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FUNCOPLAN SIGNED

Functions of plasticity in adult-born neurons

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

FUNCOPLAN project word cloud

Explore the words cloud of the FUNCOPLAN project. It provides you a very rough idea of what is the project "FUNCOPLAN" about.

population cells precisely cancel olfactory newly na vital examine functional ve mature combination altered mimic fundamental additional period ground exactly life neurons works funcoplan produces influx unknown transient iuml neuronal networks wholly manipulating contribution brain continual circuitry influence first discover immature shaping capacity discoveries integrating questions adult cellular vivo resident break mammalian innovative renowned network born achievable freshly demonstrating groundbreaking plasticity bulb function techniques modulation undergo join sensory alone heightened dependent circuits play plastic neurogenesis completely continually shapes dopaminergic

Project "FUNCOPLAN" data sheet

The following table provides information about the project.

Coordinator	KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	2˙000˙000 €
EC max contribution	2˙000˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-COG
Funding Scheme	ERC-COG
Starting year	2017
Duration (year-month-day)	from 2017-06-01 to 2022-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	2˙000˙000.00

Map

Project objective

The major objective of FUNCOPLAN is to examine groundbreaking questions on the functional role of newly-generated neurons in the adult brain. Using a combination of innovative approaches, our aim is to discover how plasticity in adult-born cells shapes information processing in neuronal circuits.

Adult neurogenesis produces new neurons in particular areas of the mammalian brain throughout life. Because they undergo a transient period of heightened plasticity, these freshly-generated cells are believed to bring unique properties to the circuits they join – a continual influx of new, immature cells is believed to provide a level of plasticity not achievable by the mature, resident network alone. But what exactly is the function of the additional plasticity provided by adult-born neurons? How does it influence information processing in neuronal networks?

These questions are vital for our fundamental understanding of how the brain works. We will address them by studying a unique population of cells that is continually generated throughout life: dopaminergic neurons in the olfactory bulb. These cells play a key role in the modulation of early sensory responses and are renowned for their plastic capacity. However, the role of this plasticity in shaping sensory processing remains completely unknown. FUNCOPLAN’s first objectives, therefore, are to discover novel experience-dependent plastic changes in the cellular features and sensory response properties of adult-born neurons. We will then go much further than this, however, by integrating our discoveries with state-of-the-art techniques for precisely manipulating activity in these cells in vivo. This wholly innovative approach will allow us to mimic the effects of plasticity in naïve circuits, or cancel the effects of plasticity in experience-altered networks. In this way, we will break new ground, demonstrating a unique contribution of plasticity in adult-born cells to the fundamental function of neuronal circuitry.

Deliverables

List of deliverables.
Data Management Plan	Open Research Data Pilot	2019-07-18 23:13:48

Take a look to the deliverables list in detail: detailed list of FUNCOPLAN deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Elisa Galliano, Eleonora Franzoni, Marine Breton, Annisa N Chand, Darren J Byrne, Venkatesh N Murthy, Matthew S Grubb Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.32373	eLife 7	2019-07-18

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The information about "FUNCOPLAN" are provided by the European Opendata Portal: CORDIS opendata.