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Debrasa

Deep brain targets for neurostimulation in affective disorders

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Debrasa project word cloud

Explore the words cloud of the Debrasa project. It provides you a very rough idea of what is the project "Debrasa" about.

individual abnormity identification stimulation overarching regions brain relevance characterisation eeg distributed disorder resistant suggested controls recording deep neurobiology functional neurostimulation abnormally performed action microstate density neuronal treatment network pathophysiology undergo causal head individualised individually nodes connectivity healthy hd linear model dbs electrophysiological source mdd signals suggestion patients roi abnormities biomarkers twenty efficacy directed inverse abnormal trd solution resting depression objective made affective granger interconnected

Project "Debrasa" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE DE GENEVE Organization address address: RUE DU GENERAL DUFOUR 24 city: GENEVE postcode: 1211 website: www.unige.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	187˙419 €
EC max contribution	187˙419 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-05-01 to 2019-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE DE GENEVE UNIVERSITE DE GENEVE Organization address address: RUE DU GENERAL DUFOUR 24 city: GENEVE postcode: 1211 website: www.unige.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVE)	coordinator	187˙419.00

Map

Project objective

Objective: The overarching goal of proposed project is to provide necessary knowledge about neurobiology of Major Depression Disorder (MDD), which would lead to higher efficacy in treatment of this affective disorder. The research objectives of the action are 1) identification of electrophysiological biomarkers of functional brain abnormities in treatment resistant depression (TRD) and 2) suggestion of novel targets for neurostimulation in patients with TRD. Methods: Twenty patients with major Depression Disorder (MDD) and 20 healthy controls will undergo a resting-state high-density EEG recording (HD-EEG). Microstate analysis will be performed to identify possible biomarkers of functional brain abnormity in MDD. Source activity will be obtained for regions of interest (ROI) using individual head model and a distributed linear inverse solution. Directed functional connectivity using Granger causal modelling will be applied to the source signals of ROI to identify abnormally interconnected nodes. Relevance: If new biomarkers of functional brain abnormity in MDD are identified, better characterisation of pathophysiology of depression will be made. If abnormal nodes of large-scale brain neuronal network are identified, new and individually specific targets for deep brain stimulation (DBS) will be suggested. These findings will support future implementation of highly individualised DBS treatment of TRD.

Publications

List of publications.
year	authors and title	journal	last update
2020	Alena DamborskÃ¡, EliÅ¡ka HonzÃrkovÃ¡, Richard BarteÄek, Jana HoÅ™ÃnkovÃ¡, Sylvie FedorovÃ¡, Å imon OndruÅ¡, Christoph M. Michel, Maria Rubega Altered directed functional connectivity of the right amygdala in depression: high-density EEG study published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-020-61264-z	Scientific Reports 10/1	2020-03-24
2019	Alena DamborskÃ¡, Camille Piguet, Jean-Michel Aubry, Alexandre G. Dayer, Christoph M. Michel, Cristina Berchio Altered Electroencephalographic Resting-State Large-Scale Brain Network Dynamics in Euthymic Bipolar Disorder Patients published pages: , ISSN: 1664-0640, DOI: 10.3389/fpsyt.2019.00826	Frontiers in Psychiatry 10	2019-11-22
2019	Dominik Drobisz, Alena DamborskÃ¡ Deep brain stimulation targets for treating depression published pages: 266-273, ISSN: 0166-4328, DOI: 10.1016/j.bbr.2018.11.004	Behavioural Brain Research 359	2019-09-25
2019	Alena DamborskÃ¡, Miralena I. Tomescu, EliÅ¡ka HonzÃrkovÃ¡, Richard BarteÄek, Jana HoÅ™ÃnkovÃ¡, Sylvie FedorovÃ¡, Å imon OndruÅ¡, Christoph M. Michel EEG Resting-State Large-Scale Brain Network Dynamics Are Related to Depressive Symptoms published pages: , ISSN: 1664-0640, DOI: 10.3389/fpsyt.2019.00548	Frontiers in Psychiatry 10	2019-09-25

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The information about "DEBRASA" are provided by the European Opendata Portal: CORDIS opendata.