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EvoMachine-Phage SIGNED

Using the Evolution Machine to determine the mechanism of a novel Phage-Induced High-Cell-Density (PIHCD) phenotype

Total Cost €

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EC-Contrib. €

0

Partnership

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Project "EvoMachine-Phage" data sheet

The following table provides information about the project.

Coordinator
ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS 

Organization address
address: RUE VAUQUELIN 10
city: PARIS
postcode: 75231
website: www.espci-paristech.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.stevenquistad.com/
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS FR (PARIS) coordinator 173˙076.00

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 Project objective

Bacteriophages (phages) drive the evolution of bacteria by antagonistic coevolution and by promoting transfer of genetic material between bacteria. Phages are intimately involved in a range of biological processes from carbon cycling to the maintenance of human health. Despite their global importance the coevolution between natural phage communities and their bacterial hosts remains poorly understood. This project seeks to understand the mechanism behind a Phage-Induced High-Cell-Density (PIHCD) phenotype using a droplet-based microfluidic device termed the Evolution Machine, developed at the proposed institution (ESPCI Paris). Work Package 1 (WP1) will use the Evolution Machine to determine and characterize the phage(s) responsible for the PIHCD phenotype through coinfection with their Pseudomonas fluorescens host. WP2 will determine the mechanistic basis of the PIHCD phenotype using transcriptomics and genetic manipulation. Finally, in WP3 the long term coevolution between phage(s) and host will be investigated using the droplet-level selection capabilities of the Evolution Machine combined with comparative genomic analysis. Through this fellowship ESPCI Paris will gain from my expertise in molecular biology and bioinformatics while I will develop new skills in microbiology (phage-host coevolution and genetic manipulation) and microfluidic technology (Evolution Machine).

 Publications

year authors and title journal last update
List of publications.
2019 Steven D. Quistad, Guilhem Doulcier, Paul B. Rainey
Experimental manipulation of selfish genetic elements links genes to microbial community function
published pages: , ISSN: , DOI: 10.1101/608752
BioRxiv 2019-05-15

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