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.125191	JCI Insight 4/13	2020-04-15

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The information about "MARIA" are provided by the European Opendata Portal: CORDIS opendata.